Development Level

Tbio 45 | 11,651
Tdark 13 | 6,593
Tchem 2 | 1,388

IMPC Phenotype

abnormal heart morphology 3 | 162
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
anophthalmia 2 | 33
decreased grip strength 2 | 116
enlarged heart 2 | 210
preweaning lethality, incomple... 2 | 499
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal facial morphology 1 | 17
abnormal head shape 1 | 10
abnormal lung morphology 1 | 26
abnormal outer ear morphology 1 | 3
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
decreased circulating insulin ... 1 | 76
decreased lean body mass 1 | 135
decreased vertical activity 1 | 208
edema 1 | 59
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
increased heart weight 1 | 62
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
microphthalmia 1 | 26
preweaning lethality, complete... 1 | 979
small seminal vesicle 1 | 10
small testis 1 | 58

Disease

Carcinoma 37 | 11,493
glioblastoma 31 | 5,792
osteosarcoma 30 | 7,950
ovarian cancer 30 | 8,520
psoriasis 29 | 6,694
medulloblastoma, large-cell 28 | 6,241
lung cancer 26 | 4,740
atypical teratoid / rhabdoid tumor 24 | 5,112
adult high grade glioma 20 | 3,801
ependymoma 18 | 4,679
Astrocytoma, Pilocytic 15 | 3,081
oligodendroglioma 15 | 2,850
invasive ductal carcinoma 14 | 2,951
non-small cell lung cancer 14 | 2,890
breast carcinoma 13 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
lung carcinoma 12 | 2,843
malignant mesothelioma 12 | 3,232
pancreatic cancer 12 | 2,398
pituitary cancer 12 | 1,972
subependymal giant cell astrocytoma 12 | 2,287
ulcerative colitis 12 | 1,819
Breast cancer 11 | 3,578
astrocytic glioma 11 | 2,597
group 4 medulloblastoma 11 | 1,855
lung adenocarcinoma 11 | 2,716
primitive neuroectodermal tumor 11 | 3,035
Cancer 10 | 2,499
adrenocortical carcinoma 10 | 1,428
group 3 medulloblastoma 9 | 4,104
primary pancreatic ductal adenocarcinoma 9 | 1,109
tuberculosis 9 | 2,010
Kidney cancer 8 | 2,613
cystic fibrosis 8 | 1,696
diabetes mellitus 8 | 1,728
ductal carcinoma in situ 8 | 1,745
interstitial cystitis 8 | 2,312
juvenile dermatomyositis 8 | 1,187
Atopic dermatitis 7 | 952
Liver Cirrhosis, Experimental 7 | 769
Waldenstrons macroglobulinemia 7 | 765
colon cancer 7 | 1,478
gastric carcinoma 7 | 807
Duchenne muscular dystrophy 6 | 601
active ulcerative colitis 6 | 764
acute quadriplegic myopathy 6 | 1,158
aldosterone-producing adenoma 6 | 665
astrocytoma 6 | 1,146
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Rheumatoid arthritis 5 | 1,191
Schizophrenia 5 | 1,160
active Crohn's disease 5 | 922
cutaneous lupus erythematosus 5 | 1,057
non primary Sjogren syndrome sicca 5 | 891
Autosomal recessive predisposition 4 | 1,442
Multiple Sclerosis 4 | 540
Multiple myeloma 4 | 1,332
Prostatic Neoplasms 4 | 495
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
esophageal adenocarcinoma 4 | 737
limb girdle muscular dystrophy 2A 4 | 213
medulloblastoma 4 | 720
mucosa-associated lymphoid tissue lymphoma 4 | 484
pediatric high grade glioma 4 | 1,064
Atherosclerosis 3 | 291
Degenerative disc disease 3 | 35
Dermatitis, Allergic Contact 3 | 67
Down syndrome 3 | 499
Endometrial Neoplasms 3 | 55
Hypercalcemia 3 | 59
Lung Neoplasms 3 | 232
Osteoarthritis 3 | 184
Pick disease 3 | 1,894
Stomach Neoplasms 3 | 300
chronic rhinosinusitis 3 | 512
head and neck cancer 3 | 271
interstitial lung disease 3 | 298
nasopharyngeal carcinoma 3 | 1,058
nephrosclerosis 3 | 333
non diabetic and post-ischemic heart failure 3 | 200
primary Sjogren syndrome 3 | 735
sonic hedgehog group medulloblastoma 3 | 467
urothelial carcinoma 3 | 318
Adenoma 2 | 167
Bipolar Disorder 2 | 666
Cerebrovascular disease 2 | 238
Coronary artery disease 2 | 268
Epilepsy 2 | 792
Heart disease 2 | 306
Myocardial Ischemia 2 | 169
Polycystic ovary syndrome 2 | 360
Reperfusion Injury 2 | 86
chronic lymphosyte leukemia 2 | 204
dermatomyositis 2 | 966
fibroadenoma 2 | 559
pancreatic carcinoma 2 | 562
pterygium 2 | 76
type II diabetes mellitus and post-ischemic heart failure 2 | 88

Tissue

Endocrine System 60 | 18,159
Digestive Tract 58 | 17,369
Female tissues 58 | 17,400
Male tissues 58 | 17,142
Nervous System 58 | 16,725
Liver and Pancreas 57 | 16,750
Skin and soft tissues 57 | 17,230
Urinary Tract 57 | 16,678
Respiratory system 56 | 16,393
Blood and immune system 55 | 16,909
Cardiovascular System 55 | 15,192

Target Family

Non-IDG 48 | 12,091
Enzyme 8 | 4,145
Kinase 4 | 634

GO Function

protein kinase inhibitor activ... 60 | 60
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like DUS2 Tbio Enzyme -0.88176 8.73 109
Leucine-rich repeat-containing protein 4C LRRC4C Tbio Non-IDG -2.22551 163.3 161
Cytoplasmic protein NCK1 NCK1 Tbio Non-IDG -2.25032 186.5 398
Tribbles homolog 1 TRIB1 Tbio Kinase -1.74370 59.4 250
Tribbles homolog 3 TRIB3 Tbio Kinase -1.93599 97.7 421
Leucine-rich repeat transmembrane protein FLRT1 FLRT1 Tdark Non-IDG -0.54110 3.41 105
Dual specificity protein phosphatase 19 DUSP19 Tdark Enzyme -0.55139 4.50 122
Leucine-rich repeat and transmembrane domain-containing protein 2 LRTM2 Tdark Non-IDG 0.34 0.42 58
Leucine-rich repeat transmembrane neuronal protein 4 LRRTM4 Tdark Non-IDG -0.76467 4.56 69
Leucine-rich repeat transmembrane neuronal protein 1 LRRTM1 Tbio Non-IDG -1.27174 15.8 155