Development Level

Tbio 265 | 11,651
Tchem 61 | 1,388
Tclin 32 | 612
Tdark 16 | 6,593

Collection

RFA-RM-18-021 2 | 328
Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 16 | 979
preweaning lethality, incomple... 14 | 499
enlarged heart 11 | 210
decreased vertical activity 9 | 208
decreased total body fat amoun... 8 | 207
increased total body fat amoun... 7 | 134
abnormal heart morphology 6 | 162
decreased circulating choleste... 6 | 93
decreased lean body mass 6 | 135
abnormal behavior 5 | 298
decreased lymphocyte cell numb... 5 | 83
increased circulating alkaline... 5 | 122
abnormal bone structure 4 | 187
abnormal embryo size 4 | 220
abnormal eye morphology 4 | 68
abnormal seminal vesicle morph... 4 | 114
decreased body weight 4 | 161
decreased grip strength 4 | 116
increased neutrophil cell numb... 4 | 46
increased startle reflex 4 | 112
abnormal skin morphology 3 | 50
abnormal testis morphology 3 | 43
decreased circulating glucose ... 3 | 126
decreased circulating insulin ... 3 | 76
decreased leukocyte cell numbe... 3 | 73
decreased mean corpuscular vol... 3 | 79
embryonic lethality prior to o... 3 | 239
hypoactivity 3 | 132
increased circulating amylase ... 3 | 25
increased lean body mass 3 | 172
increased lymphocyte cell numb... 3 | 32
small testis 3 | 58
thrombocytopenia 3 | 56
abnormal gait 2 | 69
abnormal maxilla morphology 2 | 17
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased circulating HDL chol... 2 | 68
decreased circulating calcium ... 2 | 36
decreased circulating glycerol... 2 | 16
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased eosinophil cell numb... 2 | 24
decreased fasted circulating g... 2 | 65
decreased heart weight 2 | 27
decreased large unstained cell... 2 | 11
decreased startle reflex 2 | 75
decreased threshold for audito... 2 | 26
embryonic lethality prior to t... 2 | 278
enlarged uterus 2 | 11
increased blood urea nitrogen ... 2 | 48
increased circulating sodium l... 2 | 71
increased heart weight 2 | 62
increased leukocyte cell numbe... 2 | 47
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
small superior vagus ganglion 2 | 74
tremors 2 | 39
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal head morphology 1 | 10
abnormal lung morphology 1 | 26
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal tail movements 1 | 12
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
absent vibrissae 1 | 12
convulsive seizures 1 | 13
corneal opacity 1 | 32
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased circulating triglyce... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased pulmonary respirator... 1 | 5
decreased total retina thickne... 1 | 17
enlarged spleen 1 | 41
enlarged stomach 1 | 2
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
persistence of hyaloid vascula... 1 | 33
small thymus 1 | 16
thin ventricular wall 1 | 24

Disease

Carcinoma 217 | 11,493
ovarian cancer 178 | 8,520
osteosarcoma 161 | 7,950
glioblastoma 156 | 5,792
psoriasis 156 | 6,694
Cancer 139 | 2,499
medulloblastoma, large-cell 126 | 6,241
lung cancer 122 | 4,740
atypical teratoid / rhabdoid tumor 111 | 5,112
ependymoma 100 | 4,679
malignant mesothelioma 97 | 3,232
Astrocytoma, Pilocytic 96 | 3,081
interstitial cystitis 91 | 2,312
adult high grade glioma 90 | 3,801
group 3 medulloblastoma 88 | 4,104
invasive ductal carcinoma 86 | 2,951
lung carcinoma 83 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 81 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 80 | 2,989
Breast cancer 76 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 76 | 3,291
ulcerative colitis 76 | 1,819
non-small cell lung cancer 74 | 2,890
diabetes mellitus 73 | 1,728
oligodendroglioma 72 | 2,850
pancreatic cancer 70 | 2,398
lung adenocarcinoma 65 | 2,716
tuberculosis 64 | 2,010
primitive neuroectodermal tumor 62 | 3,035
subependymal giant cell astrocytoma 58 | 2,287
Schizophrenia 57 | 1,160
cystic fibrosis 57 | 1,696
colon cancer 55 | 1,478
Autosomal recessive predisposition 53 | 1,442
Kidney cancer 53 | 2,613
Liver Cirrhosis, Experimental 53 | 769
pancreatic ductal adenocarcinoma liver metastasis 53 | 1,962
astrocytic glioma 52 | 2,597
ductal carcinoma in situ 49 | 1,745
Rheumatoid arthritis 47 | 1,191
pituitary cancer 45 | 1,972
cutaneous lupus erythematosus 44 | 1,057
Kidney disease 42 | 430
breast carcinoma 40 | 1,638
Hypertension 39 | 396
Obesity 37 | 678
adrenocortical carcinoma 37 | 1,428
astrocytoma 37 | 1,146
Bipolar Disorder 36 | 666
group 4 medulloblastoma 36 | 1,855
pediatric high grade glioma 35 | 1,064
Pick disease 34 | 1,894
juvenile dermatomyositis 34 | 1,187
Atherosclerosis 33 | 291
Multiple myeloma 33 | 1,332
primary pancreatic ductal adenocarcinoma 32 | 1,109
Depressive disorder 31 | 409
Alzheimer's disease 30 | 658
Arthritis 30 | 290
Atopic dermatitis 30 | 952
Cerebrovascular disease 30 | 238
Hypertensive disease 29 | 292
dermatomyositis 28 | 966
Coronary artery disease 27 | 268
Multiple Sclerosis 27 | 540
Epilepsy 26 | 792
Vascular disease 26 | 319
fibroadenoma 26 | 559
primary Sjogren syndrome 26 | 735
spina bifida 26 | 1,074
Heart disease 25 | 306
active Crohn's disease 25 | 922
nasopharyngeal carcinoma 25 | 1,058
Breast Neoplasms 24 | 445
Mammary Neoplasms 24 | 425
Asthma 23 | 385
gastric carcinoma 23 | 807
Osteoporosis 22 | 363
Prostatic Neoplasms 22 | 495
active ulcerative colitis 22 | 764
acute quadriplegic myopathy 22 | 1,158
Anemia 21 | 365
Down syndrome 21 | 499
Duchenne muscular dystrophy 20 | 601
Melanoma 20 | 711
Seizures 20 | 596
Hypersensitivity reaction type II disease 19 | 253
Liver disease 19 | 237
Lung disease 19 | 142
Major Depressive Disorder 19 | 301
Mental Depression 19 | 333
Polycystic ovary syndrome 19 | 360
Waldenstrons macroglobulinemia 19 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 19 | 510
posterior fossa group A ependymoma 19 | 468
Crohn's disease 18 | 321
Diarrhea 18 | 253
Hepatomegaly 17 | 285
esophageal adenocarcinoma 17 | 737
hepatocellular carcinoma 17 | 547

Tissue

Endocrine System 359 | 18,159
Digestive Tract 357 | 17,369
Female tissues 351 | 17,400
Skin and soft tissues 351 | 17,230
Liver and Pancreas 347 | 16,750
Blood and immune system 344 | 16,909
Male tissues 342 | 17,142
Urinary Tract 342 | 16,678
Nervous System 341 | 16,725
Respiratory system 333 | 16,393
Cardiovascular System 300 | 15,192

Target Family

Non-IDG 256 | 12,091
Enzyme 64 | 4,145
Kinase 28 | 634
Ion Channel 8 | 344
Transporter 7 | 473
GPCR 5 | 408
Nuclear Receptor 4 | 48
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

GO Function

receptor binding 374 | 374
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
Tyrosine-protein kinase ZAP-70 ZAP70 Tchem Kinase -2.91589 798.2 1515
Agouti-signaling protein ASIP Tbio Non-IDG -1.78281 57.2 34
CD160 antigen CD160 Tbio Non-IDG -1.70035 55.1 428
Apolipoprotein F APOF Tbio Non-IDG -1.45156 33.3 232
Tyrosine-protein kinase JAK3 JAK3 Tclin Kinase -2.64385 453.7 292
Integrin beta-8 ITGB8 Tbio Non-IDG -1.47947 27.7 99
Zinc transporter ZIP1 SLC39A1 Tbio Transporter -1.89903 75.9 61
Angiopoietin-related protein 2 ANGPTL2 Tbio Non-IDG -1.79753 80.1 185