Development Level

Tbio 140 | 11,445
Tchem 32 | 1,598
Tclin 20 | 613
Tdark 10 | 6,588

Collection

GPCR: IDG Consortium (Targets) 2 | 126
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, incomple... 10 | 499
decreased vertical activity 9 | 208
preweaning lethality, complete... 9 | 979
embryonic lethality prior to t... 7 | 278
abnormal bone structure 5 | 187
abnormal embryo size 5 | 220
enlarged heart 5 | 210
increased lean body mass 5 | 172
decreased fasted circulating g... 4 | 65
decreased grip strength 4 | 116
embryonic lethality prior to o... 4 | 239
increased leukocyte cell numbe... 4 | 47
pale yolk sac 4 | 25
small superior vagus ganglion 4 | 74
abnormal heart morphology 3 | 162
abnormal pericardium morpholog... 3 | 26
abnormal seminal vesicle morph... 3 | 114
decreased circulating alkaline... 3 | 46
decreased lymphocyte cell numb... 3 | 83
decreased total body fat amoun... 3 | 207
embryonic growth retardation 3 | 106
impaired glucose tolerance 3 | 75
increased bone mineral content 3 | 108
increased circulating alkaline... 3 | 122
pallor 3 | 34
abnormal behavior 2 | 298
abnormal eye anterior chamber ... 2 | 9
abnormal eye morphology 2 | 68
abnormal forebrain development 2 | 20
abnormal kidney morphology 2 | 65
abnormal limb bud morphology 2 | 17
abnormal neural tube closure 2 | 46
abnormal placenta size 2 | 20
abnormal retinal vasculature m... 2 | 27
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased circulating fructosa... 2 | 30
decreased heart rate 2 | 18
decreased lean body mass 2 | 135
decreased mean corpuscular vol... 2 | 79
enlarged kidney 2 | 14
enlarged spleen 2 | 41
enlarged uterus 2 | 11
female infertility 2 | 60
improved glucose tolerance 2 | 79
increased circulating chloride... 2 | 41
increased grip strength 2 | 41
increased lymphocyte cell numb... 2 | 32
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
male infertility 2 | 123
prolonged RR interval 2 | 8
tremors 2 | 39
abnormal blood vessel morpholo... 1 | 5
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal lens morphology 1 | 81
abnormal neural tube morpholog... 1 | 12
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal spine curvature 1 | 9
abnormal spleen morphology 1 | 55
abnormal tail movements 1 | 12
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased exploration in new e... 1 | 11
decreased heart rate variabili... 1 | 13
decreased pulmonary respirator... 1 | 5
decreased red blood cell distr... 1 | 41
enlarged lymph nodes 1 | 37
enlarged stomach 1 | 2
hemorrhage 1 | 23
hydrometra 1 | 53
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating amylase ... 1 | 25
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased hematocrit 1 | 46
increased mean corpuscular vol... 1 | 92
increased red blood cell distr... 1 | 34
limb grasping 1 | 41
long tibia 1 | 25
polycystic kidney 1 | 15
small testis 1 | 58
small thymus 1 | 16
thrombocytosis 1 | 27
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 149 | 11,493
osteosarcoma 117 | 7,950
ovarian cancer 98 | 8,520
psoriasis 80 | 6,694
glioblastoma 79 | 5,792
lung cancer 79 | 4,740
medulloblastoma, large-cell 70 | 6,241
interstitial cystitis 69 | 2,312
lung carcinoma 66 | 2,843
Cancer 64 | 2,499
atypical teratoid / rhabdoid tumor 60 | 5,112
ependymoma 56 | 4,679
malignant mesothelioma 56 | 3,232
Astrocytoma, Pilocytic 52 | 3,081
adult high grade glioma 52 | 3,801
lung adenocarcinoma 49 | 2,716
Breast cancer 48 | 3,578
non-small cell lung cancer 48 | 2,890
invasive ductal carcinoma 47 | 2,951
Kidney cancer 46 | 2,613
ulcerative colitis 45 | 1,819
intraductal papillary-mucinous carcinoma (IPMC) 44 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,291
pancreatic cancer 43 | 2,398
tuberculosis 41 | 2,010
subependymal giant cell astrocytoma 38 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,955
cutaneous lupus erythematosus 36 | 1,057
group 3 medulloblastoma 36 | 4,104
pituitary cancer 33 | 1,972
astrocytic glioma 32 | 2,597
primitive neuroectodermal tumor 32 | 3,035
cystic fibrosis 31 | 1,696
oligodendroglioma 30 | 2,850
Autosomal recessive predisposition 29 | 1,442
Rheumatoid arthritis 29 | 1,191
colon cancer 29 | 1,478
Schizophrenia 25 | 1,160
breast carcinoma 25 | 1,638
diabetes mellitus 25 | 1,728
Pick disease 24 | 1,894
ductal carcinoma in situ 23 | 1,745
acute quadriplegic myopathy 20 | 1,158
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,962
Hypersensitivity reaction type II disease 19 | 253
adrenocortical carcinoma 19 | 1,428
group 4 medulloblastoma 19 | 1,855
mucosa-associated lymphoid tissue lymphoma 19 | 484
Epilepsy 18 | 792
Multiple Sclerosis 18 | 540
primary Sjogren syndrome 18 | 735
Endometriosis 17 | 540
astrocytoma 17 | 1,146
Anemia 16 | 365
gastric carcinoma 16 | 807
pancreatic carcinoma 16 | 562
pediatric high grade glioma 16 | 1,064
primary pancreatic ductal adenocarcinoma 16 | 1,109
Autistic Disorder 15 | 364
Intellectual disability 15 | 1,016
Multiple myeloma 15 | 1,332
active Crohn's disease 15 | 922
juvenile dermatomyositis 15 | 1,187
Asthma 14 | 385
Liver cancer 14 | 604
Melanoma 14 | 711
Seizures 14 | 596
Alzheimer's disease 13 | 658
Cerebrovascular disease 13 | 238
Kidney disease 13 | 430
Obesity 13 | 678
dermatomyositis 13 | 966
spina bifida 13 | 1,074
Atherosclerosis 12 | 291
Liver Cirrhosis, Experimental 12 | 769
Malaria 12 | 160
sonic hedgehog group medulloblastoma 12 | 467
Bipolar Disorder 11 | 666
Coronary artery disease 11 | 268
Human immunodeficiency virus infectious disease 11 | 138
Hypertension 11 | 396
Inflammatory bowel disease 11 | 151
Liver disease 11 | 237
Thrombocytopenia 11 | 197
hepatocellular carcinoma 11 | 547
periodontitis 11 | 293
Arthritis 10 | 290
Depressive disorder 10 | 409
Duchenne muscular dystrophy 10 | 601
Inflammation 10 | 120
Skin cancer 10 | 469
esophageal adenocarcinoma 10 | 737
non primary Sjogren syndrome sicca 10 | 891
Hepatomegaly 9 | 285
Muscle hypotonia 9 | 571
Prostatic Neoplasms 9 | 495
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 510
fibroadenoma 9 | 559
gastric cancer 9 | 459
nasopharyngeal carcinoma 9 | 1,058

Tissue

Digestive Tract 196 | 17,369
Blood and immune system 195 | 16,909
Endocrine System 195 | 18,159
Female tissues 194 | 17,400
Male tissues 193 | 17,142
Skin and soft tissues 193 | 17,230
Urinary Tract 192 | 16,678
Liver and Pancreas 191 | 16,750
Respiratory system 190 | 16,393
Nervous System 184 | 16,725
Cardiovascular System 177 | 15,192

Target Family

Non-IDG 147 | 12,091
Enzyme 25 | 4,145
GPCR 15 | 408
Kinase 6 | 634
Transporter 4 | 473
Nuclear Receptor 2 | 48
oGPCR 2 | 421
Ion Channel 1 | 344

GO Function

receptor activity 202 | 202
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tumor necrosis factor receptor superfamily member 11A TNFRSF11A Tbio Non-IDG -3.26478 1689.0 464
Neurexin-1 NRXN1 Tbio Non-IDG -1.88807 125.1 174
E3 ubiquitin-protein ligase AMFR AMFR Tbio Enzyme -2.46909 292.8 203
Folate receptor alpha FOLR1 Tchem Non-IDG -2.33242 206.1 303
Small cell adhesion glycoprotein SMAGP Tdark Non-IDG -0.06695 1.95 82
Transportin-3 TNPO3 Tbio Non-IDG -1.74707 55.2 105
Derlin-1 DERL1 Tbio Non-IDG -1.88253 69.7 178
Cell surface A33 antigen GPA33 Tbio Non-IDG -1.79665 56.9 248
Neurexin-3 NRXN3 Tbio Non-IDG -1.34072 34.8 172
Retinal guanylyl cyclase 1 GUCY2D Tbio Kinase -2.20658 167.7 205