Development Level

Tdark 87 | 7,003
Tchem 77 | 1,890
Tbio 71 | 10,625
Tclin 11 | 602

IMPC Term

preweaning lethality, incomple... 6 | 260
preweaning lethality, complete... 5 | 633
decreased body length 3 | 108
decreased lean body mass 3 | 195
increased circulating sodium l... 3 | 71
increased mean corpuscular hem... 3 | 93
abnormal behavior 2 | 226
abnormal bone mineralization 2 | 55
abnormal bone structure 2 | 131
abnormal embryo size 2 | 112
decreased B cell number 2 | 30
decreased T cell number 2 | 31
decreased body weight 2 | 174
decreased bone mineral content 2 | 157
decreased bone mineral density 2 | 126
decreased circulating choleste... 2 | 85
decreased circulating glucose ... 2 | 121
decreased prepulse inhibition 2 | 52
decreased total body fat amoun... 2 | 186
embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
enlarged heart 2 | 111
increased CD8-positive, alpha-... 2 | 11
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular vol... 2 | 91
short tibia 2 | 82
thrombocytopenia 2 | 46
abnormal behavioral response t... 1 | 52
abnormal body wall morphology 1 | 7
abnormal coat/ hair morphology 1 | 18
abnormal esophagus morphology 1 | 4
abnormal facial morphology 1 | 9
abnormal heart morphology 1 | 51
abnormal joint morphology 1 | 14
abnormal limb bud morphology 1 | 15
abnormal limb morphology 1 | 7
abnormal neural tube closure 1 | 37
abnormal pancreas morphology 1 | 6
abnormal retina morphology 1 | 100
abnormal skin coloration 1 | 18
abnormal snout morphology 1 | 18
abnormal tail morphology 1 | 17
abnormal testis morphology 1 | 30
abnormal thyroid gland morphol... 1 | 3
abnormal tibia morphology 1 | 14
abnormal trachea morphology 1 | 3
abnormal vibrissa morphology 1 | 17
absent lymph nodes 1 | 3
anophthalmia 1 | 20
athymia 1 | 1
cleft palate 1 | 6
convulsive seizures 1 | 11
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased NK T cell number 1 | 28
decreased alpha-beta T cell nu... 1 | 12
decreased circulating HDL chol... 1 | 77
decreased circulating free fat... 1 | 39
decreased circulating fructosa... 1 | 31
decreased circulating triglyce... 1 | 83
decreased effector memory CD4-... 1 | 6
decreased effector memory CD8-... 1 | 24
decreased effector memory T-he... 1 | 2
decreased gamma-delta T cell n... 1 | 18
decreased granulocyte number 1 | 8
decreased heart weight 1 | 44
decreased macrophage cell numb... 1 | 4
embryonic growth retardation 1 | 28
enlarged spleen 1 | 26
female infertility 1 | 34
hemorrhage 1 | 12
increased B cell number 1 | 23
increased CD8-positive, naive ... 1 | 3
increased KLRG1-positive NK ce... 1 | 9
increased Ly6C high monocyte n... 1 | 12
increased Ly6C low monocyte nu... 1 | 8
increased NK cell number 1 | 19
increased T cell number 1 | 15
increased blood urea nitrogen ... 1 | 44
increased circulating alkaline... 1 | 119
increased circulating amylase ... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 43
increased circulating iron lev... 1 | 25
increased eosinophil cell numb... 1 | 9
increased erythrocyte cell num... 1 | 26
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased mature B cell number 1 | 12
increased or absent threshold ... 1 | 128
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
male infertility 1 | 62
oligodactyly 1 | 14
premature death 1 | 5
small testis 1 | 37
straub tail 1 | 26
tremors 1 | 34

Disease

psoriasis 92 | 6,685
osteosarcoma 70 | 7,933
ovarian cancer 70 | 8,484
lung adenocarcinoma 56 | 2,713
lung cancer 53 | 4,466
pancreatic cancer 53 | 2,300
intraductal papillary-mucinous neoplasm (IPMN) 50 | 3,289
Cancer 49 | 2,346
ulcerative colitis 46 | 2,087
non-small cell lung cancer 45 | 2,798
lung carcinoma 42 | 2,844
cystic fibrosis 41 | 1,665
intraductal papillary-mucinous adenoma (IPMA) 40 | 2,956
interstitial cystitis 39 | 2,299
invasive ductal carcinoma 39 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,988
glioblastoma 37 | 5,572
medulloblastoma, large-cell 37 | 6,234
tuberculosis 34 | 1,557
malignant mesothelioma 33 | 3,162
cutaneous lupus erythematosus 32 | 1,056
atypical teratoid / rhabdoid tumor 29 | 4,369
Atopic dermatitis 27 | 944
Breast cancer 27 | 3,094
diabetes mellitus 27 | 1,663
pilocytic astrocytoma 27 | 3,086
primary pancreatic ductal adenocarcinoma 27 | 1,271
pancreatic ductal adenocarcinoma liver metastasis 26 | 1,795
periodontitis 22 | 269
esophageal adenocarcinoma 21 | 737
subependymal giant cell astrocytoma 21 | 2,287
posterior fossa group A ependymoma 20 | 1,511
Vascular disease 19 | 281
colon cancer 19 | 1,475
nasopharyngeal carcinoma 19 | 1,056
pediatric high grade glioma 19 | 2,712
Carcinoma 18 | 2,147
Rheumatoid Arthritis 18 | 1,160
adult high grade glioma 18 | 2,148
breast carcinoma 18 | 1,614
oligodendroglioma 18 | 2,849
gastric carcinoma 17 | 832
pituitary cancer 17 | 1,972
Kidney disease 16 | 396
adrenocortical carcinoma 16 | 1,427
Cerebrovascular disease 15 | 231
Hypertension 15 | 287
ductal carcinoma in situ 15 | 1,745
head and neck cancer and chronic obstructive pulmonary disease 15 | 237
mucosa-associated lymphoid tissue lymphoma 15 | 480
primary Sjogren syndrome 15 | 789
sonic hedgehog group medulloblastoma 15 | 1,482
Pancreatitis 14 | 97
Prostatic Neoplasms 14 | 471
non-small cell lung carcinoma 14 | 413
Alzheimer's disease 13 | 644
Atherosclerosis 13 | 275
Duchenne muscular dystrophy 13 | 602
active Crohn's disease 13 | 918
ependymoma 13 | 2,514
Arthritis 12 | 248
acute quadriplegic myopathy 12 | 1,157
astrocytic glioma 12 | 2,241
astrocytoma 12 | 1,493
group 3 medulloblastoma 12 | 2,254
primitive neuroectodermal tumor 12 | 3,031
Coronary artery disease 11 | 240
Heart disease 11 | 279
Multiple myeloma 11 | 1,327
Thrombophilia 11 | 36
group 4 medulloblastoma 11 | 1,875
inflammatory breast cancer 11 | 404
juvenile dermatomyositis 11 | 1,189
Hypertensive disease 10 | 193
IGA Glomerulonephritis 10 | 454
Obesity 10 | 616
chronic lymphosyte leukemia 10 | 232
fibroadenoma 10 | 557
nephrosclerosis 10 | 329
spina bifida 10 | 1,064
Lung disease 9 | 132
Neoplasm Invasiveness 9 | 127
Periodontal disease 9 | 37
Venous Thrombosis 9 | 21
dermatomyositis 9 | 933
medulloblastoma 9 | 1,524
Complement deficiency 8 | 15
Endometriosis 8 | 535
Lupus erythematosus 8 | 80
Multiple Sclerosis 8 | 498
Myocardial Infarction 8 | 126
Prostate cancer 8 | 172
Thromboembolism 8 | 12
limb girdle muscular dystrophy 2A 8 | 156
non-inflammatory breast cancer 8 | 208
Down syndrome 7 | 548
Pick disease 7 | 1,893
Spontaneous abortion 7 | 108
aldosterone-producing adenoma 7 | 664
pancreatic carcinoma 7 | 567

Tissue

Digestive Tract 224 | 18,473
Female tissues 224 | 18,647
Skin and soft tissues 222 | 18,115
Urinary Tract 222 | 18,444
Blood and immune system 220 | 17,995
Endocrine System 220 | 18,512
Liver and Pancreas 220 | 18,136
Nervous System 219 | 18,561
Cardiovascular System 218 | 17,958
Respiratory system 218 | 17,484
Male tissues 216 | 17,969

Target Family

Enzyme 157 | 4,146
Non-IDG 89 | 11,971

GO Function

serine-type endopeptidase acti... 246 | 246
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Immunoglobulin kappa variable 3-11 IGKV3-11 Tdark Non-IDG 0.00000 0
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Transmembrane protease serine 6 TMPRSS6 Tchem Enzyme -1.99222 118.1 102
Coagulation factor XI F11 Tchem Enzyme -2.65863 487.3 216
Plasma kallikrein KLKB1 Tclin Enzyme -2.88472 708.0 231
Tolloid-like protein 1 TLL1 Tbio Non-IDG -1.40066 23.4 60
Ovochymase-2 OVCH2 Tdark Enzyme 0.00000 0
Transmembrane protease serine 7 TMPRSS7 Tdark Enzyme 0.24 0.97 63
Serine protease 48 PRSS48 Tdark Enzyme 0.00000 63
Serine protease 45 PRSS45 Tdark Enzyme 0.48 0.25 14