Development Level

Tbio 20 | 10,625
Tclin 9 | 602
Tchem 8 | 1,890

IMPC Phenotype

preweaning lethality, complete... 4 | 633
abnormal behavior 2 | 226
decreased body weight 2 | 174
decreased total body fat amoun... 2 | 186
embryonic lethality prior to t... 2 | 187
increased circulating chloride... 2 | 43
abnormal femur morphology 1 | 14
abnormal gait 1 | 51
abnormal lens morphology 1 | 73
decreased bone mineral content 1 | 157
decreased circulating HDL chol... 1 | 77
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating magnesiu... 1 | 11
decreased effector memory CD8-... 1 | 24
decreased exploration in new e... 1 | 9
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased neutrophil cell numb... 1 | 37
hypoactivity 1 | 89
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 92
increased circulating phosphat... 1 | 24
increased eosinophil cell numb... 1 | 9
increased granulocyte number 1 | 8
increased grip strength 1 | 83
increased lean body mass 1 | 107
increased or absent threshold ... 1 | 128
increased respiratory quotient 1 | 12
increased rib number 1 | 41
preweaning lethality, incomple... 1 | 260
tremors 1 | 34

Disease

psoriasis 21 | 6,685
osteosarcoma 19 | 7,933
ovarian cancer 18 | 8,491
medulloblastoma, large-cell 15 | 6,234
glioblastoma 14 | 5,572
Carcinoma 13 | 2,147
atypical teratoid / rhabdoid tumor 12 | 4,369
lung carcinoma 12 | 2,844
Cancer 11 | 2,346
pilocytic astrocytoma 11 | 3,086
subependymal giant cell astrocytoma 11 | 2,287
lung cancer 10 | 4,473
malignant mesothelioma 10 | 3,163
Autistic Disorder 8 | 320
Intellectual disability 8 | 573
adult high grade glioma 8 | 2,148
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,289
invasive ductal carcinoma 8 | 2,950
lung adenocarcinoma 8 | 2,714
non-small cell lung cancer 8 | 2,798
primitive neuroectodermal tumor 8 | 3,031
Breast cancer 7 | 3,098
breast carcinoma 7 | 1,614
colon cancer 7 | 1,475
ependymoma 7 | 2,514
group 4 medulloblastoma 7 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
oligodendroglioma 7 | 2,849
posterior fossa group A ependymoma 7 | 1,511
Epilepsy 6 | 346
astrocytoma 6 | 1,493
diabetes mellitus 6 | 1,663
ductal carcinoma in situ 6 | 1,745
group 3 medulloblastoma 6 | 2,254
interstitial cystitis 6 | 2,299
ulcerative colitis 6 | 2,087
Long QT syndrome 5 | 53
Mammary Neoplasms 5 | 410
Neurodegenerative disease 5 | 383
atypical teratoid/rhabdoid tumor 5 | 1,095
cutaneous lupus erythematosus 5 | 1,056
juvenile dermatomyositis 5 | 1,189
pancreatic cancer 5 | 2,300
pediatric high grade glioma 5 | 2,712
pituitary cancer 5 | 1,972
posterior fossa group B ependymoma 5 | 1,530
sonic hedgehog group medulloblastoma 5 | 1,482
tuberculosis 5 | 1,563
Alzheimer's disease 4 | 644
Asperger syndrome 4 | 35
Schizophrenia 4 | 503
Status Epilepticus 4 | 85
acute quadriplegic myopathy 4 | 1,157
cystic fibrosis 4 | 1,670
Adenoid Cystic Carcinoma 3 | 99
Amyotrophic Lateral Sclerosis 3 | 432
Arrhythmogenic Right Ventricular Dysplasia 3 | 10
Atrial Fibrillation 3 | 110
Cardiomyopathy 3 | 110
Cardiomyopathy, Dilated 3 | 47
Cerebrovascular disease 3 | 231
Child Development Disorders, Pervasive 3 | 55
Congenital long QT syndrome 3 | 8
Eaton-Lambert syndrome 3 | 40
Familial atrial fibrillation 3 | 16
Heart conduction disease 3 | 65
Heart disease 3 | 279
IGA Glomerulonephritis 3 | 454
Long QT syndrome 1 3 | 12
Multiple Sclerosis 3 | 498
Neoplastic Cell Transformation 3 | 81
Prostatic Neoplasms 3 | 471
Romano-Ward Syndrome 3 | 12
Short QT syndrome 3 | 12
Sudden Cardiac Death 3 | 8
Sudden infant death syndrome 3 | 34
Timothy syndrome 3 | 12
Torsades de Pointes 3 | 5
Toxic encephalopathy 3 | 131
Ventricular Fibrillation 3 | 10
Waldenstrons macroglobulinemia 3 | 764
adrenocortical carcinoma 3 | 1,427
astrocytic glioma 3 | 2,241
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
chronic lymphocytic leukemia 3 | 244
esophageal adenocarcinoma 3 | 737
fibroadenoma 3 | 557
gastric carcinoma 3 | 832
hepatocellular carcinoma 3 | 550
medulloblastoma 3 | 1,524
pancreatic carcinoma 3 | 567
primary pancreatic ductal adenocarcinoma 3 | 1,271
Arthritis 2 | 248
Brain Ischemia 2 | 87
Diabetes Mellitus, Non-Insulin-Dependent 2 | 161
Down syndrome 2 | 548
Type 2 diabetes mellitus 2 | 192
Vascular disease 2 | 281
inflammatory breast cancer 2 | 404

Tissue

Blood and immune system 37 | 17,994
Cardiovascular System 37 | 17,957
Digestive Tract 37 | 18,472
Endocrine System 37 | 18,511
Female tissues 37 | 18,646
Liver and Pancreas 37 | 18,135
Male tissues 37 | 17,968
Nervous System 37 | 18,560
Urinary Tract 37 | 18,443
Respiratory system 36 | 17,483
Skin and soft tissues 36 | 18,114

Target Family

Non-IDG 13 | 11,969
Enzyme 8 | 4,146
Ion Channel 7 | 341
Kinase 6 | 634
Epigenetic 1 | 242
GPCR 1 | 408
Transporter 1 | 473

GO Function

scaffold protein binding 37 | 37
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine-threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
SH3 and multiple ankyrin repeat domains protein 1 SHANK1 Tbio Non-IDG -1.52802 34.3 167
SH3 and multiple ankyrin repeat domains protein 3 SHANK3 Tbio Non-IDG -2.21170 158.8 0
Potassium voltage-gated channel subfamily H member 2 KCNH2 Tclin Ion Channel -3.19173 1625.2 221
Triggering receptor expressed on myeloid cells 2 TREM2 Tbio Non-IDG -2.32637 219.6 297
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.87621 876.7 339
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.41371 28.0 678
Glutamate receptor ionotropic, delta-2 GRID2 Tbio Ion Channel -2.02679 111.0 70
Neuroligin-3 NLGN3 Tbio Enzyme -1.79390 63.4 157
Proto-oncogene tyrosine-protein kinase Src SRC Tclin Kinase -3.98540 8801.0 1257
Plasma membrane calcium-transporting ATPase 4 ATP2B4 Tbio Transporter -2.03962 108.5 109