Development Level

Tbio 32 | 11,651
Tchem 13 | 1,388
Tclin 9 | 612
Tdark 1 | 6,593

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 5 | 499
decreased body weight 3 | 161
increased circulating chloride... 3 | 41
abnormal behavior 2 | 298
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
increased circulating sodium l... 2 | 71
abnormal behavioral response t... 1 | 66
abnormal eating behavior 1 | 1
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal facial morphology 1 | 17
abnormal femur morphology 1 | 14
abnormal forced expiratory flo... 1 | 1
abnormal gait 1 | 69
abnormal head shape 1 | 10
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal outer ear morphology 1 | 3
abnormal testis morphology 1 | 43
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
cyanosis 1 | 7
decreased body temperature 1 | 2
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating magnesiu... 1 | 13
decreased circulating phosphat... 1 | 27
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased tidal volume 1 | 1
edema 1 | 59
hemorrhage 1 | 23
hyperactivity 1 | 148
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 108
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased granulocyte number 1 | 1
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
small testis 1 | 58
thrombocytopenia 1 | 56
tremors 1 | 39

Disease

Carcinoma 47 | 11,493
psoriasis 30 | 6,694
osteosarcoma 28 | 7,950
ovarian cancer 27 | 8,520
glioblastoma 25 | 5,792
medulloblastoma, large-cell 23 | 6,241
atypical teratoid / rhabdoid tumor 22 | 5,112
Kidney cancer 20 | 2,613
ependymoma 19 | 4,679
group 3 medulloblastoma 19 | 4,104
Astrocytoma, Pilocytic 18 | 3,081
Cancer 18 | 2,499
adult high grade glioma 18 | 3,801
lung cancer 17 | 4,740
lung carcinoma 16 | 2,843
malignant mesothelioma 16 | 3,232
subependymal giant cell astrocytoma 15 | 2,287
Autosomal recessive predisposition 13 | 1,442
Breast cancer 13 | 3,578
diabetes mellitus 12 | 1,728
oligodendroglioma 12 | 2,850
primitive neuroectodermal tumor 12 | 3,035
colon cancer 11 | 1,478
Autistic Disorder 10 | 364
Intellectual disability 10 | 1,016
Schizophrenia 10 | 1,160
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
invasive ductal carcinoma 10 | 2,951
lung adenocarcinoma 10 | 2,716
non-small cell lung cancer 10 | 2,890
Breast Neoplasms 9 | 445
Mammary Neoplasms 9 | 425
astrocytic glioma 9 | 2,597
breast carcinoma 9 | 1,638
juvenile dermatomyositis 9 | 1,187
pituitary cancer 9 | 1,972
ulcerative colitis 9 | 1,819
group 4 medulloblastoma 8 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
pancreatic cancer 8 | 2,398
tuberculosis 8 | 2,010
Depressive disorder 7 | 409
Epilepsy 7 | 792
Neurodegenerative disease 7 | 414
Prostatic Neoplasms 7 | 495
cutaneous lupus erythematosus 7 | 1,057
ductal carcinoma in situ 7 | 1,745
interstitial cystitis 7 | 2,312
Atrial Fibrillation 6 | 124
Cerebrovascular disease 6 | 238
Melanoma 6 | 711
Mental Depression 6 | 333
astrocytoma 6 | 1,146
cystic fibrosis 6 | 1,696
Alzheimer's disease 5 | 658
Amyotrophic lateral sclerosis 5 | 451
Autism spectrum disorder 5 | 101
Bipolar Disorder 5 | 666
Cardiomegaly 5 | 116
Cardiomyopathy 5 | 116
Cell Transformation, Neoplastic 5 | 97
Hypertension 5 | 396
Liver cancer 5 | 604
Neoplastic Cell Transformation 5 | 89
Obesity 5 | 678
Short stature 5 | 531
Stomach Neoplasms 5 | 300
Toxic encephalopathy 5 | 141
acute quadriplegic myopathy 5 | 1,158
adrenocortical carcinoma 5 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
hepatocellular carcinoma 5 | 547
pancreatic carcinoma 5 | 562
posterior fossa group A ependymoma 5 | 468
Arthritis 4 | 290
Brain Ischemia 4 | 110
Cognitive delay 4 | 608
Diabetes Mellitus, Non-Insulin-Dependent 4 | 145
Diabetes Mellitus, Type 2 4 | 142
Familial atrial fibrillation 4 | 23
Frontal bossing 4 | 157
Heart disease 4 | 306
Kidney disease 4 | 430
Liver Cirrhosis 4 | 181
Liver Cirrhosis, Experimental 4 | 769
Mental and motor retardation 4 | 608
Multiple Sclerosis 4 | 540
Osteoporosis 4 | 363
Parkinson's disease 4 | 392
Prenatal onset 4 | 139
Status Epilepticus 4 | 98
Type 2 diabetes mellitus 4 | 272
Ventricular Fibrillation 4 | 17
atypical teratoid/rhabdoid tumor 4 | 357
esophageal adenocarcinoma 4 | 737
gastric carcinoma 4 | 807
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pediatric high grade glioma 4 | 1,064
primary pancreatic ductal adenocarcinoma 4 | 1,109

Tissue

Digestive Tract 54 | 17,369
Endocrine System 54 | 18,159
Female tissues 54 | 17,400
Male tissues 54 | 17,142
Nervous System 54 | 16,725
Urinary Tract 54 | 16,678
Blood and immune system 53 | 16,909
Liver and Pancreas 53 | 16,750
Respiratory system 53 | 16,393
Skin and soft tissues 53 | 17,230
Cardiovascular System 48 | 15,192

Target Family

Non-IDG 22 | 12,091
Enzyme 13 | 4,145
Ion Channel 9 | 344
Kinase 7 | 634
Epigenetic 1 | 242
GPCR 1 | 408
Transcription Factor 1 | 1,400
Transporter 1 | 473

GO Function

scaffold protein binding 55 | 55
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.46817 32.4 765
Triggering receptor expressed on myeloid cells 2 TREM2 Tbio Non-IDG -2.42594 269.9 370
Cytoplasmic protein NCK2 NCK2 Tbio Non-IDG -1.57587 36.4 241
Neuroligin-3 NLGN3 Tbio Enzyme -1.86262 71.5 179
Caspase-5 CASP5 Tchem Enzyme -2.01445 96.1 427
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440
SH3 and multiple ankyrin repeat domains protein 1 SHANK1 Tbio Non-IDG -1.58468 39.2 170
SH3 and multiple ankyrin repeat domains protein 3 SHANK3 Tbio Non-IDG -2.26648 182.9 0
Caspase-8 CASP8 Tchem Enzyme -3.54224 3121.4 1045
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.41690 2313.9 1252