Development Level

Tbio 27 | 11,651
Tchem 5 | 1,388
Tdark 1 | 6,593

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal behavior 3 | 298
abnormal tooth morphology 2 | 24
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating glucose ... 2 | 126
preweaning lethality, incomple... 2 | 499
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal esophagus morphology 1 | 5
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal rib morphology 1 | 10
brachydactyly 1 | 19
corneal opacity 1 | 32
decreased caudal vertebrae num... 1 | 53
decreased circulating alkaline... 1 | 46
decreased circulating fructosa... 1 | 30
decreased erythrocyte cell num... 1 | 62
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
enlarged gallbladder 1 | 2
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged spleen 1 | 41
fusion of vertebral arches 1 | 7
impaired righting response 1 | 26
increased NK cell number 1 | 3
increased circulating calcium ... 1 | 34
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased large unstained cell... 1 | 5
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
irregularly shaped pupil 1 | 7
prenatal lethality 1 | 28
small testis 1 | 58
syndactyly 1 | 23
tremors 1 | 39
vertebral fusion 1 | 23
vertebral transformation 1 | 12

Disease

Carcinoma 26 | 11,493
ovarian cancer 22 | 8,520
medulloblastoma, large-cell 15 | 6,241
osteosarcoma 15 | 7,950
psoriasis 13 | 6,694
lung cancer 12 | 4,740
glioblastoma 10 | 5,792
ependymoma 9 | 4,679
group 3 medulloblastoma 9 | 4,104
Intellectual disability 8 | 1,016
atypical teratoid / rhabdoid tumor 8 | 5,112
non-small cell lung cancer 8 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
Cancer 6 | 2,499
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
juvenile dermatomyositis 6 | 1,187
malignant mesothelioma 6 | 3,232
oligodendroglioma 6 | 2,850
spina bifida 6 | 1,074
Kidney cancer 5 | 2,613
Pick disease 5 | 1,894
Rheumatoid arthritis 5 | 1,191
cystic fibrosis 5 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
primitive neuroectodermal tumor 5 | 3,035
Broad flat nasal bridge 4 | 236
Dull intelligence 4 | 645
Epilepsy 4 | 792
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Multiple myeloma 4 | 1,332
Nasal bridge wide 4 | 236
Poor school performance 4 | 645
adrenocortical carcinoma 4 | 1,428
dermatomyositis 4 | 966
diabetes mellitus 4 | 1,728
Astrocytoma, Pilocytic 3 | 3,081
Blind Vision 3 | 111
Blindness, Legal 3 | 110
Breast cancer 3 | 3,578
Cataract 3 | 297
Cognitive delay 3 | 608
Glaucoma 3 | 239
Global developmental delay 3 | 608
Growth Disorders 3 | 35
Lens Opacities 3 | 231
Mental and motor retardation 3 | 608
Microcephaly 3 | 166
Prostate cancer 3 | 175
Prostatic Neoplasms 3 | 495
Skin Neoplasms 3 | 69
Strabismus 3 | 270
Waldenstrons macroglobulinemia 3 | 765
active Crohn's disease 3 | 922
acute quadriplegic myopathy 3 | 1,158
adult high grade glioma 3 | 3,801
astrocytic glioma 3 | 2,597
breast carcinoma 3 | 1,638
gastric cancer 3 | 459
group 4 medulloblastoma 3 | 1,855
invasive ductal carcinoma 3 | 2,951
lung adenocarcinoma 3 | 2,716
pancreatic cancer 3 | 2,398
pituitary cancer 3 | 1,972
sarcoidosis 3 | 370
sonic hedgehog group medulloblastoma 3 | 467
subependymal giant cell astrocytoma 3 | 2,287
Acquired scoliosis 2 | 281
Alzheimer's disease 2 | 658
Amyotrophic lateral sclerosis 2 | 451
Anteverted nostril 2 | 191
Bilateral fifth finger clinodactyly 2 | 110
Byzanthine arch palate 2 | 194
Congenital Epicanthus 2 | 177
Congenital clubfoot 2 | 109
Congenital pes cavus 2 | 88
Curvature of little finger 2 | 110
Curvature of spine 2 | 282
Large auricle 2 | 87
Large dysplastic ears 2 | 87
Large pinnae 2 | 87
Large prominent ears 2 | 87
Large protruding ears 2 | 87
Large, floppy ears 2 | 87
Liver Cirrhosis, Experimental 2 | 769
Macrotia 2 | 87
Melanoma 2 | 711
Microstomia 2 | 78
Multiple Sclerosis 2 | 540
Muscle Spasticity 2 | 195
Prominent ear 2 | 56
Protruding ears 2 | 56
Seizures 2 | 596
Sparse hair 2 | 59
astrocytoma 2 | 1,146
hepatocellular carcinoma 2 | 547
nasopharyngeal carcinoma 2 | 1,058
pancreatic carcinoma 2 | 562
tuberculosis 2 | 2,010

Tissue

Digestive Tract 33 | 17,369
Cardiovascular System 32 | 15,192
Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Liver and Pancreas 32 | 16,750
Male tissues 32 | 17,142
Skin and soft tissues 32 | 17,230
Urinary Tract 32 | 16,678
Blood and immune system 31 | 16,909
Nervous System 31 | 16,725
Respiratory system 31 | 16,393

Target Family

Non-IDG 14 | 12,091
Enzyme 9 | 4,145
Epigenetic 5 | 242
Kinase 4 | 634
Transcription Factor 1 | 1,400

GO Function

ribonucleoprotein complex bind... 33 | 33
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
U4/U6 small nuclear ribonucleoprotein Prp31 PRPF31 Tbio Non-IDG -1.84397 72.4 216
DNA topoisomerase 2-beta TOP2B Tchem Enzyme -2.47190 253.5 190
Pre-mRNA-processing factor 6 PRPF6 Tbio Non-IDG -1.39926 24.5 171
Interferon-induced helicase C domain-containing protein 1 IFIH1 Tbio Enzyme -2.67869 455.3 335
Pituitary homeobox 2 PITX2 Tbio Transcription Factor -2.67290 480.0 220
Casein kinase II subunit beta CSNK2B Tbio Kinase -2.72925 527.4 422
C->U-editing enzyme APOBEC-1 APOBEC1 Tbio Non-IDG -2.02305 96.3 122
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.41690 2313.9 1252
Mitochondrial import inner membrane translocase subunit TIM50 TIMM50 Tbio Enzyme -1.40569 28.4 128
E3 ubiquitin-protein ligase RNF135 RNF135 Tbio Enzyme -1.25282 18.3 115