Development Level

Tchem 251 | 1,598
Tbio 77 | 11,445
Tdark 19 | 6,588
Tclin 13 | 613

Collection

Kinase: IDG Consortium (Target... 92 | 125
RFA-RM-18-021 92 | 328
Kinase: IDG Consortium (Comple... 28 | 37

IMPC Phenotype

preweaning lethality, complete... 23 | 979
preweaning lethality, incomple... 19 | 499
embryonic lethality prior to o... 11 | 239
abnormal bone structure 10 | 187
embryonic lethality prior to t... 10 | 278
abnormal embryo size 8 | 220
abnormal behavior 7 | 298
enlarged heart 7 | 210
decreased circulating glucose ... 6 | 126
decreased vertical activity 6 | 208
decreased total body fat amoun... 5 | 207
increased bone mineral content 5 | 108
increased circulating alkaline... 5 | 122
increased or absent threshold ... 5 | 101
decreased blood urea nitrogen ... 4 | 51
decreased body weight 4 | 161
decreased circulating serum al... 4 | 82
decreased lean body mass 4 | 135
decreased mean corpuscular hem... 4 | 50
enlarged spleen 4 | 41
increased circulating choleste... 4 | 66
increased heart weight 4 | 62
increased mean corpuscular vol... 4 | 92
increased total body fat amoun... 4 | 134
abnormal behavioral response t... 3 | 66
abnormal epididymis morphology 3 | 42
abnormal gait 3 | 69
abnormal heart morphology 3 | 162
abnormal lens morphology 3 | 81
abnormal retina morphology 3 | 71
abnormal seminal vesicle morph... 3 | 114
abnormal spleen morphology 3 | 55
decreased body length 3 | 101
decreased bone mineral content 3 | 151
decreased hematocrit 3 | 46
decreased leukocyte cell numbe... 3 | 73
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular vol... 3 | 79
decreased neutrophil cell numb... 3 | 42
decreased startle reflex 3 | 75
enlarged epididymis 3 | 31
enlarged lymph nodes 3 | 37
improved glucose tolerance 3 | 79
increased bone mineral density 3 | 72
increased circulating HDL chol... 3 | 80
increased circulating LDL chol... 3 | 13
increased circulating iron lev... 3 | 30
increased circulating sodium l... 3 | 71
increased lean body mass 3 | 172
increased monocyte cell number 3 | 63
male infertility 3 | 123
short tibia 3 | 97
abnormal clavicle morphology 2 | 6
abnormal cranium morphology 2 | 36
abnormal embryo turning 2 | 31
abnormal joint morphology 2 | 23
abnormal kidney morphology 2 | 65
abnormal neural tube closure 2 | 46
abnormal pelvic girdle bone mo... 2 | 12
abnormal skin morphology 2 | 50
abnormal spinal cord morpholog... 2 | 9
decreased circulating LDL chol... 2 | 38
decreased circulating bilirubi... 2 | 19
decreased circulating calcium ... 2 | 36
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased eosinophil cell numb... 2 | 24
decreased fasted circulating g... 2 | 65
decreased hemoglobin content 2 | 68
decreased large unstained cell... 2 | 11
decreased mean platelet volume 2 | 25
decreased prepulse inhibition 2 | 82
increased blood urea nitrogen ... 2 | 48
increased body length 2 | 32
increased circulating aspartat... 2 | 15
increased mean corpuscular hem... 2 | 96
increased mean platelet volume 2 | 45
increased neutrophil cell numb... 2 | 46
increased spleen weight 2 | 10
increased startle reflex 2 | 112
pallor 2 | 34
small superior vagus ganglion 2 | 74
small testis 2 | 58
thrombocytosis 2 | 27
abnormal craniofacial morpholo... 1 | 33
abnormal optic disc morphology 1 | 10
abnormal tooth morphology 1 | 24
convulsive seizures 1 | 13
decreased grip strength 1 | 116
decreased mean corpuscular hem... 1 | 31
decreased total retina thickne... 1 | 17
impaired pupillary reflex 1 | 26
increased circulating triglyce... 1 | 42
increased red blood cell distr... 1 | 34
long tibia 1 | 25
small thymus 1 | 16
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Carcinoma 301 | 11,493
ovarian cancer 207 | 8,520
osteosarcoma 200 | 7,950
medulloblastoma, large-cell 159 | 6,241
psoriasis 146 | 6,694
glioblastoma 144 | 5,792
atypical teratoid / rhabdoid tumor 138 | 5,112
ependymoma 124 | 4,679
lung cancer 120 | 4,740
Cancer 108 | 2,499
adult high grade glioma 101 | 3,801
group 3 medulloblastoma 97 | 4,104
Kidney cancer 96 | 2,613
Breast cancer 93 | 3,578
malignant mesothelioma 89 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 85 | 3,291
Astrocytoma, Pilocytic 82 | 3,081
primitive neuroectodermal tumor 77 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 75 | 2,989
non-small cell lung cancer 74 | 2,890
oligodendroglioma 69 | 2,850
invasive ductal carcinoma 67 | 2,951
astrocytic glioma 64 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 61 | 2,955
Pick disease 59 | 1,894
lung carcinoma 58 | 2,843
group 4 medulloblastoma 57 | 1,855
subependymal giant cell astrocytoma 57 | 2,287
pancreatic cancer 55 | 2,398
lung adenocarcinoma 53 | 2,716
interstitial cystitis 47 | 2,312
breast carcinoma 42 | 1,638
tuberculosis 42 | 2,010
Renal Cell Carcinoma 41 | 214
diabetes mellitus 41 | 1,728
adrenocortical carcinoma 39 | 1,428
pituitary cancer 39 | 1,972
Schizophrenia 38 | 1,160
cystic fibrosis 37 | 1,696
ductal carcinoma in situ 36 | 1,745
colon cancer 35 | 1,478
Rheumatoid arthritis 34 | 1,191
acute quadriplegic myopathy 34 | 1,158
ulcerative colitis 34 | 1,819
spina bifida 33 | 1,074
Intellectual disability 32 | 1,016
astrocytoma 31 | 1,146
juvenile dermatomyositis 30 | 1,187
Autosomal recessive predisposition 28 | 1,442
nasopharyngeal carcinoma 28 | 1,058
Gastrointestinal stromal tumor 27 | 62
Multiple myeloma 27 | 1,332
Liver cancer 26 | 604
Pancreatic Neuroendocrine Tumor 26 | 45
pediatric high grade glioma 26 | 1,064
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,962
Dull intelligence 24 | 645
Low intelligence 24 | 645
Mental Retardation 24 | 645
Mental deficiency 24 | 645
Parkinson's disease 24 | 392
Poor school performance 24 | 645
primary pancreatic ductal adenocarcinoma 24 | 1,109
progressive supranuclear palsy 23 | 676
Chronic Myelocytic Leukemia Accelerated Phase 22 | 59
Melanoma 22 | 711
acute myeloid leukemia 22 | 783
dermatomyositis 22 | 966
medulloblastoma 22 | 720
Alzheimer's disease 21 | 658
Blastic phase chronic myeloid leukemia 21 | 58
Endometriosis 21 | 540
Epilepsy 21 | 792
Atopic dermatitis 20 | 952
Amyotrophic lateral sclerosis 19 | 451
Prostatic Neoplasms 19 | 495
Short stature 19 | 531
Down syndrome 18 | 499
Hamman-Rich syndrome 18 | 34
Hypoplastic mandible condyle 18 | 275
Mandibular hypoplasia 18 | 275
Micrognathism 18 | 275
Small head 18 | 374
primary Sjogren syndrome 18 | 735
Bipolar Disorder 17 | 666
Breast Neoplasms 17 | 445
Cognitive delay 17 | 608
Global developmental delay 17 | 608
Hypertension 17 | 396
Mammary Neoplasms 17 | 425
Mental and motor retardation 17 | 608
Endometrial cancer 16 | 311
Vascular disease 16 | 319
Waldenstrons macroglobulinemia 16 | 765
esophageal adenocarcinoma 16 | 737
Chronic Lymphocytic Leukemia 15 | 262
Depressive disorder 15 | 409
Obesity 15 | 678
Seizures 15 | 596
aldosterone-producing adenoma 15 | 665

Tissue

Endocrine System 353 | 18,159
Digestive Tract 347 | 17,369
Male tissues 347 | 17,142
Female tissues 346 | 17,400
Skin and soft tissues 346 | 17,230
Nervous System 344 | 16,725
Liver and Pancreas 343 | 16,750
Urinary Tract 342 | 16,678
Blood and immune system 341 | 16,909
Respiratory system 339 | 16,393
Cardiovascular System 332 | 15,192

Target Family

Kinase 338 | 634
Enzyme 10 | 4,145
Non-IDG 9 | 12,091
Epigenetic 1 | 242
Ion Channel 1 | 344
Transcription Factor 1 | 1,400

GO Function

protein serine-threonine kinas... 360 | 360
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
TRAF2 and NCK-interacting protein kinase TNIK Tchem Kinase -1.33394 28.5 441
Serine/threonine-protein kinase pim-3 PIM3 Tchem Kinase -1.87886 77.4 105
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Serine/threonine-protein kinase TAO2 TAOK2 Tchem Kinase -1.52454 36.1 154
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Serine/threonine-protein kinase 24 STK24 Tchem Kinase -2.24110 132.9 243
PAS domain-containing serine/threonine-protein kinase PASK Tbio Kinase -1.01354 12.3 95
Dual specificity tyrosine-phosphorylation-regulated kinase 1A DYRK1A Tchem Kinase -2.68760 506.6 336
Ribosomal protein S6 kinase alpha-6 RPS6KA6 Tchem Kinase -1.26563 21.6 158
Serine/threonine-protein kinase SMG1 SMG1 Tchem Kinase -1.61615 60.9 195