Development Level

Tbio 16 | 11,445
Tdark 3 | 6,588
Tchem 2 | 1,598

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 4 | 278
abnormal kidney morphology 1 | 65
abnormal seminal vesicle morph... 1 | 114
cardiovascular system phenotyp... 1 | 36
decreased circulating bilirubi... 1 | 19
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
hypoactivity 1 | 132
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased or absent threshold ... 1 | 101
short tibia 1 | 97
small adrenal glands 1 | 16
small lymph nodes 1 | 1

Disease

Carcinoma 14 | 11,493
ovarian cancer 12 | 8,520
ependymoma 8 | 4,679
psoriasis 8 | 6,694
Pick disease 7 | 1,894
atypical teratoid / rhabdoid tumor 7 | 5,112
glioblastoma 7 | 5,792
medulloblastoma, large-cell 7 | 6,241
astrocytic glioma 6 | 2,597
lung carcinoma 6 | 2,843
oligodendroglioma 6 | 2,850
osteosarcoma 6 | 7,950
Multiple myeloma 5 | 1,332
primitive neuroectodermal tumor 5 | 3,035
Astrocytoma, Pilocytic 4 | 3,081
Cutis Laxa 4 | 39
Osteopetrosis 4 | 43
adult high grade glioma 4 | 3,801
group 3 medulloblastoma 4 | 4,104
Autosomal recessive predisposition 3 | 1,442
Breast cancer 3 | 3,578
Failure to gain weight 3 | 365
Pediatric failure to thrive 3 | 365
invasive ductal carcinoma 3 | 2,951
lung cancer 3 | 4,740
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 2,010
Anemia 2 | 365
Argentine hemorrhagic fever 2 | 10
Broad flat nasal bridge 2 | 236
Dental caries 2 | 164
Epilepsy 2 | 792
Frontal bossing 2 | 157
Gaucher disease type 1 2 | 180
Growth delay 2 | 114
Growth failure 2 | 114
Growth retardation 2 | 115
Hip joint varus deformity - observation 2 | 24
Kidney cancer 2 | 2,613
Late tooth eruption 2 | 61
Lymphoma, Follicular 2 | 18
Nasal bridge wide 2 | 236
Poor growth 2 | 114
Rotting teeth 2 | 73
Seizures 2 | 596
Short stature 2 | 531
Very poor growth 2 | 114
astrocytoma 2 | 1,146
breast carcinoma 2 | 1,638
chronic rhinosinusitis 2 | 512
cystic fibrosis 2 | 1,696
diabetes mellitus 2 | 1,728
hepatocellular carcinoma 2 | 547
medulloblastoma 2 | 720
pancreatic cancer 2 | 2,398
pediatric high grade glioma 2 | 1,064
ANONYCHIA 1 | 20
Acquired flat foot 1 | 72
Alkaline phosphatase serum increased 1 | 29
Bushy eyebrows 1 | 49
Calcinosis 1 | 70
Cystinuria 1 | 18
Decreased projection of midface 1 | 105
Decreased size of teeth 1 | 62
Decreased width of tooth 1 | 59
Deep philtrum 1 | 21
Dehydration 1 | 40
Depressed philtrum 1 | 21
Enlarged vestibular aqueduct 1 | 10
Flatfoot 1 | 73
Fragile nails 1 | 16
Hereditary elliptocytosis 1 | 22
Histoplasmosis 1 | 13
Hyperkyphosis 1 | 111
Hypokalemia 1 | 52
Hypokalemic periodic paralysis 1 | 11
Hypotrophic midface 1 | 105
Imperforate anus 1 | 25
Increased calcium level in kidney 1 | 21
Infection of bone 1 | 19
Kyphosis deformity of spine 1 | 114
Lipodystrophy 1 | 40
Metabolic acidosis 1 | 90
Microdontia (disorder) 1 | 59
Micronychia (disorder) 1 | 24
Midface retrusion 1 | 105
Ophthalmoparesis 1 | 11
Osteopetrosis autosomal recessive 1 1 | 2
Osteopetrosis, Autosomal Recessive 1 1 | 2
Ovarian Cysts 1 | 41
Pathological fracture 1 | 20
Pigmented villonodular synovitis 1 | 9
Precancerous Conditions 1 | 80
Progressive microcephaly 1 | 32
RENAL TUBULAR ACIDOSIS, DISTAL, AUTOSOMAL RECESSIVE 1 | 3
Sensorineural hearing loss, bilateral 1 | 18
Sickle Cell Anemia 1 | 53
Small midface 1 | 105
Tetany 1 | 18
Thick vermilion border 1 | 25

Tissue

Blood and immune system 21 | 16,909
Digestive Tract 21 | 17,369
Endocrine System 21 | 18,159
Female tissues 21 | 17,400
Male tissues 21 | 17,142
Nervous System 21 | 16,725
Respiratory system 21 | 16,393
Skin and soft tissues 21 | 17,230
Urinary Tract 21 | 16,678
Cardiovascular System 20 | 15,192
Liver and Pancreas 20 | 16,750

Target Family

Enzyme 21 | 4,145

GO Function

proton-transporting ATPase act... 21 | 21
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V-type proton ATPase 116 kDa subunit a isoform 4 ATP6V0A4 Tbio Enzyme -2.84949 692.2 90
V-type proton ATPase subunit E 1 ATP6V1E1 Tbio Enzyme -1.04091 10.7 137
V-type proton ATPase catalytic subunit A ATP6V1A Tbio Enzyme -1.83801 66.4 144
V-type proton ATPase subunit E 2 ATP6V1E2 Tbio Enzyme -0.78312 6.53 60
V-type proton ATPase subunit F ATP6V1F Tbio Enzyme -0.91914 8.76 118
V-type proton ATPase subunit C 1 ATP6V1C1 Tbio Enzyme -1.31659 21.7 102
V-type proton ATPase subunit B, brain isoform ATP6V1B2 Tchem Enzyme -1.39933 24.1 157
V-type proton ATPase subunit S1-like protein ATP6AP1L Tdark Enzyme 0.30 0.50 21
V-type proton ATPase 21 kDa proteolipid subunit ATP6V0B Tbio Enzyme -0.96261 10.7 81
V-type proton ATPase subunit S1 ATP6AP1 Tchem Enzyme -1.94689 91.3 166