Development Level

Tchem 127 | 1,598
Tbio 35 | 11,445
Tclin 14 | 613
Tdark 6 | 6,588

Collection

Kinase: IDG Consortium (Target... 24 | 125
Kinase: IDG Consortium (Comple... 10 | 37

IMPC Phenotype

preweaning lethality, complete... 18 | 979
embryonic lethality prior to t... 10 | 278
preweaning lethality, incomple... 8 | 499
embryonic lethality prior to o... 7 | 239
abnormal bone structure 5 | 187
abnormal embryo size 4 | 220
decreased fasted circulating g... 4 | 65
increased or absent threshold ... 4 | 101
abnormal behavior 3 | 298
abnormal heart morphology 3 | 162
abnormal lens morphology 3 | 81
decreased blood urea nitrogen ... 3 | 51
decreased bone mineral content 3 | 151
decreased large unstained cell... 3 | 11
decreased leukocyte cell numbe... 3 | 73
decreased neutrophil cell numb... 3 | 42
increased circulating alkaline... 3 | 122
increased mean platelet volume 3 | 45
increased startle reflex 3 | 112
increased total body fat amoun... 3 | 134
abnormal embryo turning 2 | 31
abnormal response to new envir... 2 | 10
abnormal retina morphology 2 | 71
abnormal skin morphology 2 | 50
abnormal spleen morphology 2 | 55
abnormal testis morphology 2 | 43
cataract 2 | 92
decreased circulating LDL chol... 2 | 38
decreased circulating iron lev... 2 | 32
decreased hematocrit 2 | 46
decreased lymphocyte cell numb... 2 | 83
decreased mean platelet volume 2 | 25
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
enlarged spleen 2 | 41
impaired glucose tolerance 2 | 75
impaired righting response 2 | 26
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased circulating iron lev... 2 | 30
increased mean corpuscular hem... 2 | 96
small testis 2 | 58
abnormal behavioral response t... 1 | 66
abnormal cranium morphology 1 | 36
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal pelvic girdle bone mo... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
absent vibrissae 1 | 12
anophthalmia 1 | 33
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased startle reflex 1 | 75
edema 1 | 59
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
enlarged thymus 1 | 5
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased heart rate 1 | 23
increased heart weight 1 | 62
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
male infertility 1 | 123
shortened RR interval 1 | 17
thin ventricular wall 1 | 24

Disease

Carcinoma 157 | 11,493
ovarian cancer 116 | 8,520
osteosarcoma 100 | 7,950
medulloblastoma, large-cell 85 | 6,241
psoriasis 82 | 6,694
glioblastoma 71 | 5,792
Cancer 70 | 2,499
lung cancer 70 | 4,740
atypical teratoid / rhabdoid tumor 66 | 5,112
Kidney cancer 64 | 2,613
ependymoma 57 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 56 | 3,291
group 3 medulloblastoma 52 | 4,104
Breast cancer 49 | 3,578
malignant mesothelioma 49 | 3,232
non-small cell lung cancer 45 | 2,890
adult high grade glioma 44 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 44 | 2,989
oligodendroglioma 44 | 2,850
invasive ductal carcinoma 43 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 38 | 2,955
lung adenocarcinoma 37 | 2,716
primitive neuroectodermal tumor 34 | 3,035
Astrocytoma, Pilocytic 33 | 3,081
pancreatic cancer 33 | 2,398
astrocytic glioma 31 | 2,597
lung carcinoma 31 | 2,843
Pick disease 29 | 1,894
tuberculosis 29 | 2,010
group 4 medulloblastoma 27 | 1,855
ulcerative colitis 27 | 1,819
diabetes mellitus 26 | 1,728
interstitial cystitis 26 | 2,312
subependymal giant cell astrocytoma 26 | 2,287
adrenocortical carcinoma 24 | 1,428
Autosomal recessive predisposition 23 | 1,442
Renal Cell Carcinoma 23 | 214
cystic fibrosis 23 | 1,696
juvenile dermatomyositis 23 | 1,187
Schizophrenia 22 | 1,160
astrocytoma 22 | 1,146
breast carcinoma 22 | 1,638
colon cancer 22 | 1,478
Intellectual disability 21 | 1,016
acute quadriplegic myopathy 21 | 1,158
ductal carcinoma in situ 21 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
pituitary cancer 18 | 1,972
Dull intelligence 17 | 645
Low intelligence 17 | 645
Mental Retardation 17 | 645
Mental deficiency 17 | 645
Poor school performance 17 | 645
Rheumatoid arthritis 17 | 1,191
spina bifida 16 | 1,074
Hypertension 15 | 396
nasopharyngeal carcinoma 15 | 1,058
pediatric high grade glioma 15 | 1,064
Atopic dermatitis 14 | 952
Gastrointestinal stromal tumor 14 | 62
Multiple myeloma 14 | 1,332
primary pancreatic ductal adenocarcinoma 14 | 1,109
Alzheimer's disease 13 | 658
Blastic phase chronic myeloid leukemia 13 | 58
Chronic Myelocytic Leukemia Accelerated Phase 13 | 59
Endometriosis 13 | 540
Hypertensive disease 13 | 292
Obesity 13 | 678
cutaneous lupus erythematosus 13 | 1,057
primary Sjogren syndrome 13 | 735
Acquired scoliosis 12 | 281
Cognitive delay 12 | 608
Curvature of spine 12 | 282
Epilepsy 12 | 792
Global developmental delay 12 | 608
Hypoplastic mandible condyle 12 | 275
Mandibular hypoplasia 12 | 275
Mental and motor retardation 12 | 608
Micrognathism 12 | 275
Muscle hypotonia 12 | 571
Orbital separation excessive 12 | 244
Prostatic Neoplasms 12 | 495
Short stature 12 | 531
active Crohn's disease 12 | 922
dermatomyositis 12 | 966
Bipolar Disorder 11 | 666
Breast Neoplasms 11 | 445
Mammary Neoplasms 11 | 425
Pancreatic Neuroendocrine Tumor 11 | 45
Parkinson's disease 11 | 392
Seizures 11 | 596
Small head 11 | 374
Vascular disease 11 | 319
progressive supranuclear palsy 11 | 676
Depressed nasal bridge 10 | 195
Depressive disorder 10 | 409
Down syndrome 10 | 499
Glaucoma 10 | 239
Waldenstrons macroglobulinemia 10 | 765
esophageal adenocarcinoma 10 | 737

Tissue

Endocrine System 180 | 18,159
Digestive Tract 177 | 17,369
Male tissues 177 | 17,142
Skin and soft tissues 177 | 17,230
Blood and immune system 176 | 16,909
Female tissues 176 | 17,400
Nervous System 175 | 16,725
Liver and Pancreas 174 | 16,750
Respiratory system 174 | 16,393
Urinary Tract 174 | 16,678
Cardiovascular System 168 | 15,192

Target Family

Kinase 163 | 634
Non-IDG 11 | 12,091
Enzyme 6 | 4,145
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

GO Function

protein kinase activity 182 | 182
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase MRCK beta CDC42BPB Tbio Kinase -0.59618 3.72 111
Inactive serine/threonine-protein kinase PLK5 PLK5 Tbio Kinase -0.60609 4.07 119
Ribosomal protein S6 kinase alpha-6 RPS6KA6 Tchem Kinase -1.26563 21.6 158
Serine/threonine-protein kinase SMG1 SMG1 Tchem Kinase -1.61615 60.9 195
Serine/threonine-protein kinase 24 STK24 Tchem Kinase -2.24110 132.9 243
Dual specificity tyrosine-phosphorylation-regulated kinase 1A DYRK1A Tchem Kinase -2.68760 506.6 336
Serine/threonine-protein kinase PRP4 homolog PRPF4B Tchem Kinase -1.17233 14.7 144
Retinal guanylyl cyclase 1 GUCY2D Tbio Kinase -2.20658 167.7 205
Mitogen-activated protein kinase kinase kinase kinase 5 MAP4K5 Tchem Kinase -1.76819 60.5 0
Dual specificity tyrosine-phosphorylation-regulated kinase 1B DYRK1B Tchem Kinase -1.63295 52.7 289