Development Level

Tbio 38 | 11,651
Tchem 18 | 1,388
Tclin 9 | 612
Tdark 3 | 6,593

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 9 | 979
abnormal embryo size 3 | 220
decreased total body fat amoun... 3 | 207
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating creatini... 2 | 39
decreased red blood cell distr... 2 | 41
hypoactivity 2 | 132
increased lean body mass 2 | 172
increased startle reflex 2 | 112
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal facial morphology 1 | 17
abnormal forebrain morphology 1 | 10
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal heart morphology 1 | 162
abnormal heart shape 1 | 5
abnormal hindbrain morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal limb morphology 1 | 13
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal startle reflex 1 | 15
abnormal tail morphology 1 | 25
anophthalmia 1 | 33
cleft palate 1 | 8
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased coping response 1 | 8
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged lymph nodes 1 | 37
exencephaly 1 | 2
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating chloride... 1 | 41
increased circulating sodium l... 1 | 71
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
microphthalmia 1 | 26
pallor 1 | 34
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
spina bifida 1 | 2
syndactyly 1 | 23
tremors 1 | 39

Disease

Carcinoma 54 | 11,493
osteosarcoma 46 | 7,950
ovarian cancer 44 | 8,520
psoriasis 39 | 6,694
Cancer 35 | 2,499
atypical teratoid / rhabdoid tumor 29 | 5,112
glioblastoma 29 | 5,792
lung cancer 29 | 4,740
medulloblastoma, large-cell 29 | 6,241
malignant mesothelioma 21 | 3,232
ependymoma 20 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
Kidney cancer 19 | 2,613
group 3 medulloblastoma 19 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
Breast cancer 17 | 3,578
lung adenocarcinoma 16 | 2,716
primitive neuroectodermal tumor 16 | 3,035
Astrocytoma, Pilocytic 15 | 3,081
adult high grade glioma 15 | 3,801
non-small cell lung cancer 15 | 2,890
pancreatic cancer 15 | 2,398
diabetes mellitus 14 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
lung carcinoma 14 | 2,843
oligodendroglioma 14 | 2,850
subependymal giant cell astrocytoma 14 | 2,287
invasive ductal carcinoma 13 | 2,951
Rheumatoid arthritis 12 | 1,191
interstitial cystitis 12 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
pituitary cancer 12 | 1,972
ulcerative colitis 12 | 1,819
Autosomal recessive predisposition 11 | 1,442
astrocytic glioma 11 | 2,597
breast carcinoma 11 | 1,638
ductal carcinoma in situ 11 | 1,745
Breast Neoplasms 10 | 445
Lung Neoplasms 10 | 232
Pick disease 10 | 1,894
Schizophrenia 10 | 1,160
Stomach Neoplasms 10 | 300
astrocytoma 10 | 1,146
tuberculosis 10 | 2,010
Adenocarcinoma 9 | 122
Mammary Neoplasms 9 | 425
Prostatic Neoplasms 9 | 495
juvenile dermatomyositis 9 | 1,187
Carcinoma, Hepatocellular 8 | 228
Liver carcinoma 8 | 240
Multiple Sclerosis 8 | 540
Neoplasm Metastasis 8 | 168
Vascular disease 8 | 319
adrenocortical carcinoma 8 | 1,428
group 4 medulloblastoma 8 | 1,855
Atopic dermatitis 7 | 952
Diarrhea 7 | 253
Immune system cancer 7 | 140
Intellectual disability 7 | 1,016
Lymphoid leukemia 7 | 160
Melanoma 7 | 711
Ovarian Neoplasms 7 | 102
Renal Cell Carcinoma 7 | 214
colon cancer 7 | 1,478
medulloblastoma 7 | 720
ovarian neoplasm 7 | 99
Adenoma 6 | 167
Bipolar Disorder 6 | 666
Colonic Neoplasms 6 | 142
Dull intelligence 6 | 645
Liver cancer 6 | 604
Liver disease 6 | 237
Liver neoplasms 6 | 130
Low intelligence 6 | 645
Lung disease 6 | 142
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Multiple myeloma 6 | 1,332
Obesity 6 | 678
Polycystic ovary syndrome 6 | 360
Poor school performance 6 | 645
Squamous cell carcinoma 6 | 129
Waldenstrons macroglobulinemia 6 | 765
esophageal adenocarcinoma 6 | 737
non-small cell lung carcinoma 6 | 317
pediatric high grade glioma 6 | 1,064
primary pancreatic ductal adenocarcinoma 6 | 1,109
Alcoholic Intoxication, Chronic 5 | 289
Alzheimer's disease 5 | 658
Amyotrophic lateral sclerosis 5 | 451
Arthritis 5 | 290
Chronic Lymphocytic Leukemia 5 | 262
Infantile onset 5 | 238
Liver Cirrhosis, Experimental 5 | 769
Neurodegenerative disease 5 | 414
Pancreatic Neoplasms 5 | 85
acute myeloid leukemia 5 | 783
acute quadriplegic myopathy 5 | 1,158
cystic fibrosis 5 | 1,696
spina bifida 5 | 1,074

Tissue

Digestive Tract 67 | 17,369
Endocrine System 67 | 18,159
Female tissues 67 | 17,400
Respiratory system 67 | 16,393
Skin and soft tissues 67 | 17,230
Urinary Tract 67 | 16,678
Blood and immune system 66 | 16,909
Liver and Pancreas 66 | 16,750
Male tissues 66 | 17,142
Nervous System 66 | 16,725
Cardiovascular System 65 | 15,192

Target Family

Non-IDG 29 | 12,091
Kinase 17 | 634
Enzyme 15 | 4,145
Transcription Factor 4 | 1,400
Epigenetic 1 | 242
Ion Channel 1 | 344
Nuclear Receptor 1 | 48

GO Function

protein phosphatase binding 68 | 68
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase JAK3 JAK3 Tclin Kinase -2.64385 453.7 292
Src kinase-associated phosphoprotein 1 SKAP1 Tbio Enzyme -1.31527 25.2 175
Myotubularin-related protein 9 MTMR9 Tbio Non-IDG -0.73836 6.81 80
Anaphase-promoting complex subunit 5 ANAPC5 Tbio Enzyme -1.45912 28.7 251
Insulin receptor substrate 2 IRS2 Tbio Non-IDG -2.64133 414.7 227
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.81500 6459.7 1749
Receptor of activated protein C kinase 1 RACK1 Tbio Non-IDG -2.60480 437.9 300