Development Level

Tbio 185 | 11,651
Tchem 34 | 1,388
Tclin 15 | 612
Tdark 7 | 6,593

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 16 | 979
decreased total body fat amoun... 8 | 207
increased lean body mass 7 | 172
preweaning lethality, incomple... 7 | 499
increased circulating alkaline... 6 | 122
abnormal behavior 5 | 298
decreased circulating serum al... 5 | 82
abnormal bone structure 4 | 187
abnormal retina morphology 4 | 71
abnormal skin morphology 4 | 50
embryonic lethality prior to o... 4 | 239
increased bone mineral content 4 | 108
increased bone mineral density 4 | 72
increased circulating HDL chol... 4 | 80
increased heart weight 4 | 62
increased mean corpuscular hem... 4 | 96
abnormal embryo size 3 | 220
abnormal heart morphology 3 | 162
cataract 3 | 92
decreased body weight 3 | 161
decreased circulating total pr... 3 | 49
decreased grip strength 3 | 116
decreased lean body mass 3 | 135
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular hem... 3 | 50
decreased mean corpuscular vol... 3 | 79
decreased vertical activity 3 | 208
embryonic lethality prior to t... 3 | 278
enlarged heart 3 | 210
hyperactivity 3 | 148
increased circulating choleste... 3 | 66
increased fasted circulating g... 3 | 76
increased mean corpuscular vol... 3 | 92
increased startle reflex 3 | 112
increased total body fat amoun... 3 | 134
short tibia 3 | 97
abnormal behavioral response t... 2 | 66
abnormal bone mineralization 2 | 38
abnormal eye morphology 2 | 68
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
abnormal sleep behavior 2 | 70
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating aspartat... 2 | 34
decreased circulating creatini... 2 | 39
decreased circulating insulin ... 2 | 76
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
embryonic growth retardation 2 | 106
hypoactivity 2 | 132
increased circulating LDL chol... 2 | 13
increased circulating total pr... 2 | 28
increased circulating triglyce... 2 | 42
increased lymphocyte cell numb... 2 | 32
increased neutrophil cell numb... 2 | 46
abnormal body wall morphology 1 | 9
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
absent spleen 1 | 3
decreased IgE level 1 | 6
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating iron lev... 1 | 32
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
enlarged spleen 1 | 41
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
limb grasping 1 | 41
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
small testis 1 | 58
stereotypic behavior 1 | 3
trunk curl 1 | 16
vertebral fusion 1 | 23

Disease

Carcinoma 162 | 11,493
ovarian cancer 143 | 8,519
osteosarcoma 139 | 7,950
glioblastoma 121 | 5,792
medulloblastoma, large-cell 118 | 6,241
psoriasis 100 | 6,694
atypical teratoid / rhabdoid tumor 97 | 5,112
lung cancer 92 | 4,740
Cancer 90 | 2,499
adult high grade glioma 83 | 3,801
ependymoma 78 | 4,679
group 3 medulloblastoma 76 | 4,104
Astrocytoma, Pilocytic 64 | 3,081
Breast cancer 60 | 3,577
primitive neuroectodermal tumor 58 | 3,035
oligodendroglioma 57 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 55 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 55 | 3,290
malignant mesothelioma 54 | 3,232
astrocytic glioma 53 | 2,597
pancreatic cancer 50 | 2,398
lung adenocarcinoma 49 | 2,716
subependymal giant cell astrocytoma 48 | 2,287
Pick disease 47 | 1,894
invasive ductal carcinoma 47 | 2,950
diabetes mellitus 43 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 43 | 2,954
non-small cell lung cancer 43 | 2,890
Kidney cancer 42 | 2,613
Multiple myeloma 39 | 1,332
acute quadriplegic myopathy 37 | 1,158
pancreatic ductal adenocarcinoma liver metastasis 36 | 1,962
Schizophrenia 35 | 1,160
colon cancer 35 | 1,478
lung carcinoma 35 | 2,843
ductal carcinoma in situ 34 | 1,744
astrocytoma 33 | 1,146
interstitial cystitis 33 | 2,312
tuberculosis 33 | 2,010
breast carcinoma 32 | 1,637
dermatomyositis 32 | 966
juvenile dermatomyositis 32 | 1,187
pituitary cancer 31 | 1,972
Autosomal recessive predisposition 30 | 1,442
primary pancreatic ductal adenocarcinoma 29 | 1,108
Waldenstrons macroglobulinemia 27 | 765
group 4 medulloblastoma 27 | 1,855
Intellectual disability 26 | 1,016
Bipolar Disorder 25 | 666
Epilepsy 25 | 792
Rheumatoid arthritis 25 | 1,191
ulcerative colitis 25 | 1,819
cystic fibrosis 24 | 1,695
progressive supranuclear palsy 20 | 676
Cognitive delay 19 | 608
Duchenne muscular dystrophy 19 | 601
Global developmental delay 19 | 608
Mental and motor retardation 19 | 608
active Crohn's disease 18 | 922
active ulcerative colitis 18 | 764
adrenocortical carcinoma 18 | 1,428
nasopharyngeal carcinoma 18 | 1,058
Obesity 17 | 678
Parkinson's disease 17 | 392
Seizures 17 | 596
Short stature 17 | 531
acute myeloid leukemia 17 | 783
aldosterone-producing adenoma 17 | 665
pediatric high grade glioma 17 | 1,064
Breast Neoplasms 16 | 445
Liver Cirrhosis, Experimental 16 | 769
cutaneous lupus erythematosus 16 | 1,057
non primary Sjogren syndrome sicca 16 | 891
spina bifida 16 | 1,074
Amyotrophic lateral sclerosis 15 | 451
Autistic Disorder 15 | 364
Depressive disorder 15 | 409
Prostatic Neoplasms 15 | 495
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 510
medulloblastoma 15 | 720
Dull intelligence 14 | 645
Low intelligence 14 | 645
Mammary Neoplasms 14 | 425
Mental Retardation 14 | 645
Mental deficiency 14 | 645
Muscle hypotonia 14 | 571
Poor school performance 14 | 645
esophageal adenocarcinoma 14 | 737
Alzheimer's disease 13 | 658
Orbital separation excessive 13 | 244
Small head 13 | 374
atypical teratoid/rhabdoid tumor 13 | 357
Acquired scoliosis 12 | 281
Curvature of spine 12 | 282
Down syndrome 12 | 499
Endometriosis 12 | 540
Strabismus 12 | 270
gastric cancer 12 | 459
gastric carcinoma 12 | 807
pancreatic carcinoma 12 | 562

Tissue

Endocrine System 239 | 18,159
Digestive Tract 238 | 17,369
Female tissues 236 | 17,400
Skin and soft tissues 236 | 17,230
Liver and Pancreas 234 | 16,750
Male tissues 234 | 17,142
Nervous System 233 | 16,725
Blood and immune system 232 | 16,909
Urinary Tract 232 | 16,678
Respiratory system 230 | 16,393
Cardiovascular System 218 | 15,192

Target Family

Non-IDG 145 | 12,091
Enzyme 37 | 4,145
Transcription Factor 29 | 1,400
Kinase 12 | 634
Nuclear Receptor 6 | 48
Ion Channel 5 | 344
Epigenetic 2 | 242
GPCR 2 | 408
Transporter 2 | 473
TF/Epigenetic 1 | 38

GO Function

protein domain specific bindin... 241 | 241
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Chromobox protein homolog 3 CBX3 Tbio Epigenetic -2.00023 90.5 366
Nuclear factor erythroid 2-related factor 1 NFE2L1 Tbio Transcription Factor -1.57346 40.9 157
Protein crumbs homolog 3 CRB3 Tbio Non-IDG -1.22596 16.1 79
Drebrin-like protein DBNL Tbio Non-IDG -1.16567 21.1 172
Integrin alpha-3 ITGA3 Tbio Non-IDG -2.08360 104.1 587
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Ezrin EZR Tbio Non-IDG -2.99865 981.3 1088
Cbp/p300-interacting transactivator 2 CITED2 Tbio Non-IDG -2.07760 134.8 167
Interactor protein for cytohesin exchange factors 1 IPCEF1 Tbio Non-IDG -0.36270 2.87 93
Importin subunit beta-1 KPNB1 Tbio Non-IDG -1.63038 38.8 174