Development Level

Tbio 37 | 11,445
Tchem 10 | 1,598
Tdark 5 | 6,588
Tclin 1 | 613

IMPC Phenotype

abnormal bone structure 4 | 187
decreased bone mineral content 4 | 151
preweaning lethality, complete... 4 | 979
preweaning lethality, incomple... 4 | 499
abnormal behavior 3 | 298
increased lean body mass 3 | 172
brachydactyly 2 | 19
decreased body length 2 | 101
decreased circulating glucose ... 2 | 126
decreased circulating triglyce... 2 | 79
decreased lean body mass 2 | 135
decreased total body fat amoun... 2 | 207
hypoactivity 2 | 132
increased lymphocyte cell numb... 2 | 32
syndactyly 2 | 23
abnormal coat-hair pigmentatio... 1 | 64
abnormal eye morphology 1 | 68
abnormal rib morphology 1 | 10
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
decreased threshold for audito... 1 | 26
decreased total retina thickne... 1 | 17
increased cardiac muscle contr... 1 | 8
increased fasted circulating g... 1 | 76
increased leukocyte cell numbe... 1 | 47
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
short tibia 1 | 97
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 35 | 11,493
ovarian cancer 31 | 8,520
osteosarcoma 29 | 7,950
glioblastoma 21 | 5,792
medulloblastoma, large-cell 21 | 6,241
atypical teratoid / rhabdoid tumor 20 | 5,112
ependymoma 17 | 4,679
adult high grade glioma 16 | 3,801
group 3 medulloblastoma 14 | 4,104
lung cancer 14 | 4,740
psoriasis 13 | 6,694
invasive ductal carcinoma 12 | 2,951
malignant mesothelioma 12 | 3,232
primitive neuroectodermal tumor 12 | 3,035
subependymal giant cell astrocytoma 12 | 2,287
Astrocytoma, Pilocytic 11 | 3,081
Breast cancer 11 | 3,578
astrocytic glioma 11 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
oligodendroglioma 11 | 2,850
Cancer 10 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
lung adenocarcinoma 9 | 2,716
Pick disease 8 | 1,894
colon cancer 8 | 1,478
group 4 medulloblastoma 8 | 1,855
interstitial cystitis 7 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
Endometriosis 6 | 540
Epilepsy 6 | 792
Rheumatoid arthritis 6 | 1,191
juvenile dermatomyositis 6 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
ulcerative colitis 6 | 1,819
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Intellectual disability 5 | 1,016
Mental and motor retardation 5 | 608
Multiple myeloma 5 | 1,332
Seizures 5 | 596
breast carcinoma 5 | 1,638
non-small cell lung cancer 5 | 2,890
pancreatic cancer 5 | 2,398
spina bifida 5 | 1,074
Atopic dermatitis 4 | 952
Dull intelligence 4 | 645
Kidney cancer 4 | 2,613
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Muscle hypotonia 4 | 571
Poor school performance 4 | 645
Waldenstrons macroglobulinemia 4 | 765
acute quadriplegic myopathy 4 | 1,158
diabetes mellitus 4 | 1,728
ductal carcinoma in situ 4 | 1,745
pituitary cancer 4 | 1,972
tuberculosis 4 | 2,010
Alzheimer's disease 3 | 658
Autosomal recessive predisposition 3 | 1,442
Centronuclear myopathy 3 | 27
Crohn's disease 3 | 321
Downward slant of palpebral fissure 3 | 158
Endometrial cancer 3 | 311
Hydrocephalus 3 | 152
Lafora disease 3 | 9
Neurodevelopmental Disorders 3 | 70
Obesity 3 | 678
Orbital separation excessive 3 | 244
Parkinson's disease 3 | 392
Prostatic Neoplasms 3 | 495
active Crohn's disease 3 | 922
aldosterone-producing adenoma 3 | 665
dermatomyositis 3 | 966
Concave bridge of nose 2 | 195
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Disease Progression 2 | 136
Down syndrome 2 | 499
Duchenne muscular dystrophy 2 | 601
Failure to gain weight 2 | 365
Hypoglycemia 2 | 152
Liver carcinoma 2 | 240
Pectus excavatum 2 | 100
Pediatric failure to thrive 2 | 365
Strabismus 2 | 270
Vascular disease 2 | 319
active ulcerative colitis 2 | 764
acute myeloid leukemia 2 | 783
adrenocortical carcinoma 2 | 1,428
astrocytoma 2 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
chronic rhinosinusitis 2 | 512
cystic fibrosis 2 | 1,696
esophageal adenocarcinoma 2 | 737
lung carcinoma 2 | 2,843
medulloblastoma 2 | 720
pancreatic carcinoma 2 | 562
pediatric high grade glioma 2 | 1,064
progressive supranuclear palsy 2 | 676

Tissue

Endocrine System 52 | 18,159
Blood and immune system 51 | 16,909
Female tissues 51 | 17,400
Liver and Pancreas 51 | 16,750
Male tissues 51 | 17,142
Nervous System 51 | 16,725
Respiratory system 51 | 16,393
Skin and soft tissues 51 | 17,230
Urinary Tract 51 | 16,678
Cardiovascular System 50 | 15,192
Digestive Tract 50 | 17,369

Target Family

Enzyme 50 | 4,145
Kinase 2 | 634
Non-IDG 1 | 12,091

GO Function

protein serine-threonine phosp... 53 | 53
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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