Development Level

Tbio 408 | 10,625
Tchem 115 | 1,890
Tclin 30 | 602
Tdark 16 | 7,003

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 25 | 633
preweaning lethality, incomple... 10 | 260
decreased body weight 8 | 174
abnormal embryo size 6 | 112
abnormal retina morphology 6 | 100
decreased grip strength 6 | 123
decreased lean body mass 6 | 195
increased grip strength 6 | 83
abnormal behavior 5 | 226
decreased total body fat amoun... 5 | 186
increased lean body mass 5 | 107
abnormal eye size 4 | 11
abnormal lens morphology 4 | 73
abnormal retinal pigmentation 4 | 61
decreased caudal vertebrae num... 4 | 49
decreased circulating glucose ... 4 | 121
decreased prepulse inhibition 4 | 52
hydrops fetalis 4 | 22
hypoactivity 4 | 89
increased circulating HDL chol... 4 | 63
increased circulating choleste... 4 | 53
abnormal bone mineralization 3 | 55
abnormal eye morphology 3 | 38
abnormal retinal vasculature m... 3 | 15
decreased bone mineral content 3 | 157
decreased bone mineral density 3 | 126
decreased circulating alanine ... 3 | 53
decreased circulating calcium ... 3 | 33
decreased circulating choleste... 3 | 85
decreased circulating glycerol... 3 | 19
decreased circulating triglyce... 3 | 83
decreased fasted circulating g... 3 | 49
decreased hemoglobin content 3 | 53
embryonic lethality prior to o... 3 | 148
embryonic lethality prior to t... 3 | 187
increased bone mineral content 3 | 92
increased circulating alkaline... 3 | 119
increased circulating sodium l... 3 | 71
increased hemoglobin content 3 | 45
increased mean corpuscular hem... 3 | 93
increased respiratory quotient 3 | 12
increased rib number 3 | 41
microphthalmia 3 | 15
persistence of hyaloid vascula... 3 | 22
thrombocytopenia 3 | 46
abnormal bone structure 2 | 131
abnormal coat appearance 2 | 25
abnormal cranium morphology 2 | 32
abnormal epididymis morphology 2 | 31
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal skin appearance 2 | 8
abnormal tooth morphology 2 | 24
abnormal vibrissa morphology 2 | 17
anophthalmia 2 | 20
cataract 2 | 26
craniofacial phenotype 2 | 9
decreased blood urea nitrogen ... 2 | 31
decreased circulating HDL chol... 2 | 77
decreased circulating alkaline... 2 | 41
decreased lymphocyte cell numb... 2 | 9
decreased monocyte cell number 2 | 28
decreased neutrophil cell numb... 2 | 37
decreased startle reflex 2 | 48
enlarged heart 2 | 111
enlarged lymph nodes 2 | 27
female infertility 2 | 34
hyperactivity 2 | 108
immune system phenotype 2 | 17
increased NK cell number 2 | 19
increased blood urea nitrogen ... 2 | 44
increased bone mineral density 2 | 52
increased circulating amylase ... 2 | 13
increased circulating aspartat... 2 | 17
increased circulating bilirubi... 2 | 16
increased circulating total pr... 2 | 20
increased circulating triglyce... 2 | 24
increased effector memory CD8-... 2 | 14
increased exploration in new e... 2 | 56
increased fasted circulating g... 2 | 68
increased heart weight 2 | 37
increased mean corpuscular vol... 2 | 91
increased neutrophil cell numb... 2 | 15
increased startle reflex 2 | 38
increased total body fat amoun... 2 | 57
limb grasping 2 | 35
pale yolk sac 2 | 12
polycystic kidney 2 | 9
prenatal lethality 2 | 16
small adrenal glands 2 | 15
tremors 2 | 34
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal neural tube morpholog... 1 | 8
decreased mean corpuscular hem... 1 | 34
increased circulating magnesiu... 1 | 10
increased sacral vertebrae num... 1 | 62
long tibia 1 | 13

Disease

ovarian cancer 314 | 8,484
osteosarcoma 282 | 7,933
psoriasis 259 | 6,685
glioblastoma 228 | 5,572
medulloblastoma, large-cell 227 | 6,234
lung cancer 217 | 4,466
Cancer 177 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 154 | 3,289
invasive ductal carcinoma 149 | 2,950
atypical teratoid / rhabdoid tumor 147 | 4,369
Breast cancer 128 | 3,094
lung carcinoma 127 | 2,844
malignant mesothelioma 127 | 3,162
non-small cell lung cancer 122 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 121 | 2,988
pediatric high grade glioma 120 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 118 | 2,956
pilocytic astrocytoma 118 | 3,086
lung adenocarcinoma 110 | 2,713
oligodendroglioma 110 | 2,849
primitive neuroectodermal tumor 108 | 3,031
ulcerative colitis 105 | 2,087
pancreatic cancer 100 | 2,300
subependymal giant cell astrocytoma 94 | 2,287
interstitial cystitis 90 | 2,299
ductal carcinoma in situ 89 | 1,745
breast carcinoma 85 | 1,614
ependymoma 84 | 2,514
pancreatic ductal adenocarcinoma liver metastasis 82 | 1,795
Carcinoma 81 | 2,147
pituitary cancer 80 | 1,972
astrocytic glioma 77 | 2,241
group 3 medulloblastoma 73 | 2,254
Pick disease 72 | 1,893
colon cancer 71 | 1,475
diabetes mellitus 69 | 1,663
Multiple myeloma 68 | 1,327
adult high grade glioma 68 | 2,148
tuberculosis 68 | 1,557
group 4 medulloblastoma 67 | 1,875
adrenocortical carcinoma 65 | 1,427
astrocytoma 65 | 1,493
cystic fibrosis 65 | 1,665
posterior fossa group A ependymoma 65 | 1,511
sonic hedgehog group medulloblastoma 63 | 1,482
cutaneous lupus erythematosus 58 | 1,056
acute quadriplegic myopathy 51 | 1,157
primary pancreatic ductal adenocarcinoma 50 | 1,271
dermatomyositis 49 | 933
Rheumatoid Arthritis 47 | 1,160
Waldenstrons macroglobulinemia 46 | 765
juvenile dermatomyositis 45 | 1,189
nasopharyngeal carcinoma 45 | 1,056
esophageal adenocarcinoma 44 | 737
medulloblastoma 44 | 1,524
Mammary Neoplasms 42 | 410
atypical teratoid/rhabdoid tumor 42 | 1,095
posterior fossa group B ependymoma 41 | 1,530
gastric carcinoma 39 | 832
Atopic dermatitis 38 | 944
aldosterone-producing adenoma 38 | 664
Alzheimer's disease 37 | 644
Obesity 37 | 616
active Crohn's disease 36 | 918
primary Sjogren syndrome 36 | 789
acute myeloid leukemia 35 | 780
spina bifida 35 | 1,064
fibroadenoma 34 | 557
Prostatic Neoplasms 33 | 471
Kidney disease 30 | 396
Neurodegenerative disease 30 | 383
non primary Sjogren syndrome sicca 30 | 840
progressive supranuclear palsy 30 | 674
Duchenne muscular dystrophy 27 | 602
Endometriosis 27 | 535
mucosa-associated lymphoid tissue lymphoma 27 | 480
Amyotrophic Lateral Sclerosis 26 | 431
Asthma 26 | 349
Atherosclerosis 26 | 275
Down syndrome 26 | 548
IGA Glomerulonephritis 26 | 454
Intellectual disability 26 | 573
Schizophrenia 26 | 501
Parkinson's disease 25 | 364
Autistic Disorder 23 | 320
Multiple Sclerosis 23 | 498
Polycystic Ovary Syndrome 23 | 332
inflammatory breast cancer 23 | 404
gastric cancer 22 | 430
sarcoidosis 22 | 358
Coronary artery disease 21 | 240
Diabetes Mellitus, Non-Insulin-Dependent 21 | 157
Lung Neoplasms 21 | 171
Renal Cell Carcinoma 21 | 199
Vascular disease 21 | 281
chronic rhinosinusitis 21 | 512
non-small cell lung carcinoma 21 | 413
Colorectal Neoplasms 20 | 217
pancreatic carcinoma 20 | 567
tuberculosis and treatment for 6 months 20 | 686

Tissue

Digestive Tract 565 | 18,473
Liver and Pancreas 564 | 18,136
Urinary Tract 564 | 18,444
Blood and immune system 562 | 17,995
Female tissues 562 | 18,647
Nervous System 561 | 18,561
Endocrine System 559 | 18,512
Cardiovascular System 556 | 17,958
Male tissues 555 | 17,969
Skin and soft tissues 554 | 18,115
Respiratory system 549 | 17,484

Target Family

Non-IDG 252 | 11,971
Enzyme 161 | 4,146
Transcription Factor 59 | 1,400
Kinase 51 | 634
Transporter 15 | 473
GPCR 8 | 406
Ion Channel 8 | 341
Nuclear Receptor 7 | 48
Epigenetic 6 | 242
TF/Epigenetic 2 | 38

GO Function

protein homodimerization activ... 569 | 569
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
Ropporin-1B ROPN1B Tbio Non-IDG 1.00 0.10 52
Transcription factor E2-alpha TCF3 Tbio Transcription Factor -2.76637 577.9 373
Angiogenin ANG Tbio Enzyme -2.89794 796.0 203
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 AIMP1 Tbio Enzyme -2.04569 136.6 321