Development Level

Tbio 577 | 11,445
Tchem 147 | 1,598
Tclin 56 | 613
Tdark 21 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 49 | 979
preweaning lethality, incomple... 29 | 499
abnormal behavior 16 | 298
decreased circulating glucose ... 12 | 126
abnormal embryo size 11 | 220
decreased body weight 11 | 161
decreased total body fat amoun... 11 | 207
increased lean body mass 11 | 172
embryonic lethality prior to o... 10 | 239
enlarged heart 10 | 210
embryonic lethality prior to t... 9 | 278
hyperactivity 9 | 148
abnormal heart morphology 8 | 162
decreased fasted circulating g... 8 | 65
decreased grip strength 8 | 116
decreased vertical activity 8 | 208
increased startle reflex 8 | 112
abnormal bone structure 7 | 187
cataract 7 | 92
increased total body fat amoun... 7 | 134
abnormal lens morphology 6 | 81
abnormal retina morphology 6 | 71
abnormal retinal vasculature m... 6 | 27
hypoactivity 6 | 132
male infertility 6 | 123
abnormal eye morphology 5 | 68
decreased body length 5 | 101
decreased bone mineral content 5 | 151
decreased bone mineral density 5 | 126
decreased circulating choleste... 5 | 93
decreased hemoglobin content 5 | 68
decreased lymphocyte cell numb... 5 | 83
decreased prepulse inhibition 5 | 82
increased blood urea nitrogen ... 5 | 48
increased bone mineral density 5 | 72
increased circulating alkaline... 5 | 122
increased circulating sodium l... 5 | 71
increased grip strength 5 | 41
increased heart weight 5 | 62
persistence of hyaloid vascula... 5 | 33
thrombocytopenia 5 | 56
abnormal cranium morphology 4 | 36
decreased circulating triglyce... 4 | 79
decreased startle reflex 4 | 75
increased circulating choleste... 4 | 66
increased circulating triglyce... 4 | 42
increased fasted circulating g... 4 | 76
abnormal craniofacial morpholo... 3 | 33
abnormal retinal blood vessel ... 3 | 26
abnormal sleep behavior 3 | 70
abnormal tooth morphology 3 | 24
cardiovascular system phenotyp... 3 | 36
decreased blood urea nitrogen ... 3 | 51
decreased caudal vertebrae num... 3 | 53
decreased circulating glycerol... 3 | 16
decreased circulating sodium l... 3 | 22
decreased erythrocyte cell num... 3 | 62
decreased hematocrit 3 | 46
decreased lean body mass 3 | 135
decreased leukocyte cell numbe... 3 | 73
decreased mean corpuscular hem... 3 | 50
decreased mean corpuscular vol... 3 | 79
edema 3 | 59
embryonic growth retardation 3 | 106
enlarged lymph nodes 3 | 37
female infertility 3 | 60
impaired righting response 3 | 26
improved glucose tolerance 3 | 79
increased body length 3 | 32
increased circulating HDL chol... 3 | 80
increased circulating amylase ... 3 | 25
increased circulating free fat... 3 | 20
increased hemoglobin content 3 | 45
increased mean corpuscular hem... 3 | 96
pale yolk sac 3 | 25
prolonged QT interval 3 | 38
small superior vagus ganglion 3 | 74
tremors 3 | 39
abnormal coat-hair pigmentatio... 2 | 64
abnormal epididymis morphology 2 | 42
abnormal gait 2 | 69
abnormal lung morphology 2 | 26
abnormal seminal vesicle morph... 2 | 114
abnormal spleen morphology 2 | 55
abnormal vibrissa morphology 2 | 25
absent startle reflex 2 | 24
anophthalmia 2 | 33
decreased circulating HDL chol... 2 | 68
decreased circulating calcium ... 2 | 36
decreased circulating iron lev... 2 | 32
decreased circulating serum al... 2 | 82
decreased neutrophil cell numb... 2 | 42
increased circulating aspartat... 2 | 15
increased circulating bilirubi... 2 | 16
increased circulating total pr... 2 | 28
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
microphthalmia 2 | 26
pallor 2 | 34
prenatal lethality prior to he... 2 | 87

Disease

Carcinoma 491 | 11,493
ovarian cancer 442 | 8,520
osteosarcoma 393 | 7,950
psoriasis 368 | 6,694
glioblastoma 325 | 5,792
lung cancer 318 | 4,740
medulloblastoma, large-cell 311 | 6,241
Cancer 248 | 2,499
atypical teratoid / rhabdoid tumor 241 | 5,112
ependymoma 233 | 4,679
Breast cancer 206 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 200 | 3,291
invasive ductal carcinoma 200 | 2,951
group 3 medulloblastoma 190 | 4,104
adult high grade glioma 187 | 3,801
malignant mesothelioma 187 | 3,232
lung carcinoma 180 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 177 | 2,989
non-small cell lung cancer 173 | 2,890
Astrocytoma, Pilocytic 167 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 165 | 2,955
lung adenocarcinoma 157 | 2,716
pancreatic cancer 157 | 2,398
oligodendroglioma 148 | 2,850
subependymal giant cell astrocytoma 145 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 143 | 1,962
primitive neuroectodermal tumor 140 | 3,035
Autosomal recessive predisposition 137 | 1,442
interstitial cystitis 132 | 2,312
Kidney cancer 130 | 2,613
ulcerative colitis 129 | 1,819
astrocytic glioma 124 | 2,597
breast carcinoma 118 | 1,638
tuberculosis 116 | 2,010
ductal carcinoma in situ 115 | 1,745
pituitary cancer 114 | 1,972
diabetes mellitus 104 | 1,728
Pick disease 100 | 1,894
group 4 medulloblastoma 100 | 1,855
cystic fibrosis 99 | 1,696
adrenocortical carcinoma 97 | 1,428
colon cancer 96 | 1,478
Schizophrenia 92 | 1,160
Multiple myeloma 91 | 1,332
acute quadriplegic myopathy 80 | 1,158
cutaneous lupus erythematosus 79 | 1,057
astrocytoma 75 | 1,146
pediatric high grade glioma 72 | 1,064
Epilepsy 71 | 792
Intellectual disability 68 | 1,016
Liver Cirrhosis, Experimental 68 | 769
dermatomyositis 67 | 966
Seizures 65 | 596
Bipolar Disorder 64 | 666
Rheumatoid arthritis 64 | 1,191
Waldenstrons macroglobulinemia 63 | 765
nasopharyngeal carcinoma 63 | 1,058
juvenile dermatomyositis 61 | 1,187
esophageal adenocarcinoma 60 | 737
Atopic dermatitis 58 | 952
Obesity 58 | 678
primary pancreatic ductal adenocarcinoma 58 | 1,109
Breast Neoplasms 57 | 445
Mammary Neoplasms 55 | 425
acute myeloid leukemia 53 | 783
active Crohn's disease 52 | 922
aldosterone-producing adenoma 52 | 665
gastric carcinoma 52 | 807
spina bifida 52 | 1,074
Alzheimer's disease 51 | 658
Dull intelligence 50 | 645
Kidney disease 50 | 430
Low intelligence 50 | 645
Mental Retardation 50 | 645
Mental deficiency 50 | 645
Poor school performance 50 | 645
Prostatic Neoplasms 50 | 495
Depressive disorder 49 | 409
non primary Sjogren syndrome sicca 49 | 891
Cognitive delay 48 | 608
Global developmental delay 48 | 608
Hypertension 48 | 396
Mental and motor retardation 48 | 608
Neurodegenerative disease 48 | 414
fibroadenoma 48 | 559
active ulcerative colitis 45 | 764
primary Sjogren syndrome 45 | 735
Down syndrome 44 | 499
Melanoma 44 | 711
Short stature 44 | 531
progressive supranuclear palsy 43 | 676
Anemia 40 | 365
Asthma 40 | 385
Atherosclerosis 39 | 291
Osteoporosis 39 | 363
Parkinson's disease 39 | 392
Amyotrophic lateral sclerosis 38 | 451
Vascular disease 38 | 319
Muscle hypotonia 37 | 571
gastric cancer 37 | 459

Tissue

Endocrine System 781 | 18,159
Digestive Tract 778 | 17,369
Skin and soft tissues 774 | 17,230
Female tissues 771 | 17,400
Liver and Pancreas 766 | 16,750
Male tissues 765 | 17,142
Urinary Tract 765 | 16,678
Blood and immune system 758 | 16,909
Nervous System 751 | 16,725
Respiratory system 742 | 16,393
Cardiovascular System 711 | 15,192

Target Family

Non-IDG 363 | 12,091
Enzyme 215 | 4,145
Transcription Factor 92 | 1,400
Kinase 59 | 634
Transporter 23 | 473
Ion Channel 16 | 344
GPCR 12 | 408
Epigenetic 10 | 242
Nuclear Receptor 8 | 48
TF/Epigenetic 3 | 38

GO Function

protein homodimerization activ... 801 | 801
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
B-cell antigen receptor complex-associated protein alpha chain CD79A Tbio Non-IDG -4.45149 28259.4 1170
RAC-alpha serine/threonine-protein kinase AKT1 Tchem Kinase -4.36734 20160.1 3565
Vascular endothelial growth factor A VEGFA Tclin Non-IDG -4.27197 19076.6 1809
Apolipoprotein E APOE Tbio Non-IDG -4.20176 15904.9 976
Prostaglandin G/H synthase 2 PTGS2 Tclin Enzyme -4.06834 12504.5 731
Amyloid-beta A4 protein APP Tchem Non-IDG -3.99225 9853.3 2781