Development Level

Tbio 49 | 10,625
Tdark 11 | 7,003
Tchem 4 | 1,890
Tclin 3 | 602

IMPC Term

preweaning lethality, complete... 3 | 633
decreased circulating fructosa... 2 | 31
decreased grip strength 2 | 123
increased circulating alkaline... 2 | 119
straub tail 2 | 26
abnormal lens morphology 1 | 73
abnormal seminal vesicle morph... 1 | 47
absent pinna reflex 1 | 21
decreased body weight 1 | 174
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating creatini... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating iron lev... 1 | 25
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased lactate dehydrogenas... 1 | 14
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular vol... 1 | 50
embryonic lethality prior to t... 1 | 187
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating aspartat... 1 | 17
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating triglyce... 1 | 24
increased fasted circulating g... 1 | 68
increased heart rate 1 | 17
increased hematocrit 1 | 36
increased or absent threshold ... 1 | 128
increased rib number 1 | 41
increased sacral vertebrae num... 1 | 62

Disease

ovarian cancer 46 | 8,484
osteosarcoma 36 | 7,933
psoriasis 26 | 6,685
medulloblastoma, large-cell 24 | 6,234
glioblastoma 21 | 5,572
lung cancer 20 | 4,466
atypical teratoid / rhabdoid tumor 17 | 4,369
Pick disease 13 | 1,893
lung adenocarcinoma 12 | 2,713
oligodendroglioma 12 | 2,849
ependymoma 11 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,988
Breast cancer 10 | 3,094
astrocytic glioma 10 | 2,241
dermatomyositis 10 | 933
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,289
medulloblastoma 10 | 1,524
Multiple myeloma 9 | 1,327
adult high grade glioma 9 | 2,148
group 4 medulloblastoma 9 | 1,875
malignant mesothelioma 9 | 3,162
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
pediatric high grade glioma 9 | 2,712
primitive neuroectodermal tumor 9 | 3,031
astrocytoma 8 | 1,493
invasive ductal carcinoma 8 | 2,950
Waldenstrons macroglobulinemia 7 | 765
diabetes mellitus 7 | 1,663
subependymal giant cell astrocytoma 7 | 2,287
ulcerative colitis 7 | 2,087
group 3 medulloblastoma 6 | 2,254
hereditary spastic paraplegia 6 | 313
interstitial cystitis 6 | 2,299
pancreatic cancer 6 | 2,300
posterior fossa group B ependymoma 6 | 1,530
tuberculosis 6 | 1,557
Hypertension 5 | 287
non-small cell lung cancer 5 | 2,798
primary pancreatic ductal adenocarcinoma 5 | 1,271
Alzheimer's disease 4 | 644
Carcinoma 4 | 2,147
Intellectual disability 4 | 573
Type 1 Diabetes Mellitus Treatment Adjunct 4 | 4
Type 2 Diabetes Mellitus Treatment Adjunct 4 | 7
acute myeloid leukemia 4 | 780
acute quadriplegic myopathy 4 | 1,157
adrenocortical carcinoma 4 | 1,427
breast carcinoma 4 | 1,614
colon cancer 4 | 1,475
lung carcinoma 4 | 2,844
spina bifida 4 | 1,064
Cancer 3 | 2,346
Neurodegenerative disease 3 | 383
Polycystic Ovary Syndrome 3 | 332
Rheumatoid Arthritis 3 | 1,160
Schizophrenia 3 | 501
Type 2 diabetes mellitus 3 | 189
aldosterone-producing adenoma 3 | 664
atypical teratoid/rhabdoid tumor 3 | 1,095
cystic fibrosis 3 | 1,665
non primary Sjogren syndrome sicca 3 | 840
non-small cell lung carcinoma 3 | 413
pancreatic carcinoma 3 | 567
pilocytic astrocytoma 3 | 3,086
progressive supranuclear palsy 3 | 674
sonic hedgehog group medulloblastoma 3 | 1,482
Amyotrophic Lateral Sclerosis 2 | 431
Atopic dermatitis 2 | 944
Barth syndrome 2 | 23
Becker muscular dystrophy 2 | 187
Cerebral palsy 2 | 28
Crohn's disease 2 | 304
Diabetes Mellitus, Non-Insulin-Dependent 2 | 157
HIV Infections 2 | 100
Heart disease 2 | 279
IGA Glomerulonephritis 2 | 454
Kidney disease 2 | 396
Lennox-Gastaut syndrome 2 | 34
Microcephaly 2 | 149
Migraine 2 | 79
Osteoporosis 2 | 257
Paraplegia 2 | 71
Parkinson's disease 2 | 364
Quadriplegia 2 | 14
Weight Gain 2 | 87
Wolff-Parkinson-White syndrome 2 | 11
X-linked cerebral adrenoleukodystrophy 2 | 115
active ulcerative colitis 2 | 477
cutaneous lupus erythematosus 2 | 1,056
ductal carcinoma in situ 2 | 1,745
esophageal adenocarcinoma 2 | 737
gastric cancer 2 | 430
gastric carcinoma 2 | 832
head and neck cancer and chronic obstructive pulmonary disease 2 | 237
hepatocellular carcinoma 2 | 532
juvenile dermatomyositis 2 | 1,189
systemic lupus erythematosus 2 | 156
tuberculosis and treatment for 3 months 2 | 327
tuberculosis and treatment for 6 months 2 | 686

Tissue

Blood and immune system 67 | 17,995
Cardiovascular System 67 | 17,958
Digestive Tract 67 | 18,473
Endocrine System 67 | 18,512
Female tissues 67 | 18,647
Liver and Pancreas 67 | 18,136
Male tissues 67 | 17,969
Nervous System 67 | 18,561
Respiratory system 67 | 17,484
Skin and soft tissues 67 | 18,115
Urinary Tract 67 | 18,444

Target Family

Non-IDG 58 | 11,971
Enzyme 6 | 4,146
GPCR 2 | 406
Ion Channel 1 | 341

GO Function

protein transporter activity 67 | 67
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein transport protein Sec61 subunit gamma SEC61G Tdark Non-IDG -0.37727 2.21 27
Ras-related protein Rap-1A RAP1A Tchem Enzyme -2.40521 288.3 256
Protein Hikeshi HIKESHI Tbio Non-IDG -1.00504 12.4 101
AP-1 complex subunit beta-1 AP1B1 Tbio Non-IDG -1.51499 33.3 58
AP-2 complex subunit alpha-2 AP2A2 Tbio Non-IDG -0.63932 4.63 109
Calcitonin receptor CALCR Tclin GPCR -2.52609 315.1 0
Importin subunit alpha-6 KPNA5 Tbio Non-IDG -0.87241 7.28 161
AP-1 complex subunit gamma-1 AP1G1 Tbio Non-IDG -1.47982 30.4 158
Vacuolar protein sorting-associated protein 35 VPS35 Tchem Non-IDG -1.95928 98.3 116
AP-4 complex subunit sigma-1 AP4S1 Tdark Non-IDG -0.58760 4.76 18