Development Level

Tchem 51 | 1,598
Tclin 36 | 613
Tbio 35 | 11,445

Collection

Kinase: IDG Consortium (Target... 11 | 125
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 13 | 979
embryonic lethality prior to t... 5 | 278
abnormal bone structure 4 | 187
abnormal embryo size 4 | 220
abnormal retinal vasculature m... 3 | 27
cataract 3 | 92
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
decreased leukocyte cell numbe... 3 | 73
abnormal gait 2 | 69
abnormal lens morphology 2 | 81
abnormal retinal blood vessel ... 2 | 26
abnormal seminal vesicle morph... 2 | 114
decreased large unstained cell... 2 | 11
decreased lean body mass 2 | 135
embryonic lethality prior to o... 2 | 239
enlarged heart 2 | 210
impaired pupillary reflex 2 | 26
increased circulating choleste... 2 | 66
increased total body fat amoun... 2 | 134
male infertility 2 | 123
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal body wall morphology 1 | 9
abnormal cornea morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal hair growth 1 | 10
abnormal maxilla morphology 1 | 17
abnormal optic disc morphology 1 | 10
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal snout morphology 1 | 23
abnormal tail morphology 1 | 25
abnormal testis morphology 1 | 43
abnormal urinary bladder morph... 1 | 11
absent startle reflex 1 | 24
cleft palate 1 | 8
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged lymph nodes 1 | 37
female infertility 1 | 60
fused cornea and lens 1 | 5
hemorrhage 1 | 23
impaired righting response 1 | 26
increased CD4-positive, alpha ... 1 | 4
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased grip strength 1 | 41
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
increased startle reflex 1 | 112
iris synechia 1 | 3
limb grasping 1 | 41
narrow eye opening 1 | 12
no spontaneous movement 1 | 1
persistence of hyaloid vascula... 1 | 33
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

Carcinoma 98 | 11,493
Cancer 81 | 2,499
osteosarcoma 71 | 7,950
ovarian cancer 68 | 8,520
lung cancer 52 | 4,740
medulloblastoma, large-cell 50 | 6,241
psoriasis 50 | 6,694
glioblastoma 46 | 5,792
Breast cancer 44 | 3,578
Kidney cancer 39 | 2,613
atypical teratoid / rhabdoid tumor 38 | 5,112
non-small cell lung cancer 37 | 2,890
ependymoma 35 | 4,679
interstitial cystitis 35 | 2,312
malignant mesothelioma 35 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 33 | 3,291
group 3 medulloblastoma 29 | 4,104
invasive ductal carcinoma 29 | 2,951
Autosomal recessive predisposition 26 | 1,442
lung adenocarcinoma 26 | 2,716
lung carcinoma 26 | 2,843
Astrocytoma, Pilocytic 25 | 3,081
adult high grade glioma 25 | 3,801
oligodendroglioma 25 | 2,850
tuberculosis 25 | 2,010
ulcerative colitis 25 | 1,819
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,989
subependymal giant cell astrocytoma 23 | 2,287
pancreatic cancer 22 | 2,398
primitive neuroectodermal tumor 22 | 3,035
Blastic phase chronic myeloid leukemia 21 | 58
Chronic Myelocytic Leukemia Accelerated Phase 21 | 59
Schizophrenia 21 | 1,160
Philadelphia chromosome-positive acute lymphoblastic leukemia 20 | 47
diabetes mellitus 20 | 1,728
Breast Neoplasms 19 | 445
Chronic phase chronic myeloid leukemia 19 | 45
Mammary Neoplasms 19 | 425
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 19 | 45
cutaneous lupus erythematosus 19 | 1,057
cystic fibrosis 19 | 1,696
group 4 medulloblastoma 19 | 1,855
astrocytic glioma 17 | 2,597
ductal carcinoma in situ 17 | 1,745
pituitary cancer 17 | 1,972
Melanoma 16 | 711
Rheumatoid arthritis 16 | 1,191
colon cancer 16 | 1,478
Down syndrome 15 | 499
Pick disease 15 | 1,894
Renal Cell Carcinoma 15 | 214
astrocytoma 15 | 1,146
Intellectual disability 14 | 1,016
Skin cancer 14 | 469
breast carcinoma 14 | 1,638
Bipolar Disorder 12 | 666
Cleft Palate 12 | 271
Depressive disorder 12 | 409
Liver Cirrhosis, Experimental 12 | 769
Multiple myeloma 12 | 1,332
adrenocortical carcinoma 12 | 1,428
Dull intelligence 11 | 645
Liver cancer 11 | 604
Low intelligence 11 | 645
Lung Neoplasms 11 | 232
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
Short stature 11 | 531
Vascular disease 11 | 319
dermatomyositis 11 | 966
Alzheimer's disease 10 | 658
Cryptorchidism 10 | 296
Diarrhea 10 | 253
Hamman-Rich syndrome 10 | 34
Hypereosinophilic syndrome 10 | 71
Major Depressive Disorder 10 | 301
Orbital separation excessive 10 | 244
Unipolar Depression 10 | 250
non-small cell lung carcinoma 10 | 317
primary pancreatic ductal adenocarcinoma 10 | 1,109
spina bifida 10 | 1,074
Carcinoma, Hepatocellular 9 | 228
Cleft Lip 9 | 141
Cognitive delay 9 | 608
Global developmental delay 9 | 608
Hypoplastic mandible condyle 9 | 275
Immune system cancer 9 | 140
Liver carcinoma 9 | 240
Mandibular hypoplasia 9 | 275
Mental and motor retardation 9 | 608
Micrognathism 9 | 275
Neoplasm Invasiveness 9 | 161
Prostatic Neoplasms 9 | 495
Stomach Neoplasms 9 | 300
Waldenstrons macroglobulinemia 9 | 765
gastric carcinoma 9 | 807
non primary Sjogren syndrome sicca 9 | 891
primary Sjogren syndrome 9 | 735

Tissue

Endocrine System 121 | 18,159
Digestive Tract 119 | 17,369
Male tissues 119 | 17,142
Female tissues 118 | 17,400
Skin and soft tissues 118 | 17,230
Urinary Tract 118 | 16,678
Blood and immune system 117 | 16,909
Nervous System 117 | 16,725
Liver and Pancreas 116 | 16,750
Respiratory system 116 | 16,393
Cardiovascular System 110 | 15,192

Target Family

Kinase 78 | 634
Non-IDG 39 | 12,091
Epigenetic 2 | 242
Transcription Factor 2 | 1,400
Enzyme 1 | 4,145

GO Function

protein tyrosine kinase activi... 122 | 122
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase Fer FER Tchem Kinase -1.86307 55.4 414
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092
Dual specificity tyrosine-phosphorylation-regulated kinase 1A DYRK1A Tchem Kinase -2.68760 506.6 336
Pro-neuregulin-4, membrane-bound isoform NRG4 Tbio Non-IDG -1.33564 24.6 137
Tyrosine-protein kinase BAZ1B BAZ1B Tbio Epigenetic -1.45627 32.0 155
Dual specificity tyrosine-phosphorylation-regulated kinase 1B DYRK1B Tchem Kinase -1.63295 52.7 289
Abelson tyrosine-protein kinase 2 ABL2 Tchem Kinase -1.86293 71.2 358
Tyrosine-protein kinase FRK FRK Tchem Kinase -1.68365 49.2 394
Megakaryocyte-associated tyrosine-protein kinase MATK Tbio Kinase -2.98596 792.3 265
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448