Development Level

Tbio 7 | 11,445
Tclin 5 | 613
Tchem 4 | 1,598

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavior 2 | 298
decreased total body fat amoun... 2 | 207
preweaning lethality, incomple... 2 | 499
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal motor capabilities-co... 1 | 5
abnormal retina morphology 1 | 71
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased fasted circulating g... 1 | 65
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
hemorrhage 1 | 23
hyperactivity 1 | 148
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating triglyce... 1 | 42
increased lactate dehydrogenas... 1 | 3
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
short tibia 1 | 97

Disease

Carcinoma 13 | 11,493
osteosarcoma 11 | 7,950
Cancer 9 | 2,499
ovarian cancer 9 | 8,520
medulloblastoma, large-cell 8 | 6,241
psoriasis 8 | 6,694
Obesity 6 | 678
lung cancer 6 | 4,740
Schizophrenia 5 | 1,160
atypical teratoid / rhabdoid tumor 5 | 5,112
diabetes mellitus 5 | 1,728
glioblastoma 5 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
lung carcinoma 5 | 2,843
malignant mesothelioma 5 | 3,232
pancreatic cancer 5 | 2,398
Breast Neoplasms 4 | 445
Breast cancer 4 | 3,578
Carcinoma, Hepatocellular 4 | 228
Kidney cancer 4 | 2,613
Liver carcinoma 4 | 240
Mammary Neoplasms 4 | 425
aldosterone-producing adenoma 4 | 665
group 4 medulloblastoma 4 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
invasive ductal carcinoma 4 | 2,951
tuberculosis 4 | 2,010
ulcerative colitis 4 | 1,819
Autosomal recessive predisposition 3 | 1,442
Cholestasis 3 | 155
Endometriosis 3 | 540
Fatty liver disease 3 | 103
Intellectual disability 3 | 1,016
Liver disease 3 | 237
Rheumatoid arthritis 3 | 1,191
Waldenstrons macroglobulinemia 3 | 765
astrocytoma 3 | 1,146
ductal carcinoma in situ 3 | 1,745
ependymoma 3 | 4,679
esophageal adenocarcinoma 3 | 737
hepatocellular carcinoma 3 | 547
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
lung adenocarcinoma 3 | 2,716
nephrosclerosis 3 | 333
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pituitary cancer 3 | 1,972
primitive neuroectodermal tumor 3 | 3,035
Acne vulgaris 2 | 14
Acquired metabolic disease 2 | 336
Adenocarcinoma 2 | 122
Alzheimer's disease 2 | 658
Amyotrophic lateral sclerosis 2 | 451
Arthritis 2 | 290
Bipolar Disorder 2 | 666
Colorectal Neoplasms 2 | 243
Crohn Disease 2 | 45
Dementia 2 | 175
Depressive disorder 2 | 409
Dermatologic disorders 2 | 93
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Noninsulin-Dependent 2 | 31
Diabetes Mellitus, Type 2 2 | 142
Dysarthria 2 | 192
Heart failure 2 | 162
Hepatomegaly 2 | 285
Highly variable clinical phenotype 2 | 150
Highly variable phenotype and severity 2 | 150
Highly variable phenotype, even within families 2 | 150
Hyperglycemia 2 | 137
Hyperkeratosis 2 | 50
Hypertension 2 | 396
Inflammatory bowel disease 2 | 151
Insulin Resistance 2 | 72
Kidney disease 2 | 430
Leber congenital amaurosis 2 | 69
Liver neoplasms 2 | 130
Melanoma 2 | 711
Multiple Sclerosis 2 | 540
Nerve Degeneration 2 | 121
Neurodegenerative disease 2 | 414
Neuronal loss 2 | 25
Osteoporosis 2 | 363
Parkinson's disease 2 | 392
Phenotypic variability 2 | 150
Pick disease 2 | 1,894
Prostatic Neoplasms 2 | 495
Stomach Neoplasms 2 | 300
Type 2 diabetes mellitus 2 | 272
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
astrocytic glioma 2 | 2,597
cystic fibrosis 2 | 1,696
fibroadenoma 2 | 559
pediatric high grade glioma 2 | 1,064
progressive supranuclear palsy 2 | 676
urothelial carcinoma 2 | 318

Tissue

Blood and immune system 16 | 16,909
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Respiratory system 16 | 16,393
Skin and soft tissues 16 | 17,230
Urinary Tract 16 | 16,678
Cardiovascular System 15 | 15,192
Male tissues 15 | 17,142
Nervous System 14 | 16,725

Target Family

Nuclear Receptor 8 | 48
Non-IDG 3 | 12,091
Epigenetic 2 | 242
Transcription Factor 2 | 1,400
Enzyme 1 | 4,145

GO Function

retinoid X receptor binding 16 | 16
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mediator of RNA polymerase II transcription subunit 25 MED25 Tbio Enzyme -1.76765 57.1 86
Nuclear receptor-interacting protein 1 NRIP1 Tbio Non-IDG -2.21323 183.8 155
Nuclear receptor subfamily 4 group A member 2 NR4A2 Tchem Nuclear Receptor -2.59490 415.4 307
Vitamin D3 receptor VDR Tclin Nuclear Receptor -3.62166 3805.7 575
AT-rich interactive domain-containing protein 5A ARID5A Tbio Transcription Factor -0.56704 5.22 152
Nuclear receptor coactivator 6 NCOA6 Tbio Non-IDG -1.83369 72.1 54
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific NSD1 Tbio Epigenetic -2.16239 142.5 123
Bile acid receptor NR1H4 Tclin Nuclear Receptor -2.57379 350.3 293
Retinoic acid receptor gamma RARG Tclin Nuclear Receptor -2.13866 127.0 126
Peroxisome proliferator-activated receptor gamma PPARG Tclin Nuclear Receptor -3.96393 9579.5 773