Development Level

Tbio 60 | 11,178
Tchem 23 | 1,885
Tdark 8 | 6,569

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 5 | 499
increased lean body mass 4 | 172
abnormal embryo size 3 | 220
decreased total body fat amoun... 3 | 207
edema 3 | 59
abnormal bone structure 2 | 187
abnormal sleep behavior 2 | 70
decreased lean body mass 2 | 135
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
male infertility 2 | 123
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal humerus morphology 1 | 11
abnormal locomotor behavior 1 | 24
abnormal pericardium morpholog... 1 | 26
abnormal testis morphology 1 | 43
brachydactyly 1 | 19
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating magnesiu... 1 | 13
decreased circulating potassiu... 1 | 20
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased cornea thickness 1 | 2
decreased grip strength 1 | 116
decreased total retina thickne... 1 | 17
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged uterus 1 | 11
female infertility 1 | 60
hydrometra 1 | 53
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
increased vertical activity 1 | 24
limb grasping 1 | 41
persistence of hyaloid vascula... 1 | 33
prolonged ST segment 1 | 36
small adrenal glands 1 | 16
small kidney 1 | 16
small superior vagus ganglion 1 | 74
small testis 1 | 58
syndactyly 1 | 23

Disease

Carcinoma 67 | 11,192
osteosarcoma 42 | 7,766
ovarian cancer 42 | 8,297
medulloblastoma, large-cell 38 | 6,086
glioblastoma 36 | 5,635
psoriasis 33 | 6,514
ependymoma 32 | 4,559
lung cancer 31 | 4,607
atypical teratoid / rhabdoid tumor 28 | 4,971
group 3 medulloblastoma 24 | 4,002
malignant mesothelioma 24 | 3,135
Kidney cancer 22 | 2,548
adult high grade glioma 22 | 3,701
non-small cell lung cancer 21 | 2,799
oligodendroglioma 21 | 2,768
Breast cancer 20 | 3,469
astrocytic glioma 20 | 2,530
interstitial cystitis 20 | 2,237
ulcerative colitis 20 | 1,765
primitive neuroectodermal tumor 18 | 2,957
group 4 medulloblastoma 17 | 1,806
Astrocytoma, Pilocytic 15 | 3,006
Pick disease 15 | 1,856
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,204
Cancer 14 | 2,388
invasive ductal carcinoma 14 | 2,867
lung carcinoma 14 | 2,755
breast carcinoma 13 | 1,589
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,902
lung adenocarcinoma 13 | 2,627
pituitary cancer 13 | 1,915
colon cancer 12 | 1,428
subependymal giant cell astrocytoma 12 | 2,230
tuberculosis 12 | 1,963
acute quadriplegic myopathy 11 | 1,133
Schizophrenia 10 | 1,136
cystic fibrosis 10 | 1,629
pancreatic cancer 10 | 2,322
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,911
spina bifida 10 | 1,053
adrenocortical carcinoma 9 | 1,385
cutaneous lupus erythematosus 9 | 1,016
dermatomyositis 9 | 941
diabetes mellitus 9 | 1,683
ductal carcinoma in situ 9 | 1,686
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,872
non primary Sjogren syndrome sicca 9 | 861
pediatric high grade glioma 9 | 1,035
Autosomal recessive predisposition 8 | 1,407
Liver Cirrhosis, Experimental 8 | 733
esophageal adenocarcinoma 8 | 696
juvenile dermatomyositis 8 | 1,147
Centronuclear myopathy 7 | 27
Melanoma 7 | 689
Rheumatoid arthritis 7 | 1,156
Skin cancer 7 | 451
aldosterone-producing adenoma 7 | 646
astrocytoma 7 | 1,113
progressive supranuclear palsy 7 | 656
Chronic Lymphocytic Leukemia 6 | 254
Duchenne muscular dystrophy 6 | 587
active Crohn's disease 6 | 882
gastric carcinoma 6 | 781
Acquired metabolic disease 5 | 329
Acquired scoliosis 5 | 274
Byzanthine arch palate 5 | 194
Crohn's disease 5 | 311
Curvature of spine 5 | 275
Endometriosis 5 | 521
Liver cancer 5 | 589
Multiple myeloma 5 | 1,296
Nonsyndromic deafness 5 | 137
medulloblastoma 5 | 702
urothelial carcinoma 5 | 303
Amyotrophic lateral sclerosis 4 | 437
Atopic dermatitis 4 | 915
Endometrial cancer 4 | 301
Epilepsy 4 | 775
Lymphoid leukemia 4 | 156
Obesity 4 | 655
Sensorineural Hearing Loss (disorder) 4 | 281
Short stature 4 | 514
Waldenstrons macroglobulinemia 4 | 742
active ulcerative colitis 4 | 736
gastric cancer 4 | 445
hepatocellular carcinoma 4 | 536
nasopharyngeal carcinoma 4 | 1,024
primary Sjogren syndrome 4 | 710
primary pancreatic ductal adenocarcinoma 4 | 1,071
Alzheimer's disease 3 | 640
Arthritis, Rheumatoid 3 | 169
Bipolar Disorder 3 | 646
Depressive disorder 3 | 401
Mental Depression 3 | 325
acute myeloid leukemia 3 | 760
chronic rhinosinusitis 3 | 505
fibroadenoma 3 | 538
mucosa-associated lymphoid tissue lymphoma 3 | 473
pancreatic carcinoma 3 | 555
sonic hedgehog group medulloblastoma 3 | 459

Tissue

Endocrine System 89 | 18,159
Blood and immune system 88 | 16,909
Digestive Tract 88 | 17,369
Female tissues 88 | 17,400
Male tissues 87 | 17,142
Nervous System 86 | 16,725
Skin and soft tissues 86 | 17,230
Cardiovascular System 84 | 15,192
Liver and Pancreas 84 | 16,750
Urinary Tract 84 | 16,678
Respiratory system 83 | 16,393

Target Family

Enzyme 84 | 4,145
Non-IDG 7 | 12,091

GO Function

protein tyrosine phosphatase a... 91 | 91
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 5 DUSP5 Tbio Enzyme -2.50738 309.0 198
Dual specificity protein phosphatase 2 DUSP2 Tbio Enzyme -1.30606 18.7 63
Laforin EPM2A Tbio Enzyme -2.18932 282.5 394
Ubiquitin-associated and SH3 domain-containing protein B UBASH3B Tbio Non-IDG -1.67701 48.9 95
Tyrosine-protein phosphatase non-receptor type 20 PTPN20 Tdark Enzyme -0.12494 1.72 59
Eyes absent homolog 3 EYA3 Tbio Non-IDG -0.93756 7.66 93
Dual specificity protein phosphatase 8 DUSP8 Tbio Enzyme -1.85247 65.9 169
Tyrosine-protein phosphatase non-receptor type 21 PTPN21 Tbio Enzyme -0.78688 8.67 92
Receptor-type tyrosine-protein phosphatase O PTPRO Tbio Enzyme -1.70513 58.0 56
Dual specificity protein phosphatase 6 DUSP6 Tbio Enzyme -2.22889 183.5 379