Development Level

Tbio 25 | 10,625
Tchem 17 | 1,890
Tclin 7 | 602
Tdark 1 | 7,003

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 633
abnormal embryo size 2 | 112
decreased body weight 2 | 174
decreased circulating creatini... 2 | 31
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 30
abnormal startle reflex 1 | 14
decreased basophil cell number 1 | 11
decreased bone mineral content 1 | 157
decreased circulating HDL chol... 1 | 77
decreased circulating aspartat... 1 | 27
decreased circulating choleste... 1 | 85
decreased coping response 1 | 5
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased exploration in new e... 1 | 9
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased leukocyte cell numbe... 1 | 54
decreased neutrophil cell numb... 1 | 37
decreased total body fat amoun... 1 | 186
edema 1 | 11
embryonic growth retardation 1 | 28
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged lymph nodes 1 | 27
hypoactivity 1 | 89
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating chloride... 1 | 43
increased circulating phosphat... 1 | 24
increased erythrocyte cell num... 1 | 26
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
prenatal lethality 1 | 16
tremors 1 | 34

Disease

ovarian cancer 35 | 8,491
osteosarcoma 33 | 7,933
psoriasis 28 | 6,685
Cancer 26 | 2,346
atypical teratoid / rhabdoid tumor 22 | 4,369
glioblastoma 22 | 5,572
lung cancer 22 | 4,473
medulloblastoma, large-cell 22 | 6,234
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,289
malignant mesothelioma 14 | 3,163
primitive neuroectodermal tumor 14 | 3,031
Carcinoma 13 | 2,147
pancreatic cancer 13 | 2,300
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,988
lung adenocarcinoma 12 | 2,714
pilocytic astrocytoma 12 | 3,086
Breast cancer 11 | 3,098
diabetes mellitus 11 | 1,663
non-small cell lung cancer 11 | 2,798
oligodendroglioma 11 | 2,849
Rheumatoid Arthritis 10 | 1,170
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,956
lung carcinoma 10 | 2,844
medulloblastoma 10 | 1,524
pituitary cancer 10 | 1,972
Lung Neoplasms 9 | 171
Pick disease 9 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
pediatric high grade glioma 9 | 2,712
subependymal giant cell astrocytoma 9 | 2,287
ulcerative colitis 9 | 2,087
Adenocarcinoma 8 | 115
Prostatic Neoplasms 8 | 471
Vascular disease 8 | 281
adult high grade glioma 8 | 2,148
ependymoma 8 | 2,514
interstitial cystitis 8 | 2,299
Mammary Neoplasms 7 | 410
astrocytoma 7 | 1,493
ductal carcinoma in situ 7 | 1,745
invasive ductal carcinoma 7 | 2,950
juvenile dermatomyositis 7 | 1,189
non-small cell lung carcinoma 7 | 413
ovarian neoplasm 7 | 97
primary pancreatic ductal adenocarcinoma 7 | 1,271
Liver carcinoma 6 | 217
Multiple myeloma 6 | 1,327
Squamous cell carcinoma 6 | 96
Stomach Neoplasms 6 | 282
Waldenstrons macroglobulinemia 6 | 764
adrenocortical carcinoma 6 | 1,427
astrocytic glioma 6 | 2,241
colon cancer 6 | 1,475
group 3 medulloblastoma 6 | 2,254
posterior fossa group B ependymoma 6 | 1,530
sonic hedgehog group medulloblastoma 6 | 1,482
Adenoma 5 | 165
Amyotrophic Lateral Sclerosis 5 | 432
Atopic dermatitis 5 | 944
Colonic Neoplasms 5 | 126
Liver neoplasms 5 | 108
Mammary Neoplasms, Experimental 5 | 149
Melanoma 5 | 261
Multiple Sclerosis 5 | 498
Neoplasm Metastasis 5 | 138
Renal Cell Carcinoma 5 | 199
acute quadriplegic myopathy 5 | 1,157
breast carcinoma 5 | 1,614
cystic fibrosis 5 | 1,670
posterior fossa group A ependymoma 5 | 1,511
tuberculosis 5 | 1,563
Alzheimer's disease 4 | 644
Animal Mammary Neoplasms 4 | 135
Barrett's esophagus 4 | 185
Cholangiocarcinoma 4 | 32
Esophageal Neoplasms 4 | 67
Glioma 4 | 66
Kidney cancer 4 | 121
Liver disease 4 | 219
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 499
chronic lymphocytic leukemia 4 | 244
esophageal adenocarcinoma 4 | 737
group 4 medulloblastoma 4 | 1,875
pancreatic carcinoma 4 | 567
progressive supranuclear palsy 4 | 674
Brain Ischemia 3 | 87
Endometriosis 3 | 535
Eye disease 3 | 55
Inflammatory bowel disease 3 | 142
Kidney disease 3 | 397
Pancreatic Neoplasm 3 | 79
Polycystic Ovary Syndrome 3 | 334
Schizophrenia 3 | 503
active Crohn's disease 3 | 918
acute myeloid leukemia 3 | 785
aldosterone-producing adenoma 3 | 664
atypical teratoid/rhabdoid tumor 3 | 1,095
hepatocellular carcinoma 3 | 550
nasopharyngeal carcinoma 3 | 1,056
spina bifida 3 | 1,064

Tissue

Blood and immune system 50 | 17,994
Cardiovascular System 50 | 17,957
Digestive Tract 50 | 18,472
Endocrine System 50 | 18,511
Female tissues 50 | 18,646
Liver and Pancreas 50 | 18,135
Male tissues 50 | 17,968
Nervous System 50 | 18,560
Respiratory system 50 | 17,483
Skin and soft tissues 50 | 18,114
Urinary Tract 50 | 18,443

Target Family

Non-IDG 17 | 11,969
Kinase 15 | 634
Enzyme 13 | 4,146
Transcription Factor 4 | 1,400
Ion Channel 1 | 341

GO Function

protein phosphatase binding 50 | 50
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine-threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
Protein phosphatase methylesterase 1 PPME1 Tchem Enzyme -1.49604 33.2 153
Leucine-rich repeat protein SHOC-2 SHOC2 Tbio Non-IDG -1.66913 50.1 144
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.75815 5706.6 1539
Eukaryotic translation initiation factor 2-alpha kinase 3 EIF2AK3 Tchem Kinase -3.01129 806.4 424
Heat shock factor protein 4 HSF4 Tbio Transcription Factor -2.80080 629.1 217
Cell division cycle protein 27 homolog CDC27 Tbio Non-IDG -1.94211 84.6 308
Signal transducer and activator of transcription 6 STAT6 Tchem Transcription Factor -2.87815 736.9 910
TNF receptor-associated factor 3 TRAF3 Tbio Non-IDG -2.48370 297.6 330
Tyrosine-protein kinase JAK1 JAK1 Tclin Kinase -2.73793 446.6 400