Development Level

Tdark 7 | 6,593
Tbio 6 | 11,651

IMPC Phenotype

preweaning lethality, complete... 1 | 979

Disease

Carcinoma 9 | 11,493
ovarian cancer 7 | 8,520
lung cancer 5 | 4,740
medulloblastoma, large-cell 5 | 6,241
Dyskeratosis congenita 4 | 24
colon cancer 3 | 1,478
glioblastoma 3 | 5,792
group 3 medulloblastoma 3 | 4,104
malignant mesothelioma 3 | 3,232
psoriasis 3 | 6,694
Anemia 2 | 365
Breast cancer 2 | 3,578
Intellectual disability 2 | 1,016
Phenylketonuria 2 | 20
Pick disease 2 | 1,894
adult high grade glioma 2 | 3,801
astrocytic glioma 2 | 2,597
atypical teratoid / rhabdoid tumor 2 | 5,112
breast carcinoma 2 | 1,638
ependymoma 2 | 4,679
group 4 medulloblastoma 2 | 1,855
lung adenocarcinoma 2 | 2,716
non-small cell lung cancer 2 | 2,890
osteosarcoma 2 | 7,950
pancreatic cancer 2 | 2,398
pancreatic carcinoma 2 | 562
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
progressive supranuclear palsy 2 | 676
Abnormal blistering of the skin 1 | 54
Abnormality of female internal genitalia 1 | 13
Abnormality of the fingernails 1 | 51
Abnormality of the pharynx 1 | 19
Alopecia 1 | 115
Anorectal Malformations 1 | 8
Aplasia/Hypoplasia of the skin 1 | 16
Basal cell carcinoma 1 | 54
Blister of skin 1 | 54
Blood Coagulation Disorders 1 | 42
Bone marrow hypocellularity 1 | 20
Bowen-Conradi syndrome 1 | 16
Celiac disease 1 | 116
Cellular immunodeficiency 1 | 17
Coagulation abnormalities 1 | 27
Congestive heart failure 1 | 113
Conjunctivitis 1 | 53
Conjunctivitis, recurrent 1 | 37
Decreased platelet count 1 | 111
Dental caries 1 | 164
Dilated ventricles (finding) 1 | 121
Dystrophia unguium 1 | 53
Early tooth exfoliation 1 | 17
Esophageal Stenosis 1 | 15
Frequent fractures 1 | 53
Gastrointestinal system disease 1 | 54
Gingival Diseases 1 | 19
Hemorrhagic Disorders 1 | 30
Horseshoe Kidney 1 | 16
Hyperhidrosis disorder 1 | 81
Hyperpigmentation 1 | 37
Hyperpigmented macules 1 | 42
Hypodontia 1 | 81
Hypoplastic myelodysplasia 1 | 18
Hypoplastic-absent toenails 1 | 11
Immunologic Deficiency Syndromes 1 | 113
Increased fracture rate 1 | 53
Increased sweating 1 | 81
Large elongated pulp chamber 1 | 14
Leukemia, Myelocytic, Acute 1 | 120
Leukokeratosis 1 | 19
Leukopenia 1 | 72
Leukoplakia, Oral 1 | 20
MYELODYSPLASTIC SYNDROME 1 | 53
Malabsorption 1 | 82
Malignant Squamous Cell Neoplasm 1 | 17
Neutrophil abnormality 1 | 20
Nevoid basal cell carcinoma syndrome 1 | 16
Osteoporosis 1 | 363
Penile hypospadias 1 | 106
Periodontal Diseases 1 | 21
Premature tooth loss 1 | 17
Pulmonary Fibrosis 1 | 106
Recurrent respiratory infections 1 | 141
Ridged nails 1 | 14
Rotting teeth 1 | 73
Rough bone trabeculation 1 | 11
Skin Ulcer 1 | 48
Skin bulla 1 | 54
Small testicle 1 | 75
Sparse eyelashes 1 | 31
Sparse scalp hair 1 | 42
Squamous cell carcinoma 1 | 129
Sweating 1 | 81
Taurodontism 1 | 14
Telangiectasia of the skin 1 | 39
Thrombocytopenia 1 | 197
Tracheoesophageal Fistula 1 | 36
Urethral Stricture 1 | 18
Varying degree of multiple fractures 1 | 53
X- linked recessive 1 | 110
hypopigmented skin patch 1 | 59

Tissue

Blood and immune system 13 | 16,909
Cardiovascular System 13 | 15,192
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678

Target Family

Enzyme 12 | 4,145
Non-IDG 1 | 12,091

GO Function

pseudouridine synthase activit... 13 | 13
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..