Development Level

Tbio 9 | 11,651
Tclin 4 | 612
Tchem 1 | 1,388

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased lean body mass 1 | 135
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
increased heart rate 1 | 23
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134

Disease

Carcinoma 11 | 11,493
ovarian cancer 10 | 8,520
atypical teratoid / rhabdoid tumor 8 | 5,112
medulloblastoma, large-cell 8 | 6,241
osteosarcoma 8 | 7,950
ependymoma 7 | 4,679
glioblastoma 7 | 5,792
Breast cancer 6 | 3,578
adult high grade glioma 6 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
oligodendroglioma 6 | 2,850
psoriasis 6 | 6,694
tuberculosis 6 | 2,010
astrocytic glioma 5 | 2,597
diabetes mellitus 5 | 1,728
group 3 medulloblastoma 5 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
lung cancer 5 | 4,740
malignant mesothelioma 5 | 3,232
pancreatic cancer 5 | 2,398
Astrocytoma, Pilocytic 4 | 3,081
Cancer 4 | 2,499
Carney complex 4 | 25
Osteoarthritis 4 | 184
Pick disease 4 | 1,894
acute quadriplegic myopathy 4 | 1,158
lung adenocarcinoma 4 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
subependymal giant cell astrocytoma 4 | 2,287
Alzheimer's disease 3 | 658
Amyotrophic lateral sclerosis 3 | 451
Cryptorchidism 3 | 296
Depressive disorder 3 | 409
Familial atrial fibrillation 3 | 23
Heart failure 3 | 162
Kidney cancer 3 | 2,613
Parkinson's disease 3 | 392
Primary pigmented nodular adrenocortical disease 3 | 13
Rheumatoid arthritis 3 | 1,191
active Crohn's disease 3 | 922
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696
ductal carcinoma in situ 3 | 1,745
group 4 medulloblastoma 3 | 1,855
hereditary spastic paraplegia 3 | 318
pancreatic carcinoma 3 | 562
primitive neuroectodermal tumor 3 | 3,035
Acquired scoliosis 2 | 281
Advanced bone age 2 | 35
Animal Mammary Neoplasms 2 | 136
Autism spectrum disorder 2 | 101
Autosomal recessive predisposition 2 | 1,442
Bipolar Disorder 2 | 666
Bipolar affective disorder, current episode manic 2 | 13
Bipolar disorder in remission 2 | 19
Cardiac Arrhythmia 2 | 103
Cardiomegaly 2 | 116
Cardiomyopathy 2 | 116
Concave bridge of nose 2 | 195
Congenital deafness 2 | 185
Curvature of spine 2 | 282
Deafness 2 | 198
Depressed nasal bridge 2 | 195
Depressed nasal ridge 2 | 51
Depressed nasal root/bridge 2 | 195
Down syndrome 2 | 499
Duchenne muscular dystrophy 2 | 601
Epilepsy 2 | 792
Exophthalmos 2 | 112
Fever 2 | 138
Gonadoblastoma 2 | 34
Hearing Loss, Partial 2 | 185
Heart disease 2 | 306
Hypogonadism 2 | 173
Major Depressive Disorder 2 | 301
Mammary Neoplasms, Animal 2 | 136
Mammary Neoplasms, Experimental 2 | 154
Myocardial Infarction 2 | 151
Osteoporosis 2 | 363
Penile hypospadias 2 | 106
Polycystic ovary syndrome 2 | 360
Prominent eyes 2 | 96
Prominent globes 2 | 96
Prostatic Neoplasms 2 | 495
Protruding eyes 2 | 96
Schizophrenia 2 | 1,160
Short limb dwarfism, disproportionate 2 | 22
Short stature 2 | 531
Tachycardia 2 | 43
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
esophageal adenocarcinoma 2 | 737
gastric cancer 2 | 459
hearing impairment 2 | 199
interstitial cystitis 2 | 2,312
invasive ductal carcinoma 2 | 2,951
juvenile dermatomyositis 2 | 1,187
pituitary cancer 2 | 1,972
sarcoidosis 2 | 370
ulcerative colitis 2 | 1,819

Tissue

Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678

Target Family

Enzyme 7 | 4,145
Kinase 3 | 634
Ion Channel 2 | 344
Non-IDG 1 | 12,091
Transcription Factor 1 | 1,400

GO Function

protein kinase A catalytic sub... 14 | 14
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ezrin EZR Tbio Non-IDG -2.99865 981.3 1088
Tyrosine-protein kinase CSK CSK Tchem Kinase -2.54736 271.3 547
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -3.00390 610.8 955
Glycogen synthase kinase-3 alpha GSK3A Tclin Kinase -1.82880 53.1 840
cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A Tbio Enzyme -2.37476 257.4 258
Transcription factor SOX-9 SOX9 Tbio Transcription Factor -3.14522 1332.4 657
Ryanodine receptor 2 RYR2 Tclin Ion Channel -2.92980 851.9 138
cAMP-dependent protein kinase inhibitor alpha PKIA Tbio Enzyme -1.27058 17.1 34
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.90675 800.2 365
Ras-related protein Rab-13 RAB13 Tbio Enzyme -1.40524 27.4 73