Development Level

Tbio 198 | 10,625
Tchem 74 | 1,890
Tclin 22 | 602
Tdark 9 | 7,003

Collection

Eligible Ion Channel Proteins 1 | 117
Eligible Kinase Proteins 1 | 134

IMPC Term

enlarged heart 9 | 111
preweaning lethality, complete... 8 | 633
decreased total body fat amoun... 5 | 186
increased circulating alkaline... 5 | 119
abnormal behavior 4 | 226
abnormal heart morphology 4 | 51
abnormal seminal vesicle morph... 4 | 47
decreased grip strength 4 | 123
increased grip strength 4 | 83
abnormal embryo size 3 | 112
abnormal testis morphology 3 | 30
decreased body weight 3 | 174
decreased circulating choleste... 3 | 85
decreased lumbar vertebrae num... 3 | 62
increased lean body mass 3 | 107
preweaning lethality, incomple... 3 | 260
small testis 3 | 37
abnormal bone structure 2 | 131
abnormal kidney morphology 2 | 30
decreased circulating HDL chol... 2 | 77
decreased circulating calcium ... 2 | 33
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased fasted circulating g... 2 | 49
decreased lean body mass 2 | 195
increased blood urea nitrogen ... 2 | 44
increased bone mineral content 2 | 92
increased circulating HDL chol... 2 | 63
increased or absent threshold ... 2 | 128
short tibia 2 | 82
thrombocytopenia 2 | 46
tremors 2 | 34
abnormal behavioral response t... 1 | 52
abnormal clavicle morphology 1 | 5
abnormal coping response 1 | 12
abnormal cranium morphology 1 | 32
abnormal digit morphology 1 | 13
abnormal duodenum morphology 1 | 1
abnormal eye morphology 1 | 38
abnormal femur morphology 1 | 14
abnormal hair texture 1 | 4
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 20
abnormal incisor morphology 1 | 3
abnormal locomotor activation 1 | 26
abnormal lung morphology 1 | 15
abnormal maxilla morphology 1 | 16
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal skin morphology 1 | 23
abnormal tail movements 1 | 12
abnormal vibrissa morphology 1 | 17
abnormal vocalization 1 | 21
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating aspartat... 1 | 27
decreased circulating bilirubi... 1 | 14
decreased circulating fructosa... 1 | 31
decreased circulating glycerol... 1 | 19
decreased circulating insulin ... 1 | 75
decreased monocyte cell number 1 | 28
decreased prepulse inhibition 1 | 52
decreased pulmonary respirator... 1 | 4
decreased rib number 1 | 59
decreased startle reflex 1 | 48
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged spleen 1 | 26
enlarged stomach 1 | 2
female infertility 1 | 34
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
impaired righting response 1 | 19
increased body length 1 | 20
increased circulating amylase ... 1 | 13
increased circulating fructosa... 1 | 11
increased circulating glycerol... 1 | 11
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased circulating thyroxin... 1 | 7
increased circulating triglyce... 1 | 24
increased eosinophil cell numb... 1 | 9
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased fluid intake 1 | 1
increased heart weight 1 | 37
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased lymphocyte cell numb... 1 | 9
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased respiratory quotient 1 | 12
increased sacral vertebrae num... 1 | 62
lethargy 1 | 5
oligodactyly 1 | 14
premature death 1 | 5
small thymus 1 | 11

Disease

ovarian cancer 145 | 8,484
psoriasis 129 | 6,685
osteosarcoma 127 | 7,933
glioblastoma 121 | 5,572
Cancer 114 | 2,346
medulloblastoma, large-cell 104 | 6,234
lung cancer 95 | 4,466
interstitial cystitis 81 | 2,299
atypical teratoid / rhabdoid tumor 78 | 4,369
malignant mesothelioma 77 | 3,162
pilocytic astrocytoma 76 | 3,086
invasive ductal carcinoma 74 | 2,950
ulcerative colitis 72 | 2,087
intraductal papillary-mucinous adenoma (IPMA) 70 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 69 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 67 | 2,988
lung carcinoma 66 | 2,844
pediatric high grade glioma 62 | 2,712
diabetes mellitus 60 | 1,663
oligodendroglioma 58 | 2,849
non-small cell lung cancer 57 | 2,798
Breast cancer 53 | 3,094
lung adenocarcinoma 52 | 2,713
pancreatic cancer 51 | 2,300
primitive neuroectodermal tumor 51 | 3,031
colon cancer 48 | 1,475
subependymal giant cell astrocytoma 46 | 2,287
cystic fibrosis 45 | 1,665
pancreatic ductal adenocarcinoma liver metastasis 42 | 1,795
group 4 medulloblastoma 41 | 1,875
tuberculosis 41 | 1,557
astrocytoma 40 | 1,493
pituitary cancer 40 | 1,972
posterior fossa group A ependymoma 39 | 1,511
Rheumatoid Arthritis 38 | 1,160
cutaneous lupus erythematosus 37 | 1,056
ductal carcinoma in situ 37 | 1,745
ependymoma 37 | 2,514
Kidney disease 36 | 396
Carcinoma 35 | 2,147
adult high grade glioma 35 | 2,148
adrenocortical carcinoma 32 | 1,427
breast carcinoma 32 | 1,614
group 3 medulloblastoma 31 | 2,254
Obesity 30 | 616
Pick disease 30 | 1,893
astrocytic glioma 30 | 2,241
Atherosclerosis 28 | 275
Hypertension 28 | 287
juvenile dermatomyositis 28 | 1,189
primary pancreatic ductal adenocarcinoma 28 | 1,271
Atopic dermatitis 27 | 944
Multiple myeloma 27 | 1,327
Alzheimer's disease 26 | 644
Cerebrovascular disease 26 | 231
posterior fossa group B ependymoma 26 | 1,530
sonic hedgehog group medulloblastoma 25 | 1,482
dermatomyositis 24 | 933
active Crohn's disease 23 | 918
gastric carcinoma 23 | 832
primary Sjogren syndrome 23 | 789
Coronary artery disease 22 | 240
Hypertensive disease 22 | 193
Multiple Sclerosis 22 | 498
Vascular disease 22 | 281
fibroadenoma 22 | 557
Mammary Neoplasms 21 | 410
medulloblastoma 21 | 1,524
nasopharyngeal carcinoma 21 | 1,056
Asthma 20 | 349
Heart disease 20 | 279
Arthritis 18 | 248
Down syndrome 18 | 548
Lung disease 18 | 132
Prostatic Neoplasms 18 | 471
atypical teratoid/rhabdoid tumor 18 | 1,095
spina bifida 18 | 1,064
Duchenne muscular dystrophy 17 | 602
Polycystic Ovary Syndrome 17 | 332
Waldenstrons macroglobulinemia 17 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 17 | 499
Schizophrenia 16 | 501
acute quadriplegic myopathy 16 | 1,157
esophageal adenocarcinoma 16 | 737
mucosa-associated lymphoid tissue lymphoma 16 | 480
Autistic Disorder 15 | 320
Heart failure 15 | 80
Hypersensitivity reaction type II disease 15 | 235
Metabolic syndrome X 15 | 155
aldosterone-producing adenoma 15 | 664
Anemia 14 | 252
Hyperglycemia 14 | 120
nephrosclerosis 14 | 329
Crohn's disease 13 | 304
Hypoglycemia 13 | 81
Liver Cirrhosis, Experimental 13 | 108
Osteoporosis 13 | 257
hepatocellular carcinoma 13 | 532
Myocardial Ischemia 12 | 169
acute myeloid leukemia 12 | 780

Tissue

Digestive Tract 299 | 18,473
Endocrine System 298 | 18,512
Female tissues 298 | 18,647
Nervous System 298 | 18,561
Skin and soft tissues 297 | 18,115
Liver and Pancreas 296 | 18,136
Urinary Tract 295 | 18,444
Blood and immune system 293 | 17,995
Cardiovascular System 292 | 17,958
Respiratory system 292 | 17,484
Male tissues 289 | 17,969

Target Family

Non-IDG 201 | 11,971
Enzyme 60 | 4,146
Kinase 23 | 634
Ion Channel 6 | 341
Transporter 5 | 473
Nuclear Receptor 4 | 48
GPCR 3 | 406
Epigenetic 1 | 242

GO Function

receptor binding 303 | 303
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Muellerian-inhibiting factor AMH Tbio Non-IDG -3.34520 2413.2 212
Teratocarcinoma-derived growth factor 1 TDGF1 Tbio Non-IDG 156.3 371
Angiogenin ANG Tbio Enzyme -2.89794 796.0 203
Interferon lambda-1 IFNL1 Tbio Non-IDG -1.90881 86.4 137
Peroxisomal multifunctional enzyme type 2 HSD17B4 Tbio Non-IDG -2.15826 152.2 203
Lymphotoxin-alpha LTA Tbio Non-IDG -2.84770 612.8 461
Transmembrane channel-like protein 8 TMC8 Tbio Ion Channel -1.45295 32.2 147
Pro-neuropeptide Y NPY Tbio Non-IDG -3.81741 7285.3 401
Protein-tyrosine kinase 6 PTK6 Tchem Kinase -2.14303 167.1 320