Development Level

Tbio 125 | 11,445
Tdark 18 | 6,588
Tchem 15 | 1,598
Tclin 3 | 613

Collection

RFA-RM-18-021 2 | 328
GPCR: IDG Consortium (Complete... 1 | 25
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, incomple... 6 | 499
increased total body fat amoun... 4 | 134
decreased vertical activity 3 | 208
increased lean body mass 3 | 172
preweaning lethality, complete... 3 | 979
abnormal bone structure 2 | 187
abnormal heart morphology 2 | 162
abnormal testis morphology 2 | 43
decreased body weight 2 | 161
decreased circulating HDL chol... 2 | 68
decreased circulating bilirubi... 2 | 19
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased circulating serum al... 2 | 82
decreased lean body mass 2 | 135
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased bone mineral density 2 | 72
increased circulating choleste... 2 | 66
increased circulating creatini... 2 | 38
increased mean corpuscular hem... 2 | 96
increased mean corpuscular hem... 2 | 36
male infertility 2 | 123
abnormal behavior 1 | 298
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal facial morphology 1 | 17
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal head size 1 | 6
abnormal kidney morphology 1 | 65
abnormal outer ear morphology 1 | 3
abnormal ovary morphology 1 | 7
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal tail morphology 1 | 25
abnormal tooth morphology 1 | 24
absent epididymis 1 | 3
absent ovary 1 | 3
absent seminal vesicle 1 | 4
absent testes 1 | 6
anophthalmia 1 | 33
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating fructosa... 1 | 30
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased prepulse inhibition 1 | 82
enlarged kidney 1 | 14
enlarged spleen 1 | 41
female infertility 1 | 60
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating free fat... 1 | 20
increased circulating fructosa... 1 | 13
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
mammalian phenotype 1 | 17
premature death 1 | 5
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
small superior vagus ganglion 1 | 74
small testis 1 | 58
small uterus 1 | 3

Disease

Carcinoma 95 | 11,493
ovarian cancer 80 | 8,520
osteosarcoma 65 | 7,950
medulloblastoma, large-cell 63 | 6,241
psoriasis 59 | 6,694
glioblastoma 51 | 5,792
atypical teratoid / rhabdoid tumor 49 | 5,112
ependymoma 45 | 4,679
Cancer 43 | 2,499
group 3 medulloblastoma 41 | 4,104
lung cancer 41 | 4,740
Breast cancer 40 | 3,578
malignant mesothelioma 38 | 3,232
invasive ductal carcinoma 37 | 2,951
interstitial cystitis 33 | 2,312
oligodendroglioma 33 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 31 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 31 | 3,291
adult high grade glioma 29 | 3,801
astrocytic glioma 27 | 2,597
pituitary cancer 26 | 1,972
lung adenocarcinoma 25 | 2,716
Kidney cancer 24 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
Astrocytoma, Pilocytic 23 | 3,081
non-small cell lung cancer 23 | 2,890
primitive neuroectodermal tumor 23 | 3,035
ductal carcinoma in situ 22 | 1,745
pancreatic cancer 22 | 2,398
lung carcinoma 21 | 2,843
subependymal giant cell astrocytoma 20 | 2,287
Schizophrenia 19 | 1,160
cystic fibrosis 19 | 1,696
cutaneous lupus erythematosus 18 | 1,057
diabetes mellitus 17 | 1,728
Pick disease 16 | 1,894
breast carcinoma 16 | 1,638
ulcerative colitis 16 | 1,819
Prostatic Neoplasms 15 | 495
group 4 medulloblastoma 15 | 1,855
active Crohn's disease 14 | 922
colon cancer 14 | 1,478
Obesity 13 | 678
Rheumatoid arthritis 13 | 1,191
adrenocortical carcinoma 13 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
tuberculosis 13 | 2,010
Atopic dermatitis 12 | 952
Breast Neoplasms 12 | 445
Mammary Neoplasms 12 | 425
Neurodegenerative disease 12 | 414
acute quadriplegic myopathy 12 | 1,158
astrocytoma 12 | 1,146
pediatric high grade glioma 12 | 1,064
posterior fossa group A ependymoma 12 | 468
primary pancreatic ductal adenocarcinoma 12 | 1,109
Autosomal recessive predisposition 11 | 1,442
Liver Cirrhosis, Experimental 11 | 769
medulloblastoma 11 | 720
non primary Sjogren syndrome sicca 11 | 891
Bipolar Disorder 10 | 666
Multiple myeloma 10 | 1,332
Stomach Neoplasms 10 | 300
fibroadenoma 10 | 559
Epilepsy 9 | 792
Multiple Sclerosis 9 | 540
Seizures 9 | 596
aldosterone-producing adenoma 9 | 665
nasopharyngeal carcinoma 9 | 1,058
spina bifida 9 | 1,074
Dull intelligence 8 | 645
Intellectual disability 8 | 1,016
Low intelligence 8 | 645
Mammary Neoplasms, Experimental 8 | 154
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
juvenile dermatomyositis 8 | 1,187
Animal Mammary Neoplasms 7 | 136
Broad flat nasal bridge 7 | 236
Cleft Palate 7 | 271
Depressive disorder 7 | 409
Mammary Neoplasms, Animal 7 | 136
Nasal bridge wide 7 | 236
Renal Cell Carcinoma 7 | 214
active ulcerative colitis 7 | 764
dermatomyositis 7 | 966
esophageal adenocarcinoma 7 | 737
Chronic Lymphocytic Leukemia 6 | 262
Crohn's disease 6 | 321
Down syndrome 6 | 499
Endometriosis 6 | 540
Immune system cancer 6 | 140
Polycystic ovary syndrome 6 | 360
Prostate cancer 6 | 175
Small head 6 | 374
Strabismus 6 | 270
Waldenstrons macroglobulinemia 6 | 765
acute myeloid leukemia 6 | 783
sonic hedgehog group medulloblastoma 6 | 467

Tissue

Endocrine System 153 | 18,159
Digestive Tract 147 | 17,369
Female tissues 147 | 17,400
Skin and soft tissues 146 | 17,230
Nervous System 144 | 16,725
Male tissues 142 | 17,142
Urinary Tract 139 | 16,678
Blood and immune system 138 | 16,909
Respiratory system 137 | 16,393
Liver and Pancreas 133 | 16,750
Cardiovascular System 124 | 15,192

Target Family

Transcription Factor 87 | 1,400
Non-IDG 45 | 12,091
Enzyme 15 | 4,145
Kinase 4 | 634
GPCR 3 | 408
Transporter 3 | 473
Epigenetic 1 | 242
Ion Channel 1 | 344
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

GO Function

protein dimerization activity 161 | 161
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 SOHLH2 Tbio Transcription Factor -1.26578 21.4 126
Hairy/enhancer-of-split related with YRPW motif protein 1 HEY1 Tbio Transcription Factor -2.28398 163.4 335
Achaete-scute homolog 2 ASCL2 Tbio Transcription Factor -1.84293 66.0 190
Transcription factor-like 5 protein TCFL5 Tbio Transcription Factor -2.62447 404.7 161
Transcription factor HES-2 HES2 Tdark Transcription Factor -0.19957 1.87 213
Aryl hydrocarbon receptor repressor AHRR Tbio Transcription Factor -1.68768 52.8 77
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform PPP3CB Tbio Enzyme -1.53531 28.2 147
Neurogenic differentiation factor 6 NEUROD6 Tbio Transcription Factor -1.51923 32.8 133
Neurogenic differentiation factor 4 NEUROD4 Tbio Transcription Factor -1.14336 11.7 62
Achaete-scute homolog 4 ASCL4 Tdark Transcription Factor -0.31083 1.97 22