Development Level

Tbio 7 | 11,445
Tclin 5 | 613
Tchem 4 | 1,598

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavior 2 | 298
decreased total body fat amoun... 2 | 207
preweaning lethality, incomple... 2 | 499
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal motor capabilities-co... 1 | 5
abnormal retina morphology 1 | 71
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased fasted circulating g... 1 | 65
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
hemorrhage 1 | 23
hyperactivity 1 | 148
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating triglyce... 1 | 42
increased lactate dehydrogenas... 1 | 3
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
short tibia 1 | 97

Disease

Carcinoma 13 | 11,493
osteosarcoma 11 | 7,950
Cancer 9 | 2,499
ovarian cancer 9 | 8,520
medulloblastoma, large-cell 8 | 6,241
psoriasis 8 | 6,694
Obesity 6 | 678
lung cancer 6 | 4,740
Schizophrenia 5 | 1,160
atypical teratoid / rhabdoid tumor 5 | 5,112
diabetes mellitus 5 | 1,728
glioblastoma 5 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
lung carcinoma 5 | 2,843
malignant mesothelioma 5 | 3,232
pancreatic cancer 5 | 2,398
Breast Neoplasms 4 | 445
Breast cancer 4 | 3,578
Carcinoma, Hepatocellular 4 | 228
Kidney cancer 4 | 2,613
Liver carcinoma 4 | 240
Mammary Neoplasms 4 | 425
aldosterone-producing adenoma 4 | 665
group 4 medulloblastoma 4 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
invasive ductal carcinoma 4 | 2,951
tuberculosis 4 | 2,010
ulcerative colitis 4 | 1,819
Autosomal recessive predisposition 3 | 1,442
Cholestasis 3 | 155
Endometriosis 3 | 540
Fatty liver disease 3 | 103
Intellectual disability 3 | 1,016
Liver disease 3 | 237
Rheumatoid arthritis 3 | 1,191
Waldenstrons macroglobulinemia 3 | 765
astrocytoma 3 | 1,146
ductal carcinoma in situ 3 | 1,745
ependymoma 3 | 4,679
esophageal adenocarcinoma 3 | 737
hepatocellular carcinoma 3 | 547
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
lung adenocarcinoma 3 | 2,716
nephrosclerosis 3 | 333
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pituitary cancer 3 | 1,972
primitive neuroectodermal tumor 3 | 3,035
Acne vulgaris 2 | 14
Acquired metabolic disease 2 | 336
Adenocarcinoma 2 | 122
Alzheimer's disease 2 | 658
Amyotrophic lateral sclerosis 2 | 451
Arthritis 2 | 290
Bipolar Disorder 2 | 666
Colorectal Neoplasms 2 | 243
Crohn Disease 2 | 45
Dementia 2 | 175
Depressive disorder 2 | 409
Dermatologic disorders 2 | 93
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Noninsulin-Dependent 2 | 31
Diabetes Mellitus, Type 2 2 | 142
Dysarthria 2 | 192
Heart failure 2 | 162
Hepatomegaly 2 | 285
Highly variable clinical phenotype 2 | 150
Highly variable phenotype and severity 2 | 150
Highly variable phenotype, even within families 2 | 150
Hyperglycemia 2 | 137
Hyperkeratosis 2 | 50
Hypertension 2 | 396
Inflammatory bowel disease 2 | 151
Insulin Resistance 2 | 72
Kidney disease 2 | 430
Leber congenital amaurosis 2 | 69
Liver neoplasms 2 | 130
Melanoma 2 | 711
Multiple Sclerosis 2 | 540
Nerve Degeneration 2 | 121
Neurodegenerative disease 2 | 414
Neuronal loss 2 | 25
Osteoporosis 2 | 363
Parkinson's disease 2 | 392
Phenotypic variability 2 | 150
Pick disease 2 | 1,894
Prostatic Neoplasms 2 | 495
Stomach Neoplasms 2 | 300
Type 2 diabetes mellitus 2 | 272
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
astrocytic glioma 2 | 2,597
cystic fibrosis 2 | 1,696
fibroadenoma 2 | 559
pediatric high grade glioma 2 | 1,064
progressive supranuclear palsy 2 | 676
urothelial carcinoma 2 | 318

Tissue

Blood and immune system 16 | 16,909
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Respiratory system 16 | 16,393
Skin and soft tissues 16 | 17,230
Urinary Tract 16 | 16,678
Cardiovascular System 15 | 15,192
Male tissues 15 | 17,142
Nervous System 14 | 16,725

Target Family

Nuclear Receptor 8 | 48
Non-IDG 3 | 12,091
Epigenetic 2 | 242
Transcription Factor 2 | 1,400
Enzyme 1 | 4,145

GO Function

retinoid X receptor binding 16 | 16
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Peroxisome proliferator-activated receptor gamma PPARG Tclin Nuclear Receptor -3.96393 9579.5 773
Vitamin D3 receptor VDR Tclin Nuclear Receptor -3.62166 3805.7 575
RNA-binding protein FUS FUS Tbio Non-IDG -3.17908 1494.0 267
Nuclear receptor subfamily 0 group B member 2 NR0B2 Tchem Nuclear Receptor -2.77179 598.3 299
High mobility group protein HMG-I/HMG-Y HMGA1 Tbio Transcription Factor -2.59141 433.8 253
Nuclear receptor subfamily 4 group A member 2 NR4A2 Tchem Nuclear Receptor -2.59490 415.4 307
Bile acid receptor NR1H4 Tclin Nuclear Receptor -2.57379 350.3 293
Retinoic acid receptor beta RARB Tclin Nuclear Receptor -2.51618 295.9 391
Nuclear receptor coactivator 1 NCOA1 Tchem Epigenetic -2.36613 239.2 307
Nuclear receptor-interacting protein 1 NRIP1 Tbio Non-IDG -2.21323 183.8 155