Development Level

Tbio 55 | 11,651
Tdark 8 | 6,593
Tclin 4 | 612
Tchem 2 | 1,388

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 3 | 499
abnormal seminal vesicle morph... 2 | 114
decreased grip strength 2 | 116
abnormal behavior 1 | 298
abnormal cecum morphology 1 | 7
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal heart shape 1 | 5
abnormal retinal blood vessel ... 1 | 26
abnormal skin coloration 1 | 25
abnormal urinary bladder morph... 1 | 11
absent pinna reflex 1 | 23
decreased body weight 1 | 161
decreased circulating aspartat... 1 | 34
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating sodium l... 1 | 22
decreased lactate dehydrogenas... 1 | 16
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to t... 1 | 278
enlarged cecum 1 | 5
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
hydrometra 1 | 53
increased body temperature 1 | 9
increased circulating aspartat... 1 | 15
increased circulating free fat... 1 | 20
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased or absent threshold ... 1 | 101
pallor 1 | 34
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

ovarian cancer 47 | 8,520
Carcinoma 45 | 11,493
osteosarcoma 37 | 7,950
psoriasis 26 | 6,694
medulloblastoma, large-cell 25 | 6,241
glioblastoma 23 | 5,792
lung cancer 22 | 4,740
atypical teratoid / rhabdoid tumor 20 | 5,112
ependymoma 16 | 4,679
Pick disease 14 | 1,894
adult high grade glioma 14 | 3,801
group 4 medulloblastoma 13 | 1,855
lung adenocarcinoma 13 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
oligodendroglioma 12 | 2,850
astrocytic glioma 11 | 2,597
group 3 medulloblastoma 11 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Breast cancer 10 | 3,578
Multiple myeloma 10 | 1,332
dermatomyositis 10 | 966
invasive ductal carcinoma 9 | 2,951
malignant mesothelioma 9 | 3,232
primitive neuroectodermal tumor 9 | 3,035
non-small cell lung cancer 8 | 2,890
tuberculosis 8 | 2,010
Kidney cancer 7 | 2,613
Waldenstrons macroglobulinemia 7 | 765
astrocytoma 7 | 1,146
diabetes mellitus 7 | 1,728
pancreatic cancer 7 | 2,398
subependymal giant cell astrocytoma 7 | 2,287
ulcerative colitis 7 | 1,819
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
Schizophrenia 6 | 1,160
hereditary spastic paraplegia 6 | 318
interstitial cystitis 6 | 2,312
Adenocarcinoma of lung 5 | 142
Autosomal recessive predisposition 5 | 1,442
Disease Models, Animal 5 | 155
Hypertension 5 | 396
Intellectual disability 5 | 1,016
acute quadriplegic myopathy 5 | 1,158
pediatric high grade glioma 5 | 1,064
Cancer 4 | 2,499
Dystonia 4 | 164
Liver Cirrhosis, Experimental 4 | 769
Muscle hypotonia 4 | 571
Prenatal onset 4 | 139
Type 1 Diabetes Mellitus Treatment Adjunct 4 | 4
Type 2 Diabetes Mellitus Treatment Adjunct 4 | 7
acute myeloid leukemia 4 | 783
adrenocortical carcinoma 4 | 1,428
breast carcinoma 4 | 1,638
colon cancer 4 | 1,478
lung carcinoma 4 | 2,843
medulloblastoma 4 | 720
primary pancreatic ductal adenocarcinoma 4 | 1,109
spina bifida 4 | 1,074
Astrocytoma, Pilocytic 3 | 3,081
Coarse facial features 3 | 108
Deafness dystonia syndrome 3 | 21
Dilated ventricles (finding) 3 | 121
Neurodegenerative disease 3 | 414
Polycystic ovary syndrome 3 | 360
Rheumatoid arthritis 3 | 1,191
Severe mental retardation (I.Q. 20-34) 3 | 99
Small head 3 | 374
Thickened facial skin with coarse facial features 3 | 108
Type 2 diabetes mellitus 3 | 272
aldosterone-producing adenoma 3 | 665
cystic fibrosis 3 | 1,696
non primary Sjogren syndrome sicca 3 | 891
pancreatic carcinoma 3 | 562
progressive supranuclear palsy 3 | 676
Acquired scoliosis 2 | 281
Alzheimer's disease 2 | 658
Atopic dermatitis 2 | 952
Byzanthine arch palate 2 | 194
Curvature of spine 2 | 282
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Epilepsy 2 | 792
Heart disease 2 | 306
Hepatomegaly 2 | 285
Kidney disease 2 | 430
Major Depressive Disorder 2 | 301
Paraplegia 2 | 74
Parkinson's disease 2 | 392
Seizures 2 | 596
Strabismus 2 | 270
active ulcerative colitis 2 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
esophageal adenocarcinoma 2 | 737
hepatocellular carcinoma 2 | 547
posterior fossa group B ependymoma 2 | 416

Tissue

Digestive Tract 69 | 17,369
Female tissues 69 | 17,400
Liver and Pancreas 69 | 16,750
Respiratory system 69 | 16,393
Cardiovascular System 68 | 15,192
Endocrine System 68 | 18,159
Male tissues 68 | 17,142
Nervous System 68 | 16,725
Skin and soft tissues 68 | 17,230
Urinary Tract 68 | 16,678
Blood and immune system 67 | 16,909

Target Family

Non-IDG 59 | 12,091
Enzyme 7 | 4,145
GPCR 2 | 408
Ion Channel 1 | 344

GO Function

protein transporter activity 69 | 69
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Eukaryotic translation initiation factor 4E transporter EIF4ENIF1 Tbio Non-IDG -1.60874 36.7 242
AP-4 complex subunit sigma-1 AP4S1 Tdark Non-IDG -0.68049 4.42 25
AP-4 complex subunit beta-1 AP4B1 Tbio Non-IDG -0.79214 6.23 124
Vacuolar protein sorting-associated protein 35 VPS35 Tbio Non-IDG -2.02621 104.1 124
Importin subunit beta-1 KPNB1 Tbio Non-IDG -1.63038 38.8 174
Importin subunit alpha-1 KPNA2 Tbio Non-IDG -1.90187 84.5 281
Importin subunit alpha-5 KPNA1 Tbio Non-IDG -1.95092 85.3 284
RUN and FYVE domain-containing protein 1 RUFY1 Tbio Non-IDG -0.58196 5.60 145
AP-2 complex subunit sigma AP2S1 Tbio Non-IDG -1.42073 25.5 108
AP-2 complex subunit beta AP2B1 Tbio Non-IDG -1.59767 34.8 212