Development Level

Tbio 305 | 11,445
Tdark 39 | 6,588
Tchem 22 | 1,598
Tclin 8 | 613

IMPC Phenotype

preweaning lethality, complete... 27 | 979
abnormal embryo size 10 | 220
preweaning lethality, incomple... 10 | 499
embryonic lethality prior to t... 9 | 278
decreased total body fat amoun... 7 | 207
embryonic growth retardation 6 | 106
enlarged heart 6 | 210
increased bone mineral content 6 | 108
decreased circulating triglyce... 5 | 79
decreased vertical activity 5 | 208
hypoactivity 5 | 132
abnormal heart morphology 4 | 162
abnormal seminal vesicle morph... 4 | 114
decreased circulating insulin ... 4 | 76
decreased lymphocyte cell numb... 4 | 83
decreased prepulse inhibition 4 | 82
embryonic lethality prior to o... 4 | 239
increased circulating HDL chol... 4 | 80
increased lean body mass 4 | 172
increased or absent threshold ... 4 | 101
increased startle reflex 4 | 112
small superior vagus ganglion 4 | 74
abnormal behavior 3 | 298
abnormal craniofacial morpholo... 3 | 33
abnormal embryo turning 3 | 31
abnormal forebrain development 3 | 20
abnormal gait 3 | 69
abnormal hindbrain development 3 | 16
abnormal kidney morphology 3 | 65
abnormal neural tube closure 3 | 46
decreased blood urea nitrogen ... 3 | 51
decreased body length 3 | 101
decreased grip strength 3 | 116
decreased hemoglobin content 3 | 68
increased circulating alkaline... 3 | 122
increased monocyte cell number 3 | 63
thrombocytopenia 3 | 56
abnormal bone structure 2 | 187
abnormal midbrain development 2 | 20
abnormal pharyngeal arch morph... 2 | 8
abnormal retina morphology 2 | 71
abnormal sleep behavior 2 | 70
abnormal snout morphology 2 | 23
decreased IgG1 level 2 | 8
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 46
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased circulating serum al... 2 | 82
decreased lean body mass 2 | 135
female infertility 2 | 60
hydrometra 2 | 53
increased circulating choleste... 2 | 66
increased circulating glucose ... 2 | 24
increased fasted circulating g... 2 | 76
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased neutrophil cell numb... 2 | 46
increased total body fat amoun... 2 | 134
male infertility 2 | 123
prolonged QRS complex duration 2 | 8
syndactyly 2 | 23
abnormal coat- hair morphology 1 | 19
abnormal heart left ventricle ... 1 | 16
abnormal heart looping 1 | 5
abnormal locomotor activation 1 | 16
abnormal neural tube morpholog... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
cataract 1 | 92
decreased T cell number 1 | 15
decreased circulating bilirubi... 1 | 19
decreased circulating phosphat... 1 | 27
decreased erythrocyte cell num... 1 | 62
decreased red blood cell distr... 1 | 41
dilated heart left ventricle 1 | 11
enlarged lymph nodes 1 | 37
enlarged urinary bladder 1 | 8
hemorrhage 1 | 23
increased anti-nuclear antigen... 1 | 19
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating creatini... 1 | 38
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased lactate dehydrogenas... 1 | 3
increased leukocyte cell numbe... 1 | 47
increased vertical activity 1 | 24
long tibia 1 | 25
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
small spleen 1 | 19
thrombocytosis 1 | 27
tremors 1 | 39
trunk curl 1 | 16
vertebral fusion 1 | 23

Disease

Carcinoma 214 | 11,493
osteosarcoma 157 | 7,950
ovarian cancer 149 | 8,520
psoriasis 137 | 6,694
medulloblastoma, large-cell 123 | 6,241
glioblastoma 101 | 5,792
atypical teratoid / rhabdoid tumor 95 | 5,112
Cancer 94 | 2,499
lung cancer 93 | 4,740
Breast cancer 84 | 3,578
malignant mesothelioma 83 | 3,232
group 3 medulloblastoma 74 | 4,104
adult high grade glioma 69 | 3,801
invasive ductal carcinoma 66 | 2,951
ependymoma 64 | 4,679
primitive neuroectodermal tumor 59 | 3,035
interstitial cystitis 56 | 2,312
non-small cell lung cancer 53 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 50 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 49 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 47 | 2,989
Astrocytoma, Pilocytic 45 | 3,081
Kidney cancer 45 | 2,613
breast carcinoma 45 | 1,638
lung adenocarcinoma 45 | 2,716
oligodendroglioma 45 | 2,850
cystic fibrosis 43 | 1,696
group 4 medulloblastoma 43 | 1,855
ductal carcinoma in situ 42 | 1,745
ulcerative colitis 39 | 1,819
pancreatic cancer 38 | 2,398
astrocytic glioma 37 | 2,597
pituitary cancer 37 | 1,972
Intellectual disability 34 | 1,016
lung carcinoma 33 | 2,843
subependymal giant cell astrocytoma 33 | 2,287
Autosomal recessive predisposition 32 | 1,442
colon cancer 29 | 1,478
tuberculosis 29 | 2,010
Bipolar Disorder 28 | 666
Pick disease 27 | 1,894
Rheumatoid arthritis 27 | 1,191
diabetes mellitus 27 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,962
Schizophrenia 26 | 1,160
spina bifida 26 | 1,074
Craniofacial Abnormalities 25 | 151
adrenocortical carcinoma 25 | 1,428
primary pancreatic ductal adenocarcinoma 25 | 1,109
Breast Neoplasms 24 | 445
Cleft Palate 24 | 271
Obesity 24 | 678
astrocytoma 24 | 1,146
Dull intelligence 23 | 645
Low intelligence 23 | 645
Mammary Neoplasms 23 | 425
Mental Retardation 23 | 645
Mental deficiency 23 | 645
Poor school performance 23 | 645
dermatomyositis 23 | 966
Short stature 21 | 531
cutaneous lupus erythematosus 21 | 1,057
gastric carcinoma 21 | 807
pediatric high grade glioma 21 | 1,064
Multiple myeloma 20 | 1,332
juvenile dermatomyositis 20 | 1,187
Sensorineural Hearing Loss (disorder) 19 | 284
Small head 19 | 374
Cognitive delay 18 | 608
Global developmental delay 18 | 608
Mental and motor retardation 18 | 608
Cataract 17 | 297
Epilepsy 17 | 792
acute quadriplegic myopathy 17 | 1,158
medulloblastoma 17 | 720
primary Sjogren syndrome 17 | 735
Atopic dermatitis 16 | 952
Crohn's disease 16 | 321
Cryptorchidism 16 | 296
Muscle hypotonia 16 | 571
Ventricular Septal Defects 16 | 119
Seizures 15 | 596
aldosterone-producing adenoma 15 | 665
Cleft Lip 14 | 141
Congenital heart disease 14 | 93
Melanoma 14 | 711
Multiple Sclerosis 14 | 540
Orbital separation excessive 14 | 244
Prostatic Neoplasms 14 | 495
Uranostaphyloschisis 14 | 167
acute myeloid leukemia 14 | 783
non primary Sjogren syndrome sicca 14 | 891
Broad flat nasal bridge 13 | 236
Endometriosis 13 | 540
Liver cancer 13 | 604
Mental Depression 13 | 333
Nasal bridge wide 13 | 236
fibroadenoma 13 | 559
posterior fossa group A ependymoma 13 | 468
urothelial carcinoma 13 | 318

Tissue

Endocrine System 352 | 18,159
Digestive Tract 324 | 17,369
Skin and soft tissues 319 | 17,230
Male tissues 317 | 17,142
Female tissues 314 | 17,400
Blood and immune system 308 | 16,909
Urinary Tract 300 | 16,678
Nervous System 290 | 16,725
Liver and Pancreas 285 | 16,750
Respiratory system 282 | 16,393
Cardiovascular System 248 | 15,192

Target Family

Transcription Factor 296 | 1,400
Non-IDG 40 | 12,091
Nuclear Receptor 23 | 48
Epigenetic 8 | 242
TF/Epigenetic 4 | 38
Enzyme 2 | 4,145
Kinase 1 | 634

GO Function

sequence-specific DNA binding 374 | 374
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Metastasis-associated protein MTA3 MTA3 Tbio Transcription Factor -1.36174 24.5 204
SAFB-like transcription modulator SLTM Tdark Non-IDG -0.51977 2.83 111
Metastasis-associated protein MTA2 MTA2 Tbio Transcription Factor -1.59201 32.3 283
LIM/homeobox protein Lhx8 LHX8 Tbio Transcription Factor -1.58436 40.6 163
Forkhead box protein C2 FOXC2 Tbio Transcription Factor -2.23435 187.0 419
Neural retina-specific leucine zipper protein NRL Tbio Transcription Factor -2.46080 279.4 74
Krueppel-like factor 2 KLF2 Tbio Transcription Factor -2.30630 216.2 308
POU domain, class 2, transcription factor 3 POU2F3 Tbio Transcription Factor -2.50813 322.4 96
Eomesodermin homolog EOMES Tbio Transcription Factor -2.37902 230.4 333
T-box transcription factor TBX21 TBX21 Tbio Transcription Factor -2.95359 868.5 480