Development Level

Tbio 27 | 11,445
Tdark 7 | 6,588
Tchem 2 | 1,598

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal embryo size 1 | 220
abnormal sleep behavior 1 | 70
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased heart left ventricle... 1 | 28
decreased hemoglobin content 1 | 68
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
hypoactivity 1 | 132
impaired righting response 1 | 26
increased body length 1 | 32
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134

Disease

ovarian cancer 19 | 8,520
lung cancer 17 | 4,740
Carcinoma 14 | 11,493
osteosarcoma 11 | 7,950
psoriasis 10 | 6,694
glioblastoma 7 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
medulloblastoma, large-cell 7 | 6,241
atypical teratoid / rhabdoid tumor 6 | 5,112
group 3 medulloblastoma 6 | 4,104
Breast cancer 5 | 3,578
diabetes mellitus 5 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
malignant mesothelioma 5 | 3,232
non primary Sjogren syndrome sicca 5 | 891
Cancer 4 | 2,499
acute myeloid leukemia 4 | 783
adult high grade glioma 4 | 3,801
colon cancer 4 | 1,478
ependymoma 4 | 4,679
non-small cell lung cancer 4 | 2,890
pancreatic cancer 4 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
subependymal giant cell astrocytoma 4 | 2,287
Autosomal recessive predisposition 3 | 1,442
Breast Neoplasms 3 | 445
Mammary Neoplasms 3 | 425
Multiple myeloma 3 | 1,332
acute quadriplegic myopathy 3 | 1,158
breast carcinoma 3 | 1,638
cystic fibrosis 3 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
Acquired metabolic disease 2 | 336
Anemia 2 | 365
Astrocytoma, Pilocytic 2 | 3,081
Bowen-Conradi syndrome 2 | 16
Cognitive delay 2 | 608
Dull intelligence 2 | 645
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Global developmental delay 2 | 608
Hemoglobin low 2 | 124
Hepatomegaly 2 | 285
Intellectual disability 2 | 1,016
Large intestine cancer 2 | 126
Leukemia, Myelocytic, Acute 2 | 120
Liver Dysfunction 2 | 99
Low Birth Weights 2 | 69
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Pediatric failure to thrive 2 | 365
Poor school performance 2 | 645
Prostatic Neoplasms 2 | 495
Schizophrenia 2 | 1,160
Short stature 2 | 531
Small for gestational age (disorder) 2 | 69
Turner syndrome 2 | 28
Waldenstrons macroglobulinemia 2 | 765
adrenocortical carcinoma 2 | 1,428
dermatomyositis 2 | 966
hepatocellular carcinoma 2 | 547
inflammatory breast cancer 2 | 286
invasive ductal carcinoma 2 | 2,951
mucosa-associated lymphoid tissue lymphoma 2 | 484
non diabetic and post-ischemic heart failure 2 | 200
oligodendroglioma 2 | 2,850
pancreatic carcinoma 2 | 562
pediatric high grade glioma 2 | 1,064
primary Sjogren syndrome 2 | 735
primary pancreatic ductal adenocarcinoma 2 | 1,109
primitive neuroectodermal tumor 2 | 3,035
sonic hedgehog group medulloblastoma 2 | 467
spina bifida 2 | 1,074
ulcerative colitis 2 | 1,819
Abnormal urinary amino-acid findings 1 | 38
Acute Promyelocytic Leukemia 1 | 40
Aminoaciduria 1 | 38
Chromosome 2p16.1-p15 deletion syndrome 1 | 8
Exocrine pancreatic insufficiency 1 | 32
Gonadoblastoma 1 | 34
Gonorrhea 1 | 13
Hypomyelinating leukodystrophy 6 1 | 26
Increased calcium level in kidney 1 | 21
Increased intramyocellular lipid droplets 1 | 13
Leukemia, Acute Myeloid 1 | 17
Leukemia, Myeloid, Acute 1 | 105
Leukemia, Promyelocytic, Acute 1 | 36
Malignant neoplasm of prostate 1 | 11
Pain 1 | 103
Paralysed 1 | 42
Pseudoxanthoma elasticum 1 | 18
Recurrent infections 1 | 48
Sertoli cell-only syndrome 1 | 37
Short QT syndrome 1 | 12
Sickle Cell Anemia 1 | 53
Spermatogenic Failure, Nonobstructive, Y-Linked 1 | 15

Tissue

Blood and immune system 36 | 16,909
Endocrine System 36 | 18,159
Male tissues 36 | 17,142
Cardiovascular System 35 | 15,192
Digestive Tract 35 | 17,369
Female tissues 35 | 17,400
Liver and Pancreas 35 | 16,750
Nervous System 35 | 16,725
Respiratory system 35 | 16,393
Skin and soft tissues 35 | 17,230
Urinary Tract 35 | 16,678

Target Family

Non-IDG 26 | 12,091
Enzyme 8 | 4,145
Epigenetic 1 | 242
Kinase 1 | 634

GO Function

rRNA binding 36 | 36
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
39S ribosomal protein L11, mitochondrial MRPL11 Tdark Non-IDG -0.63555 3.41 198
Ribosome maturation protein SBDS SBDS Tbio Non-IDG -2.24233 174.4 139
39S ribosomal protein L20, mitochondrial MRPL20 Tdark Non-IDG 1.23 0.05 48
3'-5' exoribonuclease 1 ERI1 Tbio Enzyme -1.96395 87.8 172
Lysine-specific demethylase 2B KDM2B Tchem Epigenetic -1.56328 41.7 248
40S ribosomal protein S18 RPS18 Tbio Non-IDG -1.70681 45.8 128
60S ribosomal protein L12 RPL12 Tbio Non-IDG -1.85470 69.6 143
Ribosome production factor 2 homolog RPF2 Tbio Non-IDG -0.85431 7.55 124
Ribosomal RNA small subunit methyltransferase NEP1 EMG1 Tbio Enzyme 0.00000 119
Transcription termination factor 3, mitochondrial MTERF3 Tdark Non-IDG -1.11426 12.2 23