Development Level

Tbio 38 | 11,445
Tchem 1 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

decreased total body fat amoun... 2 | 207
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating phosphat... 1 | 26
thrombocytopenia 1 | 56

Disease

osteosarcoma 28 | 7,950
Carcinoma 26 | 11,493
ovarian cancer 25 | 8,520
medulloblastoma, large-cell 21 | 6,241
psoriasis 19 | 6,694
glioblastoma 18 | 5,792
atypical teratoid / rhabdoid tumor 16 | 5,112
lung cancer 16 | 4,740
Kidney cancer 15 | 2,613
Breast cancer 13 | 3,578
ependymoma 13 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
non-small cell lung cancer 13 | 2,890
adult high grade glioma 12 | 3,801
group 3 medulloblastoma 12 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
malignant mesothelioma 11 | 3,232
primitive neuroectodermal tumor 11 | 3,035
Astrocytoma, Pilocytic 10 | 3,081
lung adenocarcinoma 10 | 2,716
Cancer 9 | 2,499
Pick disease 9 | 1,894
invasive ductal carcinoma 9 | 2,951
lung carcinoma 9 | 2,843
pituitary cancer 9 | 1,972
astrocytic glioma 8 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
oligodendroglioma 8 | 2,850
Schizophrenia 7 | 1,160
breast carcinoma 7 | 1,638
ductal carcinoma in situ 7 | 1,745
pancreatic cancer 7 | 2,398
spina bifida 7 | 1,074
subependymal giant cell astrocytoma 7 | 2,287
Autosomal recessive predisposition 6 | 1,442
astrocytoma 6 | 1,146
colon cancer 6 | 1,478
cystic fibrosis 6 | 1,696
group 4 medulloblastoma 6 | 1,855
Amyotrophic lateral sclerosis 5 | 451
Bipolar Disorder 5 | 666
Intellectual disability 5 | 1,016
Rheumatoid arthritis 5 | 1,191
ulcerative colitis 5 | 1,819
Alzheimer's disease 4 | 658
Down syndrome 4 | 499
Multiple myeloma 4 | 1,332
diabetes mellitus 4 | 1,728
interstitial cystitis 4 | 2,312
juvenile dermatomyositis 4 | 1,187
nasopharyngeal carcinoma 4 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pediatric high grade glioma 4 | 1,064
Creatine phosphokinase serum increased 3 | 110
Depressive disorder 3 | 409
Diabetes Mellitus, Experimental 3 | 108
Duchenne muscular dystrophy 3 | 601
Elevated creatine kinase 3 | 110
Endometrial cancer 3 | 311
Glaucoma 3 | 239
Heart disease 3 | 306
Hypertension 3 | 396
Liver cancer 3 | 604
Mental Depression 3 | 333
Myopathy 3 | 185
Osteoporosis 3 | 363
Parkinson's disease 3 | 392
Prostatic Neoplasms 3 | 495
acute quadriplegic myopathy 3 | 1,158
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
cutaneous lupus erythematosus 3 | 1,057
dermatomyositis 3 | 966
gastric carcinoma 3 | 807
non primary Sjogren syndrome sicca 3 | 891
pancreatic carcinoma 3 | 562
primary pancreatic ductal adenocarcinoma 3 | 1,109
urothelial carcinoma 3 | 318
Anorexia nervosa 2 | 80
Atrial Fibrillation 2 | 124
Gait Ataxia 2 | 51
Major Depressive Disorder 2 | 301
Melanoma 2 | 711
Mood Disorders 2 | 184
Neurodegenerative disease 2 | 414
Psychotic Disorders 2 | 151
Skin cancer 2 | 469
Substance-Related Disorders 2 | 115
Unipolar Depression 2 | 250
Vascular disease 2 | 319
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 922
adrenocortical carcinoma 2 | 1,428
aldosterone-producing adenoma 2 | 665
atypical teratoid/rhabdoid tumor 2 | 357
esophageal adenocarcinoma 2 | 737
hepatocellular carcinoma 2 | 547
medulloblastoma 2 | 720
mucosa-associated lymphoid tissue lymphoma 2 | 484
progressive supranuclear palsy 2 | 676
tuberculosis 2 | 2,010

Tissue

Blood and immune system 40 | 16,909
Cardiovascular System 40 | 15,192
Digestive Tract 40 | 17,369
Endocrine System 40 | 18,159
Female tissues 40 | 17,400
Liver and Pancreas 40 | 16,750
Male tissues 40 | 17,142
Respiratory system 40 | 16,393
Skin and soft tissues 40 | 17,230
Urinary Tract 40 | 16,678
Nervous System 39 | 16,725

Target Family

Non-IDG 30 | 12,091
Enzyme 7 | 4,145
Transporter 3 | 473

GO Function

protein complex scaffold activ... 40 | 40
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.08587 12.0 153
Protein WWC3 WWC3 Tbio Non-IDG -0.55831 4.90 66
MICOS complex subunit MIC19 CHCHD3 Tbio Non-IDG -1.16714 14.1 178
CCR4-NOT transcription complex subunit 1 CNOT1 Tbio Non-IDG -2.10799 119.0 37
Protein PAXX PAXX Tbio Non-IDG -1.45074 28.1 33
Plakophilin-2 PKP2 Tbio Non-IDG -2.10355 135.3 243
Eukaryotic translation initiation factor 3 subunit B EIF3B Tbio Non-IDG -1.83618 70.5 84
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 MAGI3 Tbio Enzyme -1.20980 18.0 42
Protein KIBRA WWC1 Tbio Non-IDG -1.96854 92.8 130
SAM and SH3 domain-containing protein 1 SASH1 Tbio Non-IDG -1.50284 36.9 182