Development Level

Tbio 32 | 11,445
Tchem 13 | 1,598
Tdark 6 | 6,588
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
increased bone mineral content 2 | 108
abnormal behavior 1 | 298
abnormal glucose homeostasis 1 | 4
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal tail movements 1 | 12
brachydactyly 1 | 19
cataract 1 | 92
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased heart left ventricle... 1 | 28
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased prepulse inhibition 1 | 82
enlarged heart 1 | 210
hyperactivity 1 | 148
hypoactivity 1 | 132
increased circulating chloride... 1 | 41
increased circulating sodium l... 1 | 71
increased startle reflex 1 | 112
preweaning lethality, incomple... 1 | 499
syndactyly 1 | 23
thin ventricular wall 1 | 24

Disease

Carcinoma 34 | 11,493
ovarian cancer 28 | 8,520
psoriasis 25 | 6,694
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,962
medulloblastoma, large-cell 21 | 6,241
osteosarcoma 20 | 7,950
glioblastoma 17 | 5,792
group 3 medulloblastoma 17 | 4,104
adult high grade glioma 16 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
lung cancer 15 | 4,740
Autosomal recessive predisposition 14 | 1,442
atypical teratoid / rhabdoid tumor 14 | 5,112
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
Liver Cirrhosis, Experimental 12 | 769
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
invasive ductal carcinoma 12 | 2,951
tuberculosis 12 | 2,010
Astrocytoma, Pilocytic 11 | 3,081
non-small cell lung cancer 11 | 2,890
primitive neuroectodermal tumor 11 | 3,035
Schizophrenia 10 | 1,160
adrenocortical carcinoma 10 | 1,428
lung carcinoma 10 | 2,843
oligodendroglioma 10 | 2,850
Breast cancer 9 | 3,578
pituitary cancer 9 | 1,972
ductal carcinoma in situ 8 | 1,745
ependymoma 8 | 4,679
lung adenocarcinoma 8 | 2,716
malignant mesothelioma 8 | 3,232
Epilepsy 7 | 792
interstitial cystitis 7 | 2,312
pancreatic cancer 7 | 2,398
subependymal giant cell astrocytoma 7 | 2,287
Bipolar Disorder 6 | 666
Cancer 6 | 2,499
Intellectual disability 6 | 1,016
Major Depressive Disorder 6 | 301
Pick disease 6 | 1,894
Seizures 6 | 596
astrocytic glioma 6 | 2,597
breast carcinoma 6 | 1,638
group 4 medulloblastoma 6 | 1,855
Dull intelligence 5 | 645
Kidney cancer 5 | 2,613
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Multiple myeloma 5 | 1,332
Osteoporosis 5 | 363
Poor school performance 5 | 645
Unipolar Depression 5 | 250
colon cancer 5 | 1,478
cystic fibrosis 5 | 1,696
diabetes mellitus 5 | 1,728
nephrosclerosis 5 | 333
posterior fossa group A ependymoma 5 | 468
Alzheimer's disease 4 | 658
Atherosclerosis 4 | 291
Cognitive delay 4 | 608
Global developmental delay 4 | 608
Hyperreflexia 4 | 209
Mental and motor retardation 4 | 608
Metabolic acidosis 4 | 90
Neuropathy 4 | 261
astrocytoma 4 | 1,146
cutaneous lupus erythematosus 4 | 1,057
gastric carcinoma 4 | 807
non primary Sjogren syndrome sicca 4 | 891
Adenocarcinoma of lung 3 | 142
Anemia 3 | 365
Atopic dermatitis 3 | 952
Chemical and Drug Induced Liver Injury 3 | 195
Coronary artery disease 3 | 268
Depressive disorder 3 | 409
Disease Models, Animal 3 | 155
Down syndrome 3 | 499
Hyperhomocysteinemia 3 | 37
Hypertension 3 | 396
Hypoglycemia 3 | 152
Kidney disease 3 | 430
Malaria 3 | 160
Melanoma 3 | 711
Myoclonus 3 | 74
Primary hyperoxaluria 3 | 15
Succinic semialdehyde dehydrogenase deficiency 3 | 16
Waldenstrons macroglobulinemia 3 | 765
active ulcerative colitis 3 | 764
acute quadriplegic myopathy 3 | 1,158
aldosterone-producing adenoma 3 | 665
esophageal adenocarcinoma 3 | 737
facioscapulohumeral dystrophy 3 | 288
inflammatory breast cancer 3 | 286
mucosa-associated lymphoid tissue lymphoma 3 | 484
nasopharyngeal carcinoma 3 | 1,058
pediatric high grade glioma 3 | 1,064
posterior fossa group B ependymoma 3 | 416
primary pancreatic ductal adenocarcinoma 3 | 1,109
ulcerative colitis 3 | 1,819

Tissue

Digestive Tract 51 | 17,369
Liver and Pancreas 51 | 16,750
Skin and soft tissues 51 | 17,230
Endocrine System 50 | 18,159
Female tissues 50 | 17,400
Urinary Tract 50 | 16,678
Blood and immune system 48 | 16,909
Male tissues 48 | 17,142
Nervous System 48 | 16,725
Respiratory system 46 | 16,393
Cardiovascular System 42 | 15,192

Target Family

Enzyme 49 | 4,145
Non-IDG 3 | 12,091
Kinase 1 | 634

GO Function

pyridoxal phosphate binding 53 | 53
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 Tbio Enzyme -1.80580 61.7 153
Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 Tbio Enzyme -1.47858 32.0 77
Pyridoxine-5'-phosphate oxidase PNPO Tchem Enzyme -1.95803 90.7 200
1-aminocyclopropane-1-carboxylate synthase-like protein 1 ACCS Tbio Enzyme -2.31602 195.2 154
Cysteine desulfurase, mitochondrial NFS1 Tbio Enzyme -1.70267 46.3 131
Cysteine sulfinic acid decarboxylase CSAD Tbio Enzyme -2.16604 143.8 134
Threonine synthase-like 2 THNSL2 Tbio Enzyme -1.56098 37.5 97
Glycine dehydrogenase (decarboxylating), mitochondrial GLDC Tbio Enzyme -1.79392 65.7 131
Aspartate aminotransferase, mitochondrial GOT2 Tbio Enzyme -3.23630 1435.0 450
Glycogen phosphorylase, muscle form PYGM Tchem Enzyme -2.24324 158.2 208