Development Level

Tbio 37 | 11,651
Tchem 9 | 1,388
Tclin 6 | 612
Tdark 3 | 6,593

IMPC Phenotype

preweaning lethality, complete... 4 | 979
preweaning lethality, incomple... 4 | 499
abnormal embryo size 2 | 220
abnormal retina morphology 2 | 71
embryonic lethality prior to t... 2 | 278
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
increased circulating alkaline... 1 | 122
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
microphthalmia 1 | 26
small testis 1 | 58

Disease

Carcinoma 41 | 11,493
ovarian cancer 31 | 8,520
glioblastoma 27 | 5,792
osteosarcoma 27 | 7,950
ependymoma 24 | 4,679
Cancer 23 | 2,499
psoriasis 21 | 6,694
lung cancer 20 | 4,740
medulloblastoma, large-cell 20 | 6,241
atypical teratoid / rhabdoid tumor 19 | 5,112
malignant mesothelioma 19 | 3,232
Astrocytoma, Pilocytic 18 | 3,081
adult high grade glioma 18 | 3,801
group 3 medulloblastoma 18 | 4,104
primitive neuroectodermal tumor 17 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
invasive ductal carcinoma 16 | 2,951
subependymal giant cell astrocytoma 16 | 2,287
Breast cancer 15 | 3,578
lung carcinoma 15 | 2,843
oligodendroglioma 15 | 2,850
astrocytic glioma 14 | 2,597
Autosomal recessive predisposition 13 | 1,442
lung adenocarcinoma 13 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
pancreatic cancer 12 | 2,398
Kidney cancer 11 | 2,613
breast carcinoma 11 | 1,638
diabetes mellitus 11 | 1,728
non-small cell lung cancer 11 | 2,890
cystic fibrosis 10 | 1,696
interstitial cystitis 10 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
ductal carcinoma in situ 9 | 1,745
group 4 medulloblastoma 9 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
pituitary cancer 9 | 1,972
Intellectual disability 8 | 1,016
Schizophrenia 8 | 1,160
dermatomyositis 8 | 966
juvenile dermatomyositis 8 | 1,187
tuberculosis 8 | 2,010
Dull intelligence 7 | 645
Epilepsy 7 | 792
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Pick disease 7 | 1,894
Poor school performance 7 | 645
Seizures 7 | 596
mucosa-associated lymphoid tissue lymphoma 7 | 484
ulcerative colitis 7 | 1,819
Atopic dermatitis 6 | 952
Immune system cancer 6 | 140
Lymphoid leukemia 6 | 160
Multiple Sclerosis 6 | 540
Multiple myeloma 6 | 1,332
Rheumatoid arthritis 6 | 1,191
adrenocortical carcinoma 6 | 1,428
cutaneous lupus erythematosus 6 | 1,057
Alzheimer's disease 5 | 658
Anemia 5 | 365
Kidney disease 5 | 430
Liver cancer 5 | 604
Mesothelioma, Malignant 5 | 105
Myocardial Ischemia 5 | 169
Obesity 5 | 678
Skin cancer 5 | 469
Waldenstrons macroglobulinemia 5 | 765
atypical teratoid/rhabdoid tumor 5 | 357
nasopharyngeal carcinoma 5 | 1,058
pediatric high grade glioma 5 | 1,064
spina bifida 5 | 1,074
Asthma 4 | 385
Atherosclerosis 4 | 291
Autism spectrum disorder 4 | 101
Cell Transformation, Neoplastic 4 | 97
Constipation 4 | 181
Heart disease 4 | 306
Hepatomegaly 4 | 285
Hyperhidrosis disorder 4 | 81
Hypertensive disease 4 | 292
Increased sweating 4 | 81
Lymphoma 4 | 81
Melanoma 4 | 711
Neoplastic Cell Transformation 4 | 89
Neurodegenerative disease 4 | 414
Renal Cell Carcinoma 4 | 214
Short stature 4 | 531
Splenomegaly 4 | 190
Sweating 4 | 81
Type 2 diabetes mellitus 4 | 272
active ulcerative colitis 4 | 764
acute myeloid leukemia 4 | 783
hepatocellular carcinoma 4 | 547
non-small cell lung carcinoma 4 | 317
primary pancreatic ductal adenocarcinoma 4 | 1,109
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Polycystic ovary syndrome 3 | 360
progressive supranuclear palsy 3 | 676

Tissue

Female tissues 54 | 17,400
Blood and immune system 53 | 16,909
Digestive Tract 53 | 17,369
Endocrine System 53 | 18,159
Skin and soft tissues 53 | 17,230
Liver and Pancreas 52 | 16,750
Nervous System 52 | 16,725
Male tissues 51 | 17,142
Urinary Tract 51 | 16,678
Respiratory system 50 | 16,393
Cardiovascular System 48 | 15,192

Target Family

Non-IDG 28 | 12,091
Enzyme 10 | 4,145
Transcription Factor 7 | 1,400
Kinase 4 | 634
Transporter 3 | 473
GPCR 1 | 408
Ion Channel 1 | 344
Nuclear Receptor 1 | 48

GO Function

protein self-association 55 | 55
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Spectrin beta chain, non-erythrocytic 5 SPTBN5 Tbio Non-IDG -0.41365 2.99 32
B-cell lymphoma/leukemia 10 BCL10 Tbio Non-IDG -0.53932 4.30 895
Radical S-adenosyl methionine domain-containing protein 2 RSAD2 Tbio Non-IDG -1.99883 103.3 117
Transmembrane protein 43 TMEM43 Tbio Non-IDG -1.19270 17.2 71
Myeloid differentiation primary response protein MyD88 MYD88 Tbio Non-IDG -3.26747 1795.4 672
Heat shock factor protein 1 HSF1 Tbio Transcription Factor -2.27852 217.0 1246
E3 ubiquitin-protein ligase ZSWIM2 ZSWIM2 Tbio Enzyme -2.28388 186.1 92
Vesicle-associated membrane protein 2 VAMP2 Tbio Non-IDG -2.53335 323.7 203
SH3 and multiple ankyrin repeat domains protein 3 SHANK3 Tbio Non-IDG -2.26648 182.9 0
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298