Development Level

Tbio 258 | 11,445
Tchem 92 | 1,598
Tclin 31 | 613
Tdark 29 | 6,588

Collection

Kinase: IDG Consortium (Comple... 5 | 37
Kinase: IDG Consortium (Target... 3 | 125
GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 46 | 979
embryonic lethality prior to t... 16 | 278
embryonic lethality prior to o... 12 | 239
preweaning lethality, incomple... 12 | 499
abnormal embryo size 10 | 220
decreased vertical activity 8 | 208
abnormal behavior 7 | 298
decreased total body fat amoun... 7 | 207
enlarged heart 7 | 210
increased mean corpuscular hem... 7 | 96
abnormal heart morphology 6 | 162
abnormal retina morphology 6 | 71
cataract 6 | 92
decreased mean corpuscular vol... 6 | 79
increased mean corpuscular vol... 6 | 92
male infertility 6 | 123
abnormal lens morphology 5 | 81
decreased bone mineral content 5 | 151
decreased circulating glucose ... 5 | 126
decreased lean body mass 5 | 135
decreased leukocyte cell numbe... 5 | 73
increased lean body mass 5 | 172
abnormal bone structure 4 | 187
abnormal epididymis morphology 4 | 42
decreased caudal vertebrae num... 4 | 53
decreased fasted circulating g... 4 | 65
decreased startle reflex 4 | 75
hypoactivity 4 | 132
increased circulating alkaline... 4 | 122
increased circulating triglyce... 4 | 42
increased heart weight 4 | 62
increased red blood cell distr... 4 | 34
increased total body fat amoun... 4 | 134
abnormal cornea morphology 3 | 31
abnormal cranium morphology 3 | 36
abnormal forebrain development 3 | 20
abnormal head morphology 3 | 10
abnormal hindbrain development 3 | 16
abnormal neural tube closure 3 | 46
abnormal retinal vasculature m... 3 | 27
abnormal skin morphology 3 | 50
abnormal sleep behavior 3 | 70
decreased body length 3 | 101
decreased body weight 3 | 161
decreased bone mineral density 3 | 126
decreased circulating choleste... 3 | 93
decreased circulating serum al... 3 | 82
decreased erythrocyte cell num... 3 | 62
decreased grip strength 3 | 116
decreased mean corpuscular hem... 3 | 50
embryonic growth retardation 3 | 106
enlarged epididymis 3 | 31
hyperactivity 3 | 148
impaired glucose tolerance 3 | 75
improved glucose tolerance 3 | 79
increased body length 3 | 32
increased bone mineral content 3 | 108
increased bone mineral density 3 | 72
increased circulating HDL chol... 3 | 80
increased circulating choleste... 3 | 66
increased circulating creatini... 3 | 38
increased fasted circulating g... 3 | 76
increased startle reflex 3 | 112
prenatal lethality prior to he... 3 | 87
short tibia 3 | 97
abnormal embryo turning 2 | 31
abnormal eye morphology 2 | 68
abnormal seminal vesicle morph... 2 | 114
abnormal spleen morphology 2 | 55
anophthalmia 2 | 33
decreased T cell number 2 | 15
decreased blood urea nitrogen ... 2 | 51
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating amylase ... 2 | 28
decreased circulating calcium ... 2 | 36
decreased circulating creatini... 2 | 39
decreased circulating fructosa... 2 | 30
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased circulating sodium l... 2 | 22
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
enlarged lymph nodes 2 | 37
enlarged spleen 2 | 41
increased circulating bilirubi... 2 | 16
increased circulating free fat... 2 | 20
increased circulating iron lev... 2 | 30
increased hemoglobin content 2 | 45
increased mean platelet volume 2 | 45
increased or absent threshold ... 2 | 101
increased prepulse inhibition 2 | 32
pale yolk sac 2 | 25
pallor 2 | 34
small superior vagus ganglion 2 | 74
vertebral fusion 2 | 23

Disease

Carcinoma 292 | 11,493
ovarian cancer 247 | 8,520
osteosarcoma 207 | 7,950
medulloblastoma, large-cell 188 | 6,241
glioblastoma 179 | 5,792
psoriasis 174 | 6,694
Cancer 157 | 2,499
atypical teratoid / rhabdoid tumor 155 | 5,112
lung cancer 153 | 4,740
group 3 medulloblastoma 131 | 4,104
ependymoma 129 | 4,679
adult high grade glioma 123 | 3,801
Breast cancer 121 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 111 | 3,291
malignant mesothelioma 106 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 95 | 2,989
oligodendroglioma 94 | 2,850
primitive neuroectodermal tumor 93 | 3,035
Astrocytoma, Pilocytic 92 | 3,081
non-small cell lung cancer 91 | 2,890
invasive ductal carcinoma 89 | 2,951
subependymal giant cell astrocytoma 82 | 2,287
Kidney cancer 81 | 2,613
lung adenocarcinoma 77 | 2,716
astrocytic glioma 73 | 2,597
diabetes mellitus 71 | 1,728
Pick disease 69 | 1,894
intraductal papillary-mucinous adenoma (IPMA) 66 | 2,955
breast carcinoma 65 | 1,638
pancreatic cancer 65 | 2,398
interstitial cystitis 63 | 2,312
lung carcinoma 63 | 2,843
tuberculosis 61 | 2,010
ductal carcinoma in situ 56 | 1,745
pituitary cancer 55 | 1,972
ulcerative colitis 54 | 1,819
group 4 medulloblastoma 52 | 1,855
Rheumatoid arthritis 51 | 1,191
Schizophrenia 50 | 1,160
adrenocortical carcinoma 50 | 1,428
colon cancer 50 | 1,478
astrocytoma 47 | 1,146
Multiple myeloma 46 | 1,332
pancreatic ductal adenocarcinoma liver metastasis 45 | 1,962
juvenile dermatomyositis 41 | 1,187
Epilepsy 38 | 792
acute quadriplegic myopathy 38 | 1,158
Autosomal recessive predisposition 37 | 1,442
Atopic dermatitis 36 | 952
cutaneous lupus erythematosus 36 | 1,057
Intellectual disability 35 | 1,016
Prostatic Neoplasms 34 | 495
pediatric high grade glioma 34 | 1,064
Breast Neoplasms 33 | 445
cystic fibrosis 33 | 1,696
spina bifida 33 | 1,074
Waldenstrons macroglobulinemia 32 | 765
nasopharyngeal carcinoma 31 | 1,058
Mammary Neoplasms 30 | 425
dermatomyositis 30 | 966
Melanoma 29 | 711
Endometriosis 28 | 540
acute myeloid leukemia 28 | 783
gastric carcinoma 28 | 807
Bipolar Disorder 27 | 666
Hypertension 27 | 396
Liver Cirrhosis, Experimental 27 | 769
primary pancreatic ductal adenocarcinoma 27 | 1,109
Alzheimer's disease 26 | 658
Stomach Neoplasms 25 | 300
esophageal adenocarcinoma 25 | 737
Carcinoma, Hepatocellular 24 | 228
Liver carcinoma 24 | 240
Neurodegenerative disease 24 | 414
Seizures 24 | 596
Obesity 23 | 678
Parkinson's disease 23 | 392
primary Sjogren syndrome 22 | 735
progressive supranuclear palsy 22 | 676
Hypertensive disease 21 | 292
active Crohn's disease 21 | 922
Crohn's disease 20 | 321
Duchenne muscular dystrophy 20 | 601
Dull intelligence 20 | 645
Liver cancer 20 | 604
Low intelligence 20 | 645
Lung Neoplasms 20 | 232
Mental Retardation 20 | 645
Mental deficiency 20 | 645
Poor school performance 20 | 645
Amyotrophic lateral sclerosis 19 | 451
Cognitive delay 19 | 608
Depressive disorder 19 | 409
Global developmental delay 19 | 608
Mental and motor retardation 19 | 608
Vascular disease 19 | 319
medulloblastoma 19 | 720
Chronic Lymphocytic Leukemia 18 | 262
Muscle hypotonia 18 | 571
Polycystic ovary syndrome 18 | 360

Tissue

Endocrine System 403 | 18,159
Digestive Tract 401 | 17,369
Female tissues 399 | 17,400
Male tissues 399 | 17,142
Skin and soft tissues 398 | 17,230
Blood and immune system 397 | 16,909
Liver and Pancreas 395 | 16,750
Respiratory system 392 | 16,393
Urinary Tract 391 | 16,678
Nervous System 386 | 16,725
Cardiovascular System 377 | 15,192

Target Family

Non-IDG 229 | 12,091
Enzyme 74 | 4,145
Kinase 56 | 634
Transcription Factor 28 | 1,400
Transporter 8 | 473
Ion Channel 5 | 344
GPCR 4 | 408
Epigenetic 3 | 242
Nuclear Receptor 3 | 48

GO Function

protein kinase binding 410 | 410
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
CDK2-associated and cullin domain-containing protein 1 CACUL1 Tbio Non-IDG -0.58734 5.65 98
Solute carrier family 12 member 7 SLC12A7 Tbio Transporter -1.46102 28.2 156
Moesin MSN Tbio Non-IDG -2.61389 361.7 550
PML-RARA-regulated adapter molecule 1 PRAM1 Tbio Non-IDG -2.18597 152.1 104
Serine/threonine-protein kinase VRK2 VRK2 Tbio Kinase -1.28897 20.5 123
Centlein CNTLN Tbio Non-IDG -2.28518 122.3 76
Putative speedy protein E7 SPDYE7P Tdark Non-IDG 0.00000 0
Speedy protein E2 SPDYE2 Tdark Non-IDG 0.00000 3
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440