Development Level

Tbio 334 | 11,445
Tchem 69 | 1,598
Tclin 42 | 613
Tdark 28 | 6,588

Collection

RFA-RM-18-021 2 | 328
Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 27 | 979
preweaning lethality, incomple... 14 | 499
embryonic lethality prior to t... 10 | 278
abnormal behavior 8 | 298
embryonic lethality prior to o... 8 | 239
decreased total body fat amoun... 7 | 207
abnormal embryo size 6 | 220
decreased vertical activity 6 | 208
hyperactivity 6 | 148
increased lean body mass 6 | 172
increased mean corpuscular vol... 6 | 92
increased startle reflex 6 | 112
abnormal retina morphology 5 | 71
decreased fasted circulating g... 5 | 65
abnormal lens morphology 4 | 81
abnormal tooth morphology 4 | 24
decreased body weight 4 | 161
decreased bone mineral density 4 | 126
decreased lean body mass 4 | 135
decreased leukocyte cell numbe... 4 | 73
decreased lymphocyte cell numb... 4 | 83
increased bone mineral content 4 | 108
increased bone mineral density 4 | 72
increased total body fat amoun... 4 | 134
male infertility 4 | 123
prenatal lethality prior to he... 4 | 87
abnormal kidney morphology 3 | 65
cataract 3 | 92
decreased bone mineral content 3 | 151
decreased circulating amylase ... 3 | 28
decreased circulating choleste... 3 | 93
decreased circulating insulin ... 3 | 76
decreased circulating triglyce... 3 | 79
decreased hemoglobin content 3 | 68
embryonic growth retardation 3 | 106
enlarged spleen 3 | 41
increased grip strength 3 | 41
increased mean corpuscular hem... 3 | 96
long tibia 3 | 25
vertebral fusion 3 | 23
abnormal behavioral response t... 2 | 66
abnormal bone mineralization 2 | 38
abnormal bone structure 2 | 187
abnormal cranium morphology 2 | 36
abnormal embryo turning 2 | 31
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal seminal vesicle morph... 2 | 114
abnormal spleen morphology 2 | 55
abnormal vertebrae morphology 2 | 18
decreased IgG1 level 2 | 8
decreased blood urea nitrogen ... 2 | 51
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating alanine ... 2 | 47
decreased circulating chloride... 2 | 30
decreased circulating glucose ... 2 | 126
decreased circulating potassiu... 2 | 20
decreased erythrocyte cell num... 2 | 62
decreased hematocrit 2 | 46
decreased mean corpuscular hem... 2 | 31
decreased prepulse inhibition 2 | 82
enlarged heart 2 | 210
enlarged testis 2 | 6
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased circulating potassiu... 2 | 29
increased circulating triglyce... 2 | 42
increased erythrocyte cell num... 2 | 39
increased neutrophil cell numb... 2 | 46
increased red blood cell distr... 2 | 34
microphthalmia 2 | 26
persistence of hyaloid vascula... 2 | 33
polycystic kidney 2 | 15
small superior vagus ganglion 2 | 74
abnormal craniofacial morpholo... 1 | 33
abnormal ear morphology 1 | 9
abnormal neural tube closure 1 | 46
convulsive seizures 1 | 13
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased circulating creatine... 1 | 4
decreased circulating magnesiu... 1 | 13
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating creatine... 1 | 5
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
prenatal lethality 1 | 28
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Carcinoma 291 | 11,493
ovarian cancer 248 | 8,520
osteosarcoma 207 | 7,950
psoriasis 207 | 6,694
glioblastoma 185 | 5,792
lung cancer 178 | 4,740
medulloblastoma, large-cell 170 | 6,241
atypical teratoid / rhabdoid tumor 154 | 5,112
Cancer 142 | 2,499
ependymoma 138 | 4,679
Breast cancer 128 | 3,578
group 3 medulloblastoma 121 | 4,104
invasive ductal carcinoma 116 | 2,951
malignant mesothelioma 114 | 3,232
adult high grade glioma 112 | 3,801
lung adenocarcinoma 100 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 97 | 2,989
non-small cell lung cancer 97 | 2,890
Astrocytoma, Pilocytic 96 | 3,081
lung carcinoma 95 | 2,843
oligodendroglioma 94 | 2,850
intraductal papillary-mucinous neoplasm (IPMN) 92 | 3,291
pancreatic cancer 92 | 2,398
primitive neuroectodermal tumor 89 | 3,035
diabetes mellitus 80 | 1,728
astrocytic glioma 79 | 2,597
breast carcinoma 79 | 1,638
ductal carcinoma in situ 78 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 75 | 2,955
tuberculosis 71 | 2,010
Multiple myeloma 68 | 1,332
subependymal giant cell astrocytoma 67 | 2,287
Kidney cancer 66 | 2,613
group 4 medulloblastoma 61 | 1,855
Schizophrenia 59 | 1,160
interstitial cystitis 58 | 2,312
ulcerative colitis 57 | 1,819
colon cancer 56 | 1,478
cystic fibrosis 55 | 1,696
pituitary cancer 53 | 1,972
Autosomal recessive predisposition 51 | 1,442
adrenocortical carcinoma 50 | 1,428
astrocytoma 48 | 1,146
pancreatic ductal adenocarcinoma liver metastasis 48 | 1,962
Rheumatoid arthritis 47 | 1,191
cutaneous lupus erythematosus 45 | 1,057
Bipolar Disorder 44 | 666
acute quadriplegic myopathy 44 | 1,158
pediatric high grade glioma 44 | 1,064
Pick disease 43 | 1,894
Intellectual disability 41 | 1,016
dermatomyositis 38 | 966
primary pancreatic ductal adenocarcinoma 38 | 1,109
Waldenstrons macroglobulinemia 37 | 765
nasopharyngeal carcinoma 37 | 1,058
Breast Neoplasms 36 | 445
Liver Cirrhosis, Experimental 36 | 769
Hypertension 35 | 396
Obesity 35 | 678
Mammary Neoplasms 34 | 425
Prostatic Neoplasms 34 | 495
Down syndrome 32 | 499
pancreatic carcinoma 32 | 562
Epilepsy 31 | 792
Seizures 31 | 596
Hypertensive disease 30 | 292
gastric carcinoma 30 | 807
spina bifida 30 | 1,074
fibroadenoma 28 | 559
Asthma 27 | 385
Parkinson's disease 27 | 392
aldosterone-producing adenoma 27 | 665
esophageal adenocarcinoma 27 | 737
gastric cancer 27 | 459
juvenile dermatomyositis 27 | 1,187
Endometriosis 26 | 540
Kidney disease 26 | 430
Melanoma 26 | 711
Vascular disease 26 | 319
acute myeloid leukemia 26 | 783
hepatocellular carcinoma 26 | 547
non-small cell lung carcinoma 26 | 317
Depressive disorder 25 | 409
Short stature 25 | 531
Atopic dermatitis 24 | 952
Cleft Palate 24 | 271
Lung Neoplasms 24 | 232
Muscle hypotonia 24 | 571
medulloblastoma 24 | 720
Alzheimer's disease 23 | 658
Attention deficit hyperactivity disorder 23 | 278
Cognitive delay 23 | 608
Coronary artery disease 23 | 268
Global developmental delay 23 | 608
Mental and motor retardation 23 | 608
Stomach Neoplasms 23 | 300
Strabismus 23 | 270
non primary Sjogren syndrome sicca 23 | 891
Low intelligence 22 | 645
Mental Retardation 22 | 645

Tissue

Endocrine System 456 | 18,159
Skin and soft tissues 450 | 17,230
Female tissues 449 | 17,400
Digestive Tract 447 | 17,369
Liver and Pancreas 438 | 16,750
Male tissues 437 | 17,142
Nervous System 435 | 16,725
Urinary Tract 432 | 16,678
Blood and immune system 428 | 16,909
Respiratory system 416 | 16,393
Cardiovascular System 401 | 15,192

Target Family

Non-IDG 237 | 12,091
Transcription Factor 106 | 1,400
Enzyme 60 | 4,145
Kinase 21 | 634
GPCR 18 | 408
Ion Channel 12 | 344
Nuclear Receptor 7 | 48
Transporter 7 | 473
Epigenetic 5 | 242

GO Function

protein heterodimerization act... 473 | 473
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sorcin SRI Tbio Non-IDG -2.69915 481.5 119
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
Tropomyosin alpha-4 chain TPM4 Tbio Non-IDG -1.57899 37.4 120
Organic solute transporter subunit beta SLC51B Tbio Transporter -1.41741 22.6 42
Histone H2A.J H2AFJ Tdark Non-IDG -0.00172 0.83 99
Zinc finger protein Helios IKZF2 Tbio Transcription Factor -1.26324 15.8 221
Sorting nexin-5 SNX5 Tbio Non-IDG -1.23706 20.8 141
Doublesex- and mab-3-related transcription factor 1 DMRT1 Tbio Transcription Factor -2.31269 210.5 197
Histone H2A type 1-A HIST1H2AA Tbio Non-IDG -0.84480 8.19 69
Pannexin-1 PANX1 Tbio Ion Channel -2.59888 418.5 154