Development Level

Tbio 317 | 11,178
Tchem 86 | 1,885
Tclin 42 | 612
Tdark 28 | 6,569

Collection

Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 27 | 979
preweaning lethality, incomple... 14 | 499
embryonic lethality prior to t... 10 | 278
abnormal behavior 8 | 298
embryonic lethality prior to o... 8 | 239
decreased total body fat amoun... 7 | 207
abnormal embryo size 6 | 220
decreased vertical activity 6 | 208
hyperactivity 6 | 148
increased lean body mass 6 | 172
increased mean corpuscular vol... 6 | 92
increased startle reflex 6 | 112
abnormal retina morphology 5 | 71
decreased fasted circulating g... 5 | 65
abnormal lens morphology 4 | 81
abnormal tooth morphology 4 | 24
decreased body weight 4 | 161
decreased bone mineral density 4 | 126
decreased lean body mass 4 | 135
decreased leukocyte cell numbe... 4 | 73
decreased lymphocyte cell numb... 4 | 83
increased bone mineral content 4 | 108
increased bone mineral density 4 | 72
increased total body fat amoun... 4 | 134
male infertility 4 | 123
prenatal lethality prior to he... 4 | 87
abnormal kidney morphology 3 | 65
cataract 3 | 92
decreased bone mineral content 3 | 151
decreased circulating amylase ... 3 | 28
decreased circulating choleste... 3 | 93
decreased circulating insulin ... 3 | 76
decreased circulating triglyce... 3 | 79
decreased hemoglobin content 3 | 68
embryonic growth retardation 3 | 106
enlarged spleen 3 | 41
increased grip strength 3 | 41
increased mean corpuscular hem... 3 | 96
long tibia 3 | 25
vertebral fusion 3 | 23
abnormal behavioral response t... 2 | 66
abnormal bone mineralization 2 | 38
abnormal bone structure 2 | 187
abnormal cranium morphology 2 | 36
abnormal embryo turning 2 | 31
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal seminal vesicle morph... 2 | 114
abnormal spleen morphology 2 | 55
abnormal vertebrae morphology 2 | 18
decreased IgG1 level 2 | 8
decreased blood urea nitrogen ... 2 | 51
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating alanine ... 2 | 47
decreased circulating chloride... 2 | 30
decreased circulating glucose ... 2 | 126
decreased circulating potassiu... 2 | 20
decreased erythrocyte cell num... 2 | 62
decreased hematocrit 2 | 46
decreased mean corpuscular hem... 2 | 31
decreased prepulse inhibition 2 | 82
enlarged heart 2 | 210
enlarged testis 2 | 6
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased circulating potassiu... 2 | 29
increased circulating triglyce... 2 | 42
increased erythrocyte cell num... 2 | 39
increased neutrophil cell numb... 2 | 46
increased red blood cell distr... 2 | 34
microphthalmia 2 | 26
persistence of hyaloid vascula... 2 | 33
polycystic kidney 2 | 15
small superior vagus ganglion 2 | 74
abnormal craniofacial morpholo... 1 | 33
abnormal ear morphology 1 | 9
abnormal neural tube closure 1 | 46
convulsive seizures 1 | 13
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased circulating creatine... 1 | 4
decreased circulating magnesiu... 1 | 13
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating creatine... 1 | 5
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
prenatal lethality 1 | 28
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Carcinoma 277 | 11,192
ovarian cancer 230 | 8,297
psoriasis 196 | 6,514
osteosarcoma 194 | 7,766
glioblastoma 171 | 5,635
lung cancer 166 | 4,607
medulloblastoma, large-cell 154 | 6,086
atypical teratoid / rhabdoid tumor 141 | 4,971
Cancer 130 | 2,388
ependymoma 129 | 4,559
Breast cancer 116 | 3,469
group 3 medulloblastoma 113 | 4,002
invasive ductal carcinoma 107 | 2,867
adult high grade glioma 104 | 3,701
malignant mesothelioma 104 | 3,135
lung adenocarcinoma 94 | 2,627
Astrocytoma, Pilocytic 92 | 3,006
intraductal papillary-mucinous carcinoma (IPMC) 90 | 2,902
oligodendroglioma 89 | 2,768
lung carcinoma 88 | 2,755
pancreatic cancer 88 | 2,322
intraductal papillary-mucinous neoplasm (IPMN) 86 | 3,204
non-small cell lung cancer 85 | 2,799
primitive neuroectodermal tumor 81 | 2,957
diabetes mellitus 77 | 1,683
astrocytic glioma 75 | 2,530
ductal carcinoma in situ 74 | 1,686
breast carcinoma 72 | 1,589
intraductal papillary-mucinous adenoma (IPMA) 71 | 2,872
tuberculosis 67 | 1,963
Multiple myeloma 65 | 1,296
subependymal giant cell astrocytoma 64 | 2,230
Kidney cancer 62 | 2,548
group 4 medulloblastoma 55 | 1,806
ulcerative colitis 55 | 1,765
Schizophrenia 54 | 1,136
interstitial cystitis 52 | 2,237
colon cancer 51 | 1,428
cystic fibrosis 51 | 1,629
Autosomal recessive predisposition 49 | 1,407
pituitary cancer 49 | 1,915
pancreatic ductal adenocarcinoma liver metastasis 47 | 1,911
adrenocortical carcinoma 45 | 1,385
astrocytoma 44 | 1,113
cutaneous lupus erythematosus 44 | 1,016
Rheumatoid arthritis 43 | 1,156
Pick disease 42 | 1,856
pediatric high grade glioma 42 | 1,035
acute quadriplegic myopathy 41 | 1,133
Bipolar Disorder 38 | 646
Intellectual disability 36 | 998
dermatomyositis 36 | 941
primary pancreatic ductal adenocarcinoma 36 | 1,071
Waldenstrons macroglobulinemia 35 | 742
Hypertension 34 | 372
Obesity 33 | 655
Prostatic Neoplasms 33 | 472
Breast Neoplasms 32 | 423
nasopharyngeal carcinoma 32 | 1,024
pancreatic carcinoma 32 | 555
Liver Cirrhosis, Experimental 31 | 733
Down syndrome 30 | 480
Mammary Neoplasms 30 | 403
spina bifida 30 | 1,053
Hypertensive disease 29 | 278
Asthma 27 | 370
Epilepsy 27 | 775
Seizures 27 | 584
gastric carcinoma 27 | 781
fibroadenoma 26 | 538
Kidney disease 25 | 411
Melanoma 25 | 689
juvenile dermatomyositis 25 | 1,147
Short stature 24 | 514
non-small cell lung carcinoma 24 | 302
Cleft Palate 23 | 265
Endometriosis 23 | 521
Muscle hypotonia 23 | 562
Parkinson's disease 23 | 378
Vascular disease 23 | 294
acute myeloid leukemia 23 | 760
aldosterone-producing adenoma 23 | 646
esophageal adenocarcinoma 23 | 696
gastric cancer 23 | 445
hepatocellular carcinoma 23 | 536
Atopic dermatitis 22 | 915
Coronary artery disease 22 | 253
Stomach Neoplasms 22 | 287
Strabismus 22 | 265
medulloblastoma 22 | 702
Alzheimer's disease 21 | 640
Attention deficit hyperactivity disorder 21 | 272
Cognitive delay 21 | 596
Global developmental delay 21 | 596
Lung Neoplasms 21 | 217
Mental and motor retardation 21 | 596
Mandibular hypoplasia 20 | 273
Mental Retardation 20 | 634
Micrognathism 20 | 273
Orbital separation excessive 20 | 240

Tissue

Endocrine System 456 | 18,159
Skin and soft tissues 450 | 17,230
Female tissues 449 | 17,400
Digestive Tract 447 | 17,369
Liver and Pancreas 438 | 16,750
Male tissues 437 | 17,142
Nervous System 435 | 16,725
Urinary Tract 432 | 16,678
Blood and immune system 428 | 16,909
Respiratory system 416 | 16,393
Cardiovascular System 401 | 15,192

Target Family

Non-IDG 237 | 12,091
Transcription Factor 106 | 1,400
Enzyme 60 | 4,145
Kinase 21 | 634
GPCR 18 | 408
Ion Channel 12 | 344
Nuclear Receptor 7 | 48
Transporter 7 | 473
Epigenetic 5 | 242

GO Function

protein heterodimerization act... 473 | 473
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Taste receptor type 1 member 2 TAS1R2 Tchem GPCR -2.03403 100.4 150
Histone H2A-Bbd type 2/3 H2AFB3 Tdark Non-IDG -0.25594 2.36 13
Protein SOX-15 SOX15 Tbio Transcription Factor -1.31464 23.3 166
Bcl-2 homologous antagonist/killer BAK1 Tchem Non-IDG -2.29199 175.9 554
Transcription initiation factor TFIID subunit 1 TAF1 Tbio Kinase -2.64215 426.1 228
Teneurin-3 TENM3 Tbio Non-IDG -2.01347 99.4 64
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like BNIP3L Tbio Non-IDG -2.20837 153.7 355