Development Level

Tdark 87 | 6,593
Tbio 82 | 11,651
Tchem 66 | 1,388
Tclin 11 | 612

IMPC Phenotype

preweaning lethality, incomple... 9 | 499
preweaning lethality, complete... 7 | 979
abnormal embryo size 4 | 220
decreased bone mineral content 4 | 151
abnormal behavior 3 | 298
decreased circulating HDL chol... 3 | 68
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased lean body mass 3 | 135
embryonic growth retardation 3 | 106
embryonic lethality prior to t... 3 | 278
hypoactivity 3 | 132
increased circulating sodium l... 3 | 71
increased mean corpuscular hem... 3 | 96
short tibia 3 | 97
abnormal bone structure 2 | 187
abnormal heart morphology 2 | 162
abnormal limb bud morphology 2 | 17
abnormal seminal vesicle morph... 2 | 114
abnormal tail morphology 2 | 25
decreased T cell number 2 | 15
decreased body weight 2 | 161
decreased bone mineral density 2 | 126
decreased circulating triglyce... 2 | 79
decreased mean corpuscular vol... 2 | 79
decreased prepulse inhibition 2 | 82
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
enlarged heart 2 | 210
increased blood urea nitrogen ... 2 | 48
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
increased circulating iron lev... 2 | 30
increased hemoglobin content 2 | 45
increased leukocyte cell numbe... 2 | 47
increased startle reflex 2 | 112
male infertility 2 | 123
small superior vagus ganglion 2 | 74
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal body wall morphology 1 | 9
abnormal bone mineralization 1 | 38
abnormal eye morphology 1 | 68
abnormal facial morphology 1 | 17
abnormal joint morphology 1 | 23
abnormal limb morphology 1 | 13
abnormal liver size 1 | 5
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal skin coloration 1 | 25
abnormal skin morphology 1 | 50
abnormal snout morphology 1 | 23
abnormal testis morphology 1 | 43
abnormal tibia morphology 1 | 14
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
cleft palate 1 | 8
convulsive seizures 1 | 13
decreased CD8-positive, alpha-... 1 | 8
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased heart rate 1 | 18
decreased mean platelet volume 1 | 25
decreased red blood cell distr... 1 | 41
decreased threshold for audito... 1 | 26
decreased total body fat amoun... 1 | 207
hemorrhage 1 | 23
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased T cell number 1 | 6
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased heart rate variabili... 1 | 7
increased hematocrit 1 | 46
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
premature death 1 | 5
prenatal lethality prior to he... 1 | 87
prolonged ST segment 1 | 36
small testis 1 | 58
tremors 1 | 39

Disease

Carcinoma 109 | 11,493
psoriasis 92 | 6,694
ovarian cancer 69 | 8,520
osteosarcoma 68 | 7,950
lung adenocarcinoma 55 | 2,716
Cancer 53 | 2,499
lung cancer 52 | 4,740
pancreatic cancer 51 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 48 | 3,291
non-small cell lung cancer 47 | 2,890
cystic fibrosis 42 | 1,696
lung carcinoma 40 | 2,843
ulcerative colitis 40 | 1,819
glioblastoma 39 | 5,792
interstitial cystitis 39 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 38 | 2,955
invasive ductal carcinoma 38 | 2,951
Breast cancer 37 | 3,578
Autosomal recessive predisposition 36 | 1,442
intraductal papillary-mucinous carcinoma (IPMC) 36 | 2,989
medulloblastoma, large-cell 35 | 6,241
malignant mesothelioma 34 | 3,232
cutaneous lupus erythematosus 32 | 1,057
diabetes mellitus 31 | 1,728
tuberculosis 31 | 2,010
adult high grade glioma 29 | 3,801
ependymoma 29 | 4,679
pancreatic ductal adenocarcinoma liver metastasis 28 | 1,962
Astrocytoma, Pilocytic 27 | 3,081
atypical teratoid / rhabdoid tumor 27 | 5,112
Atopic dermatitis 26 | 952
periodontitis 26 | 293
group 3 medulloblastoma 24 | 4,104
primary pancreatic ductal adenocarcinoma 23 | 1,109
Hypertension 22 | 396
subependymal giant cell astrocytoma 21 | 2,287
esophageal adenocarcinoma 20 | 737
colon cancer 19 | 1,478
nasopharyngeal carcinoma 19 | 1,058
Kidney cancer 18 | 2,613
breast carcinoma 18 | 1,638
Kidney disease 17 | 430
Liver Cirrhosis, Experimental 17 | 769
Vascular disease 17 | 319
gastric carcinoma 17 | 807
oligodendroglioma 17 | 2,850
adrenocortical carcinoma 16 | 1,428
pituitary cancer 16 | 1,972
Arthritis 15 | 290
Pancreatitis 15 | 123
Rheumatoid arthritis 15 | 1,191
Schizophrenia 15 | 1,160
head and neck cancer and chronic obstructive pulmonary disease 15 | 239
primary Sjogren syndrome 15 | 735
Cerebrovascular disease 14 | 238
Prostatic Neoplasms 14 | 495
astrocytic glioma 14 | 2,597
ductal carcinoma in situ 14 | 1,745
Alzheimer's disease 13 | 658
Atherosclerosis 13 | 291
Duchenne muscular dystrophy 13 | 601
active Crohn's disease 13 | 922
mucosa-associated lymphoid tissue lymphoma 13 | 484
Heart disease 12 | 306
acute quadriplegic myopathy 12 | 1,158
non-small cell lung carcinoma 12 | 317
Bipolar Disorder 11 | 666
Coronary artery disease 11 | 268
Hypertensive disease 11 | 292
Multiple myeloma 11 | 1,332
group 4 medulloblastoma 11 | 1,855
juvenile dermatomyositis 11 | 1,187
Multiple Sclerosis 10 | 540
Obesity 10 | 678
chronic lymphosyte leukemia 10 | 204
fibroadenoma 10 | 559
primitive neuroectodermal tumor 10 | 3,035
spina bifida 10 | 1,074
Neoplasm Invasiveness 9 | 161
Systemic lupus erythematosus 9 | 194
Thrombophilia 9 | 38
active ulcerative colitis 9 | 764
dermatomyositis 9 | 966
limb girdle muscular dystrophy 2A 9 | 213
nephrosclerosis 9 | 333
Breast Neoplasms 8 | 445
Diarrhea 8 | 253
Endometriosis 8 | 540
Liver disease 8 | 237
Lung disease 8 | 142
Melanoma 8 | 711
Myocardial Infarction 8 | 151
Osteoporosis 8 | 363
Periodontal disease 8 | 40
Pulmonary embolism 8 | 55
astrocytoma 8 | 1,146
Prostate cancer 7 | 175
Stomach Neoplasms 7 | 300
aldosterone-producing adenoma 7 | 665
pediatric high grade glioma 7 | 1,064

Tissue

Endocrine System 173 | 18,159
Female tissues 170 | 17,400
Skin and soft tissues 170 | 17,230
Digestive Tract 169 | 17,369
Blood and immune system 161 | 16,909
Liver and Pancreas 160 | 16,750
Male tissues 160 | 17,142
Urinary Tract 159 | 16,678
Respiratory system 151 | 16,393
Nervous System 150 | 16,725
Cardiovascular System 119 | 15,192

Target Family

Enzyme 153 | 4,145
Non-IDG 93 | 12,091

GO Function

serine-type endopeptidase acti... 246 | 246
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Kallikrein-9 KLK9 Tbio Enzyme -0.89030 8.64 143
Kallikrein-12 KLK12 Tbio Enzyme -0.99694 11.0 111
Serine protease 55 PRSS55 Tdark Enzyme -0.51631 3.86 70
Proprotein convertase subtilisin/kexin type 6 PCSK6 Tchem Enzyme -2.33983 216.4 239
Tripeptidyl-peptidase 2 TPP2 Tbio Enzyme -1.97332 108.2 72
Neurotrypsin PRSS12 Tbio Non-IDG -1.46986 30.6 77
Probable inactive serine protease 37 PRSS37 Tdark Enzyme -0.32034 2.85 18
Chymotrypsin-like protease CTRL-1 CTRL Tchem Enzyme -3.14577 1283.5 150
Tolloid-like protein 2 TLL2 Tbio Non-IDG -1.00652 6.10 35
Testisin PRSS21 Tbio Enzyme -2.09237 118.4 46