Development Level

Tbio 35 | 10,625
Tchem 10 | 1,890
Tdark 6 | 7,003
Tclin 1 | 602

IMPC Term

abnormal bone structure 2 | 131
decreased circulating triglyce... 2 | 83
decreased fasted circulating g... 2 | 49
increased or absent threshold ... 2 | 128
preweaning lethality, complete... 2 | 633
abnormal QRS complex 1 | 25
abnormal behavior 1 | 226
abnormal coat/hair pigmentatio... 1 | 54
abnormal retinal outer nuclear... 1 | 5
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased circulating HDL chol... 1 | 77
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased circulating magnesiu... 1 | 11
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 19
decreased neutrophil cell numb... 1 | 37
decreased rib number 1 | 59
decreased thoracic vertebrae n... 1 | 7
decreased threshold for audito... 1 | 32
decreased total body fat amoun... 1 | 186
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased fasted circulating g... 1 | 68
increased heart weight 1 | 37
increased lean body mass 1 | 107
increased lymphocyte cell numb... 1 | 9
limb grasping 1 | 35
preweaning lethality, incomple... 1 | 260
vertebral fusion 1 | 23

Disease

ovarian cancer 33 | 8,492
osteosarcoma 29 | 7,933
glioblastoma 21 | 5,572
medulloblastoma, large-cell 21 | 6,234
atypical teratoid / rhabdoid tumor 19 | 4,369
lung cancer 13 | 4,473
ependymoma 12 | 2,514
primitive neuroectodermal tumor 12 | 3,031
psoriasis 12 | 6,685
Breast cancer 11 | 3,099
invasive ductal carcinoma 11 | 2,950
malignant mesothelioma 11 | 3,163
oligodendroglioma 11 | 2,849
subependymal giant cell astrocytoma 11 | 2,287
adult high grade glioma 10 | 2,148
astrocytic glioma 10 | 2,241
group 4 medulloblastoma 10 | 1,875
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,289
pilocytic astrocytoma 10 | 3,086
Pick disease 9 | 1,893
lung adenocarcinoma 9 | 2,714
pediatric high grade glioma 9 | 2,712
colon cancer 8 | 1,475
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
Cancer 7 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
posterior fossa group A ependymoma 7 | 1,511
ulcerative colitis 7 | 2,087
Rheumatoid Arthritis 6 | 1,171
group 3 medulloblastoma 6 | 2,254
interstitial cystitis 6 | 2,299
juvenile dermatomyositis 6 | 1,189
medulloblastoma 6 | 1,524
pancreatic cancer 6 | 2,300
spina bifida 6 | 1,064
Endometriosis 5 | 535
Multiple myeloma 5 | 1,328
diabetes mellitus 5 | 1,663
Atopic dermatitis 4 | 944
Intellectual disability 4 | 573
Waldenstrons macroglobulinemia 4 | 765
acute myeloid leukemia 4 | 785
acute quadriplegic myopathy 4 | 1,157
ductal carcinoma in situ 4 | 1,745
non-small cell lung cancer 4 | 2,798
Centronuclear myopathy 3 | 21
Crohn's disease 3 | 304
Endometrial cancer 3 | 32
IGA Glomerulonephritis 3 | 454
Lafora disease 3 | 9
Parkinson's disease 3 | 364
active Crohn's disease 3 | 918
aldosterone-producing adenoma 3 | 664
astrocytoma 3 | 1,493
breast carcinoma 3 | 1,614
dermatomyositis 3 | 967
non primary Sjogren syndrome sicca 3 | 840
pituitary cancer 3 | 1,972
Acquired metabolic disease 2 | 267
Alzheimer's disease 2 | 644
Carcinoma 2 | 2,147
Disease Progression 2 | 125
Duchenne muscular dystrophy 2 | 602
Glioma 2 | 66
Hepatolenticular Degeneration 2 | 24
Kidney cancer 2 | 121
Malignant neoplasm of prostate 2 | 67
Mammary Neoplasms 2 | 410
Melanoma 2 | 261
Neurodegenerative disease 2 | 383
Peripheral Neuropathy 2 | 303
Prostatic Neoplasms 2 | 471
Renal Cell Carcinoma 2 | 199
Vascular disease 2 | 281
adrenocortical carcinoma 2 | 1,427
atypical teratoid/rhabdoid tumor 2 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
chronic rhinosinusitis 2 | 512
cystic fibrosis 2 | 1,670
esophageal adenocarcinoma 2 | 737
gastric cancer 2 | 436
head and neck cancer and chronic obstructive pulmonary disease 2 | 237
hepatocellular carcinoma 2 | 550
hereditary spastic paraplegia 2 | 313
lung carcinoma 2 | 2,844
ovarian neoplasm 2 | 97
pancreatic carcinoma 2 | 567
primary pancreatic ductal adenocarcinoma 2 | 1,271
progressive supranuclear palsy 2 | 674
sarcoidosis 2 | 368
sonic hedgehog group medulloblastoma 2 | 1,482
tuberculosis 2 | 1,563
tuberculosis and treatment for 6 months 2 | 686
Cornea plana 1 | 12
Malignant tumor of prostate 1 | 26
Meningioma 1 | 27
Papilloma 1 | 27
Toxic shock syndrome 1 | 28
Tularemia 1 | 22

Tissue

Blood and immune system 51 | 17,995
Cardiovascular System 51 | 17,958
Digestive Tract 51 | 18,473
Endocrine System 51 | 18,512
Female tissues 51 | 18,647
Liver and Pancreas 51 | 18,136
Male tissues 51 | 17,969
Nervous System 51 | 18,561
Respiratory system 51 | 17,484
Skin and soft tissues 51 | 18,115
Urinary Tract 51 | 18,444

Target Family

Enzyme 50 | 4,146
Kinase 2 | 634

GO Function

protein serine/threonine phosp... 52 | 52
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

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