Development Level

Tbio 74 | 10,625
Tchem 15 | 1,890
Tclin 5 | 602
Tdark 2 | 7,003

IMPC Term

preweaning lethality, complete... 12 | 633
embryonic lethality prior to t... 6 | 187
abnormal behavior 4 | 226
decreased grip strength 4 | 123
embryonic lethality prior to o... 4 | 148
hypoactivity 4 | 89
abnormal limb bud morphology 3 | 15
decreased body weight 3 | 174
decreased circulating HDL chol... 3 | 77
decreased lean body mass 3 | 195
increased circulating chloride... 3 | 43
abnormal allantois morphology 2 | 3
abnormal embryo size 2 | 112
abnormal neural tube closure 2 | 37
abnormal neural tube morpholog... 2 | 8
abnormal tail bud morphology 2 | 6
decreased caudal vertebrae num... 2 | 49
decreased circulating choleste... 2 | 85
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased total body fat amoun... 2 | 186
decreased total retina thickne... 2 | 20
impaired glucose tolerance 2 | 52
increased circulating phosphat... 2 | 24
increased grip strength 2 | 83
increased mean corpuscular hem... 2 | 25
increased mean corpuscular vol... 2 | 91
pallor 2 | 13
tremors 2 | 34
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal chorioallantoic fusio... 1 | 2
abnormal coat/ hair morphology 1 | 18
abnormal coat/hair pigmentatio... 1 | 54
abnormal cranium morphology 1 | 32
abnormal embryo turning 1 | 15
abnormal femur morphology 1 | 14
abnormal hair texture 1 | 4
abnormal heart morphology 1 | 51
abnormal lens morphology 1 | 73
abnormal limb position 1 | 3
abnormal locomotor activation 1 | 26
abnormal pericardium morpholog... 1 | 11
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal retinal vasculature m... 1 | 15
abnormal rib morphology 1 | 28
abnormal seminal vesicle morph... 1 | 47
abnormal sleep behavior 1 | 63
abnormal tail morphology 1 | 17
abnormal vertebrae morphology 1 | 14
abnormal vertebral arch morpho... 1 | 9
absent vibrissae 1 | 14
cardiovascular system phenotyp... 1 | 35
decreased KLRG1+ CD4 alpha bet... 1 | 2
decreased Ly6C low monocyte nu... 1 | 23
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased cervical vertebrae n... 1 | 12
decreased circulating LDL chol... 1 | 37
decreased circulating chloride... 1 | 32
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased effector memory CD8-... 1 | 24
decreased erythrocyte cell num... 1 | 43
decreased exploration in new e... 1 | 9
decreased fasted circulating g... 1 | 49
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased neutrophil cell numb... 1 | 37
decreased prepulse inhibition 1 | 52
edema 1 | 11
embryonic growth retardation 1 | 28
enlarged heart 1 | 111
enlarged spleen 1 | 26
hemorrhage 1 | 12
improved glucose tolerance 1 | 56
increased bone mineral content 1 | 92
increased circulating alkaline... 1 | 119
increased circulating aspartat... 1 | 17
increased circulating insulin ... 1 | 2
increased circulating sodium l... 1 | 71
increased effector memory CD4-... 1 | 15
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased or absent threshold ... 1 | 128
increased plasma cell number 1 | 5
increased red blood cell distr... 1 | 21
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 57
narrow eye opening 1 | 15
pale yolk sac 1 | 12
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82
thrombocytosis 1 | 23
vertebral fusion 1 | 23

Disease

ovarian cancer 57 | 8,484
osteosarcoma 54 | 7,933
glioblastoma 43 | 5,572
medulloblastoma, large-cell 42 | 6,234
atypical teratoid / rhabdoid tumor 32 | 4,369
psoriasis 31 | 6,685
lung cancer 25 | 4,466
Cancer 24 | 2,346
ependymoma 24 | 2,514
oligodendroglioma 24 | 2,849
pediatric high grade glioma 23 | 2,712
pilocytic astrocytoma 23 | 3,086
astrocytic glioma 22 | 2,241
Breast cancer 20 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,988
invasive ductal carcinoma 20 | 2,950
pancreatic cancer 20 | 2,300
primitive neuroectodermal tumor 20 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,289
subependymal giant cell astrocytoma 19 | 2,287
malignant mesothelioma 18 | 3,162
lung adenocarcinoma 17 | 2,713
lung carcinoma 17 | 2,844
Carcinoma 16 | 2,147
Pick disease 16 | 1,893
primary pancreatic ductal adenocarcinoma 16 | 1,271
medulloblastoma 14 | 1,524
juvenile dermatomyositis 13 | 1,189
non-small cell lung cancer 13 | 2,798
sonic hedgehog group medulloblastoma 13 | 1,482
tuberculosis 13 | 1,557
ulcerative colitis 13 | 2,087
Multiple myeloma 12 | 1,327
breast carcinoma 12 | 1,614
ductal carcinoma in situ 12 | 1,745
adult high grade glioma 11 | 2,148
group 3 medulloblastoma 11 | 2,254
Rheumatoid Arthritis 10 | 1,160
acute quadriplegic myopathy 10 | 1,157
astrocytoma 10 | 1,493
diabetes mellitus 10 | 1,663
pituitary cancer 10 | 1,972
progressive supranuclear palsy 10 | 674
group 4 medulloblastoma 9 | 1,875
interstitial cystitis 9 | 2,299
posterior fossa group A ependymoma 9 | 1,511
Intellectual disability 8 | 573
Prostatic Neoplasms 8 | 471
adrenocortical carcinoma 8 | 1,427
atypical teratoid/rhabdoid tumor 8 | 1,095
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
Alzheimer's disease 7 | 644
Endometriosis 7 | 535
Schizophrenia 7 | 501
acute myeloid leukemia 7 | 780
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 499
cystic fibrosis 7 | 1,665
dermatomyositis 7 | 933
non primary Sjogren syndrome sicca 7 | 840
Bipolar Disorder 6 | 266
Chronic Lymphocytic Leukemia 6 | 242
Duchenne muscular dystrophy 6 | 602
IGA Glomerulonephritis 6 | 454
Multiple Sclerosis 6 | 498
Obesity 6 | 616
chronic rhinosinusitis 6 | 512
nasopharyngeal carcinoma 6 | 1,056
primary Sjogren syndrome 6 | 789
spina bifida 6 | 1,064
Atopic dermatitis 5 | 944
Autistic Disorder 5 | 320
Colorectal Neoplasms 5 | 217
Lung Neoplasms 5 | 171
Waldenstrons macroglobulinemia 5 | 765
colon cancer 5 | 1,475
pancreatic carcinoma 5 | 567
posterior fossa group B ependymoma 5 | 1,530
Aortic aneurysm 4 | 34
Bladder Neoplasm 4 | 109
Cerebrovascular disease 4 | 231
Down syndrome 4 | 548
Liver carcinoma 4 | 217
Microcephaly 4 | 149
Neoplasm Metastasis 4 | 138
Osteogenesis imperfecta 4 | 34
Pancreatic Neoplasm 4 | 79
Renal Cell Carcinoma 4 | 199
Retinitis pigmentosa 4 | 153
Stomach Neoplasms 4 | 282
active Crohn's disease 4 | 918
active ulcerative colitis 4 | 477
gastric carcinoma 4 | 832
non-small cell lung carcinoma 4 | 413
Coronary artery disease 3 | 240
Heart disease 3 | 279
Peripheral Neuropathy 3 | 303
esophageal adenocarcinoma 3 | 737
fibroadenoma 3 | 557
mucosa-associated lymphoid tissue lymphoma 3 | 480

Tissue

Blood and immune system 95 | 17,995
Cardiovascular System 95 | 17,958
Digestive Tract 95 | 18,473
Endocrine System 95 | 18,512
Female tissues 95 | 18,647
Liver and Pancreas 95 | 18,136
Male tissues 95 | 17,969
Nervous System 95 | 18,561
Respiratory system 95 | 17,484
Urinary Tract 95 | 18,444
Skin and soft tissues 94 | 18,115

Target Family

Non-IDG 59 | 11,971
Enzyme 19 | 4,146
Kinase 6 | 634
Transcription Factor 6 | 1,400
Epigenetic 3 | 242
Ion Channel 1 | 341
Nuclear Receptor 1 | 48
Transporter 1 | 473

GO Function

protein complex binding 96 | 96
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Nuclear autoantigenic sperm protein NASP Tbio Non-IDG -1.72078 58.3 103
Striatin STRN Tbio Non-IDG -1.63637 51.0 118
Tubby protein homolog TUB Tbio Transcription Factor -2.38823 263.8 53
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 Tclin Enzyme -0.98863 9.92 138
Inhibitor of growth protein 2 ING2 Tbio Epigenetic -1.47891 33.6 155
DEP domain-containing protein 5 DEPDC5 Tbio Non-IDG -1.42040 27.8 40
Abl interactor 1 ABI1 Tbio Non-IDG -1.96839 102.6 251
Peptidyl-prolyl cis-trans isomerase B PPIB Tchem Enzyme -2.21802 177.2 242
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 GNB2 Tbio Non-IDG -0.43889 2.98 102