Development Level

Tbio 6 | 11,445

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
absent startle reflex 1 | 24
cataract 1 | 92
hyperactivity 1 | 148
increased total body fat amoun... 1 | 134

Disease

Breast cancer 3 | 3,578
lung cancer 3 | 4,740
osteosarcoma 3 | 7,950
Carcinoma 2 | 11,493
Multiple myeloma 2 | 1,332
atypical teratoid / rhabdoid tumor 2 | 5,112
ependymoma 2 | 4,679
fibroadenoma 2 | 559
glioblastoma 2 | 5,792
group 3 medulloblastoma 2 | 4,104
lung adenocarcinoma 2 | 2,716
non-small cell lung cancer 2 | 2,890
psoriasis 2 | 6,694
Adenocarcinoma 1 | 122
Adenocarcinoma of lung 1 | 142
Alzheimer's disease 1 | 658
Astrocytoma, Pilocytic 1 | 3,081
Cancer 1 | 2,499
Cardiovascular system disease 1 | 246
Chylomicron retention disease 1 | 11
Cognitive disorder 1 | 50
Disease Models, Animal 1 | 155
Endometrial cancer 1 | 311
Familial hyperlipidemia 1 | 6
HYPERLIPOPROTEINEMIA, TYPE ID 1 | 1
Hypervitaminosis A 1 | 13
Lung Neoplasms 1 | 232
Macular degeneration 1 | 65
Major Depressive Disorder 1 | 301
Metabolic syndrome X 1 | 52
Nonorganic psychosis 1 | 84
Obesity 1 | 678
Pancreatitis 1 | 123
Polycystic ovary syndrome 1 | 360
Prostatic Neoplasms 1 | 495
Psychotic Disorders 1 | 151
Sinusitis 1 | 65
Spinocerebellar ataxia type 12 1 | 5
Unipolar Depression 1 | 250
active ulcerative colitis 1 | 764
adult high grade glioma 1 | 3,801
atypical teratoid/rhabdoid tumor 1 | 357
breast carcinoma 1 | 1,638
chronic rhinosinusitis 1 | 512
cystic fibrosis 1 | 1,696
diabetes mellitus 1 | 1,728
ductal carcinoma in situ 1 | 1,745
interstitial cystitis 1 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 1 | 3,291
invasive ductal carcinoma 1 | 2,951
lung carcinoma 1 | 2,843
malignant mesothelioma 1 | 3,232
medulloblastoma, large-cell 1 | 6,241
nephrosclerosis 1 | 333
non primary Sjogren syndrome sicca 1 | 891
ovarian cancer 1 | 8,520
pancreatic cancer 1 | 2,398
pediatric high grade glioma 1 | 1,064
pituitary cancer 1 | 1,972
primary pancreatic ductal adenocarcinoma 1 | 1,109
subependymal giant cell astrocytoma 1 | 2,287

Tissue

Blood and immune system 6 | 16,909
Cardiovascular System 6 | 15,192
Digestive Tract 6 | 17,369
Endocrine System 6 | 18,159
Female tissues 6 | 17,400
Liver and Pancreas 6 | 16,750
Male tissues 6 | 17,142
Nervous System 6 | 16,725
Respiratory system 6 | 16,393
Skin and soft tissues 6 | 17,230
Urinary Tract 6 | 16,678

Target Family

Non-IDG 6 | 12,091

GO Function

protein transmembrane transpor... 6 | 6
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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