Development Level

Tbio 78 | 10,625
Tchem 16 | 1,890
Tclin 6 | 602
Tdark 2 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

decreased total body fat amoun... 5 | 186
decreased circulating serum al... 4 | 79
preweaning lethality, complete... 4 | 633
abnormal behavior 3 | 226
abnormal retina morphology 2 | 100
abnormal skin morphology 2 | 23
decreased body length 2 | 108
decreased body weight 2 | 174
decreased fasted circulating g... 2 | 49
decreased lean body mass 2 | 195
embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
increased bone mineral density 2 | 52
increased circulating HDL chol... 2 | 63
increased circulating alkaline... 2 | 119
increased circulating choleste... 2 | 53
increased fasted circulating g... 2 | 68
increased lean body mass 2 | 107
short tibia 2 | 82
abnormal body wall morphology 1 | 7
abnormal coat appearance 1 | 25
abnormal coat/hair pigmentatio... 1 | 54
abnormal coping response 1 | 12
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal external female genit... 1 | 1
abnormal external male genital... 1 | 1
abnormal femur morphology 1 | 14
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 51
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 14
abnormal optic disc morphology 1 | 10
abnormal response to tactile s... 1 | 16
abnormal tail morphology 1 | 17
abnormal tail movements 1 | 12
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 14
abnormal vibrissa morphology 1 | 17
decreased IgE level 1 | 3
decreased IgG1 level 1 | 4
decreased NK T cell number 1 | 28
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased grip strength 1 | 123
decreased hemoglobin content 1 | 53
decreased mean corpuscular vol... 1 | 50
enlarged spleen 1 | 26
hyperactivity 1 | 108
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
improved glucose tolerance 1 | 56
increased bone mineral content 1 | 92
increased circulating free fat... 1 | 17
increased circulating total pr... 1 | 20
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased mature B cell number 1 | 12
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
preweaning lethality, incomple... 1 | 260
protruding tongue 1 | 1
straub tail 1 | 26
vertebral fusion 1 | 23

Disease

ovarian cancer 65 | 8,484
osteosarcoma 64 | 7,933
psoriasis 48 | 6,685
glioblastoma 47 | 5,572
medulloblastoma, large-cell 46 | 6,234
Cancer 37 | 2,346
atypical teratoid / rhabdoid tumor 36 | 4,369
lung cancer 36 | 4,466
pilocytic astrocytoma 28 | 3,086
pancreatic cancer 25 | 2,300
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,289
malignant mesothelioma 22 | 3,162
pediatric high grade glioma 22 | 2,712
subependymal giant cell astrocytoma 22 | 2,287
Breast cancer 21 | 3,094
adult high grade glioma 20 | 2,148
astrocytoma 20 | 1,493
oligodendroglioma 20 | 2,849
invasive ductal carcinoma 19 | 2,950
lung adenocarcinoma 19 | 2,713
primitive neuroectodermal tumor 19 | 3,031
Pick disease 18 | 1,893
diabetes mellitus 18 | 1,663
medulloblastoma 18 | 1,524
primary pancreatic ductal adenocarcinoma 18 | 1,271
Rheumatoid Arthritis 17 | 1,160
astrocytic glioma 17 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
Carcinoma 15 | 2,147
Multiple myeloma 15 | 1,327
ependymoma 15 | 2,514
pituitary cancer 15 | 1,972
group 3 medulloblastoma 14 | 2,254
interstitial cystitis 14 | 2,299
tuberculosis 14 | 1,557
ulcerative colitis 14 | 2,087
acute quadriplegic myopathy 13 | 1,157
cystic fibrosis 13 | 1,665
dermatomyositis 13 | 933
ductal carcinoma in situ 13 | 1,745
juvenile dermatomyositis 13 | 1,189
Waldenstrons macroglobulinemia 12 | 765
lung carcinoma 12 | 2,844
acute myeloid leukemia 11 | 780
colon cancer 11 | 1,475
posterior fossa group A ependymoma 11 | 1,511
breast carcinoma 10 | 1,614
gastric carcinoma 10 | 832
non primary Sjogren syndrome sicca 10 | 840
non-small cell lung cancer 10 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
Amyotrophic Lateral Sclerosis 9 | 431
group 4 medulloblastoma 9 | 1,875
progressive supranuclear palsy 9 | 674
Alzheimer's disease 8 | 644
Duchenne muscular dystrophy 8 | 602
nasopharyngeal carcinoma 8 | 1,056
Endometriosis 7 | 535
Kidney disease 7 | 396
posterior fossa group B ependymoma 7 | 1,530
sonic hedgehog group medulloblastoma 7 | 1,482
spina bifida 7 | 1,064
Cerebrovascular disease 6 | 231
Epilepsy 6 | 346
Heart disease 6 | 279
adrenocortical carcinoma 6 | 1,427
aldosterone-producing adenoma 6 | 664
atypical teratoid/rhabdoid tumor 6 | 1,095
esophageal adenocarcinoma 6 | 737
gastric cancer 6 | 430
hepatocellular carcinoma 6 | 532
inflammatory breast cancer 6 | 404
pancreatic carcinoma 6 | 567
tuberculosis and treatment for 6 months 6 | 686
Cardiomyopathies 5 | 90
Hypertension 5 | 287
Liver carcinoma 5 | 217
Mammary Neoplasms 5 | 410
Obesity 5 | 616
Prostatic Neoplasms 5 | 471
Schizophrenia 5 | 501
active Crohn's disease 5 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
Autistic Disorder 4 | 320
Cholestasis 4 | 93
Coronary artery disease 4 | 240
IGA Glomerulonephritis 4 | 454
Intellectual disability 4 | 573
Microcephaly 4 | 149
Myocardial Ischemia 4 | 169
Neurodegenerative disease 4 | 383
Osteoporosis 4 | 257
Parkinson's disease 4 | 364
Polycystic Ovary Syndrome 4 | 332
Toxic encephalopathy 4 | 131
fibroadenoma 4 | 557
hereditary spastic paraplegia 4 | 313
non-small cell lung carcinoma 4 | 413
urothelial carcinoma 4 | 318

Tissue

Blood and immune system 102 | 17,995
Digestive Tract 102 | 18,473
Endocrine System 102 | 18,512
Female tissues 102 | 18,647
Liver and Pancreas 102 | 18,136
Male tissues 102 | 17,969
Nervous System 102 | 18,561
Respiratory system 102 | 17,484
Urinary Tract 102 | 18,444
Cardiovascular System 101 | 17,958
Skin and soft tissues 101 | 18,115

Target Family

Non-IDG 64 | 11,971
Enzyme 15 | 4,146
Transcription Factor 11 | 1,400
Nuclear Receptor 5 | 48
Kinase 3 | 634
Ion Channel 2 | 341
Epigenetic 1 | 242
TF/Epigenetic 1 | 38

GO Function

protein domain specific bindin... 102 | 102
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
Methyl-CpG-binding protein 2 MECP2 Tchem Transcription Factor -3.22710 1827.6 567
Oxysterol-binding protein 1 OSBP Tbio Non-IDG -2.19920 167.0 156
78 kDa glucose-regulated protein HSPA5 Tchem Non-IDG -3.28487 2003.3 918
DNA repair protein complementing XP-A cells XPA Tbio Non-IDG -2.82887 674.6 301
Histone H4 HIST2H4A Tbio Non-IDG -2.57230 138.5 770
Nuclear receptor subfamily 0 group B member 1 NR0B1 Tchem Nuclear Receptor -2.70036 522.8 435
Plexin-B3 PLXNB3 Tbio Non-IDG -0.88703 9.74 43
Stathmin-3 STMN3 Tbio Non-IDG -1.11235 13.0 133