Development Level

Tchem 221 | 1,890
Tbio 85 | 10,625
Tdark 19 | 7,003
Tclin 11 | 602

Collection

Eligible Kinase Proteins 85 | 134

IMPC Term

preweaning lethality, complete... 16 | 633
preweaning lethality, incomple... 10 | 260
abnormal behavior 6 | 226
decreased body weight 6 | 174
decreased circulating glucose ... 6 | 121
decreased lean body mass 6 | 195
decreased body length 5 | 108
decreased total body fat amoun... 5 | 186
embryonic lethality prior to t... 5 | 187
abnormal bone structure 4 | 131
abnormal lens morphology 4 | 73
decreased bone mineral content 4 | 157
embryonic lethality prior to o... 4 | 148
increased bone mineral content 4 | 92
increased circulating alkaline... 4 | 119
abnormal embryo size 3 | 112
abnormal gait 3 | 51
abnormal retina morphology 3 | 100
decreased blood urea nitrogen ... 3 | 31
decreased circulating triglyce... 3 | 83
decreased neutrophil cell numb... 3 | 37
increased circulating LDL chol... 3 | 15
increased circulating choleste... 3 | 53
increased circulating iron lev... 3 | 25
increased mean corpuscular vol... 3 | 91
increased or absent threshold ... 3 | 128
abnormal behavioral response t... 2 | 52
abnormal bone mineralization 2 | 55
abnormal joint morphology 2 | 14
abnormal kidney morphology 2 | 30
abnormal maxilla morphology 2 | 16
abnormal pelvic girdle bone mo... 2 | 11
abnormal seminal vesicle morph... 2 | 47
abnormal sleep behavior 2 | 63
abnormal snout morphology 2 | 18
abnormal tooth morphology 2 | 24
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 37
decreased circulating serum al... 2 | 79
decreased eosinophil cell numb... 2 | 41
decreased fasted circulating g... 2 | 49
decreased grip strength 2 | 123
decreased leukocyte cell numbe... 2 | 54
enlarged heart 2 | 111
improved glucose tolerance 2 | 56
increased bone mineral density 2 | 52
increased circulating aspartat... 2 | 17
increased circulating sodium l... 2 | 71
increased heart weight 2 | 37
increased hemoglobin content 2 | 45
increased mature B cell number 2 | 12
increased mean corpuscular hem... 2 | 93
increased total body fat amoun... 2 | 57
short tibia 2 | 82
small superior vagus ganglion 2 | 20
small testis 2 | 37
abnormal cranium morphology 1 | 32
abnormal eye morphology 1 | 38
abnormal heart morphology 1 | 51
abnormal locomotor activation 1 | 26
abnormal respiratory quotient 1 | 9
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
convulsive seizures 1 | 11
craniofacial phenotype 1 | 9
decreased Ly6C high monocyte n... 1 | 18
decreased cardiac muscle contr... 1 | 5
decreased cervical vertebrae n... 1 | 12
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating magnesiu... 1 | 11
decreased circulating potassiu... 1 | 17
decreased circulating sodium l... 1 | 18
decreased gamma-delta T cell n... 1 | 18
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased mean corpuscular hem... 1 | 34
dilated heart left ventricle 1 | 10
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
hydrops fetalis 1 | 22
increased NK cell number 1 | 19
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating glucose ... 1 | 16
increased eosinophil cell numb... 1 | 9
increased grip strength 1 | 83
increased sacral vertebrae num... 1 | 62
lethargy 1 | 5
long tibia 1 | 13
microphthalmia 1 | 15
small thymus 1 | 11
thrombocytopenia 1 | 46
tremors 1 | 34

Disease

osteosarcoma 187 | 7,933
ovarian cancer 187 | 8,484
medulloblastoma, large-cell 149 | 6,234
psoriasis 138 | 6,685
glioblastoma 125 | 5,572
atypical teratoid / rhabdoid tumor 109 | 4,369
lung cancer 101 | 4,466
Cancer 92 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 82 | 3,289
malignant mesothelioma 80 | 3,162
Breast cancer 77 | 3,094
pilocytic astrocytoma 77 | 3,086
Carcinoma 75 | 2,147
pediatric high grade glioma 73 | 2,712
primitive neuroectodermal tumor 73 | 3,031
ependymoma 72 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 72 | 2,988
non-small cell lung cancer 69 | 2,798
oligodendroglioma 65 | 2,849
invasive ductal carcinoma 63 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 59 | 2,956
lung carcinoma 55 | 2,844
Pick disease 53 | 1,893
astrocytic glioma 52 | 2,241
lung adenocarcinoma 52 | 2,713
subependymal giant cell astrocytoma 51 | 2,287
group 4 medulloblastoma 49 | 1,875
interstitial cystitis 47 | 2,299
pancreatic cancer 47 | 2,300
group 3 medulloblastoma 46 | 2,254
adult high grade glioma 45 | 2,148
medulloblastoma 45 | 1,524
Renal Cell Carcinoma 38 | 199
adrenocortical carcinoma 38 | 1,427
ulcerative colitis 38 | 2,087
astrocytoma 36 | 1,493
cystic fibrosis 35 | 1,665
breast carcinoma 34 | 1,614
diabetes mellitus 34 | 1,663
ductal carcinoma in situ 34 | 1,745
posterior fossa group B ependymoma 34 | 1,530
pituitary cancer 33 | 1,972
acute quadriplegic myopathy 32 | 1,157
colon cancer 32 | 1,475
sonic hedgehog group medulloblastoma 32 | 1,482
spina bifida 31 | 1,064
Rheumatoid Arthritis 29 | 1,160
juvenile dermatomyositis 28 | 1,189
posterior fossa group A ependymoma 28 | 1,511
Gastrointestinal stromal tumor 27 | 61
Pancreatic Neuroendocrine Tumor 26 | 45
atypical teratoid/rhabdoid tumor 26 | 1,095
nasopharyngeal carcinoma 26 | 1,056
primary pancreatic ductal adenocarcinoma 24 | 1,271
tuberculosis 24 | 1,557
Multiple myeloma 23 | 1,327
Parkinson's disease 22 | 364
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,795
progressive supranuclear palsy 21 | 674
Chronic Myelocytic Leukemia Accelerated Phase 20 | 59
IGA Glomerulonephritis 20 | 454
acute myeloid leukemia 20 | 780
dermatomyositis 20 | 933
Alzheimer's disease 19 | 644
Atopic dermatitis 19 | 944
Blastic phase chronic myeloid leukemia 19 | 58
Down syndrome 19 | 548
Amyotrophic Lateral Sclerosis 18 | 431
tuberculosis and treatment for 6 months 18 | 686
Endometriosis 17 | 535
Intellectual disability 17 | 573
primary Sjogren syndrome 17 | 789
Hamman-Rich syndrome 16 | 35
Peripheral Neuropathy 16 | 303
Prostatic Neoplasms 16 | 471
esophageal adenocarcinoma 16 | 737
Schizophrenia 15 | 501
Waldenstrons macroglobulinemia 15 | 765
aldosterone-producing adenoma 15 | 664
Mammary Neoplasms 14 | 410
Vascular disease 14 | 281
cutaneous lupus erythematosus 14 | 1,056
Colorectal Neoplasms 12 | 217
Kidney disease 12 | 396
Melanoma 12 | 261
Neurodegenerative disease 12 | 383
Asthma 11 | 349
Chronic Lymphocytic Leukemia 11 | 242
Hypertension 11 | 287
Lung Neoplasms 11 | 171
Obesity 11 | 616
glioblastoma multiforme 11 | 347
non-small cell lung carcinoma 11 | 413
pancreatic carcinoma 11 | 567
Epilepsy 10 | 346
Microcephaly 10 | 149
active Crohn's disease 10 | 918
gastric carcinoma 10 | 832
non primary Sjogren syndrome sicca 10 | 840
tuberculosis and treatment for 3 months 10 | 327

Tissue

Endocrine System 334 | 18,512
Urinary Tract 334 | 18,444
Female tissues 333 | 18,647
Liver and Pancreas 333 | 18,136
Nervous System 333 | 18,561
Blood and immune system 332 | 17,995
Digestive Tract 332 | 18,473
Male tissues 332 | 17,969
Cardiovascular System 331 | 17,958
Respiratory system 329 | 17,484
Skin and soft tissues 328 | 18,115

Target Family

Kinase 322 | 634
Non-IDG 9 | 11,971
Enzyme 2 | 4,146
Epigenetic 1 | 242
Ion Channel 1 | 341
Transcription Factor 1 | 1,400

GO Function

protein serine/threonine kinas... 336 | 336
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Serine/threonine-protein kinase N3 PKN3 Tchem Kinase -1.11681 14.4 104
Homeodomain-interacting protein kinase 1 HIPK1 Tbio Kinase -0.62325 4.93 166
Serine/threonine kinase-like domain-containing protein STKLD1 STKLD1 Tdark Kinase 0.00000 156
Serine/threonine-protein kinase DCLK1 DCLK1 Tchem Kinase -1.97724 113.9 288
Homeodomain-interacting protein kinase 4 HIPK4 Tchem Kinase -0.20862 2.17 190
Mitogen-activated protein kinase kinase kinase MLT MAP3K20 Tchem Kinase -1.14470 13.6 205
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767