Development Level

Tbio 11 | 11,445
Tchem 3 | 1,598

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavioral response t... 1 | 66
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal neural tube closure 1 | 46
decreased bone mineral content 1 | 151
decreased lean body mass 1 | 135
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
hypoactivity 1 | 132
increased bone mineral content 1 | 108
increased total body fat amoun... 1 | 134
increased urine magnesium leve... 1 | 2

Disease

ovarian cancer 10 | 8,520
Carcinoma 9 | 11,493
lung cancer 9 | 4,740
medulloblastoma, large-cell 8 | 6,241
Cancer 6 | 2,499
Multiple myeloma 6 | 1,332
osteosarcoma 6 | 7,950
psoriasis 6 | 6,694
atypical teratoid / rhabdoid tumor 5 | 5,112
glioblastoma 5 | 5,792
diabetes mellitus 4 | 1,728
group 3 medulloblastoma 4 | 4,104
Breast cancer 3 | 3,578
Colorectal Neoplasms 3 | 243
acute myeloid leukemia 3 | 783
acute quadriplegic myopathy 3 | 1,158
dermatomyositis 3 | 966
lung adenocarcinoma 3 | 2,716
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
Disease Models, Animal 2 | 155
Kidney cancer 2 | 2,613
adult high grade glioma 2 | 3,801
astrocytic glioma 2 | 2,597
ependymoma 2 | 4,679
malignant mesothelioma 2 | 3,232
mucosa-associated lymphoid tissue lymphoma 2 | 484
pancreatic cancer 2 | 2,398
progressive supranuclear palsy 2 | 676
Abdominal Pain 1 | 98
Acquired metabolic disease 1 | 336
Acute Promyelocytic Leukemia 1 | 40
Adenocarcinoma of lung 1 | 142
Alcohol dependence 1 | 107
Alpha 1-antitrypsin deficiency 1 | 11
Amyotrophic lateral sclerosis 1 | 451
Anemia 1 | 365
Bone pain 1 | 42
Breast Neoplasms 1 | 445
CHARGE syndrome 1 | 26
COPD 1 | 118
Carcinoma, Hepatocellular 1 | 228
Cardiomyopathy, Hypertrophic 1 | 24
Cell Transformation, Neoplastic 1 | 97
Choanal Atresia 1 | 42
Congenital diaphragmatic hernia 1 | 67
DOID:3858 1 | 6
Degenerative polyarthritis 1 | 115
Diarrhea 1 | 253
Epididymitis 1 | 8
Fever 1 | 138
Ganglioneuroma 1 | 13
Gaucher disease type 1 1 | 180
Hemoglobin low 1 | 124
Hypertrophic Cardiomyopathy 1 | 117
Hypoxia 1 | 33
IgG Deficiency 1 | 22
Immunoglobulin A deficiency (disorder) 1 | 19
Immunologic Deficiency Syndromes 1 | 113
Impaired Ig class-switch recombination (CSR) 1 | 3
Increased IgM levels 1 | 16
Increased susceptibility to bacterial infections 1 | 42
Infantile onset 1 | 238
Isolated cases 1 | 72
Leukemia, Acute Myeloid 1 | 17
Leukemia, Myelocytic, Acute 1 | 120
Leukemia, Myeloid, Acute 1 | 105
Leukemia, Promyelocytic, Acute 1 | 36
Liver carcinoma 1 | 240
Lymphadenopathy 1 | 62
Lymphoid leukemia 1 | 160
Lymphoma, T-Cell 1 | 13
Major Depressive Disorder 1 | 301
Mammary Neoplasms 1 | 425
Mesothelioma, Malignant 1 | 105
Myoclonus 1 | 74
Neoplasm Invasiveness 1 | 161
Neoplasm Metastasis 1 | 168
Neoplastic Cell Transformation 1 | 89
Neuroblastoma 1 | 80
Neurodevelopmental Disorders 1 | 70
Opsoclonus 1 | 5
Osteoarthritis 1 | 184
Precancerous Conditions 1 | 80
Prone to bacterial infection 1 | 42
Prostatic Intraepithelial Neoplasia 1 | 11
Prostatic Intraepithelial Neoplasias 1 | 11
Pyelonephritis 1 | 13
Recurrent bacterial infection 1 | 42
Stomach Neoplasms 1 | 300
T-Cell Lymphoma 1 | 13
Unipolar Depression 1 | 250
Weight decreased 1 | 103
Williams-Beuren syndrome 1 | 50
X- linked recessive 1 | 110
X-linked dominant 1 | 57
Xeroderma pigmentosum group B 1 | 20
hereditary spastic paraplegia 1 | 318
interstitial lung disease 1 | 298
non-small cell lung carcinoma 1 | 317

Tissue

Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678

Target Family

Non-IDG 7 | 12,091
Enzyme 4 | 4,145
Kinase 2 | 634
Transporter 1 | 473

GO Function

ribosomal small subunit bindin... 14 | 14
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP-binding cassette sub-family E member 1 ABCE1 Tbio Transporter -2.20865 163.9 238
Uracil-DNA glycosylase UNG Tbio Enzyme -2.82957 680.9 352
Nucleoside diphosphate kinase A NME1 Tbio Kinase -2.99077 863.1 945
ATP-dependent RNA helicase DDX3X DDX3X Tchem Enzyme -2.32036 221.7 479
Cytoplasmic polyadenylation element-binding protein 2 CPEB2 Tbio Non-IDG -0.98921 8.38 85
Translation initiation factor IF-2, mitochondrial MTIF2 Tbio Non-IDG -0.83675 7.75 63
Translation initiation factor IF-3, mitochondrial MTIF3 Tbio Non-IDG -1.07965 13.0 181
ATP-dependent RNA helicase DHX29 DHX29 Tbio Enzyme -1.00971 9.60 76
Eukaryotic translation initiation factor 4H EIF4H Tchem Non-IDG -1.26121 18.5 147
Serine/threonine-protein kinase pim-1 PIM1 Tchem Kinase -2.87679 758.8 531