Development Level

Tbio 168 | 11,445
Tchem 39 | 1,598
Tclin 20 | 613
Tdark 4 | 6,588

IMPC Phenotype

preweaning lethality, complete... 35 | 979
embryonic lethality prior to t... 12 | 278
abnormal behavior 8 | 298
embryonic lethality prior to o... 8 | 239
hypoactivity 7 | 132
abnormal bone structure 6 | 187
abnormal embryo size 6 | 220
abnormal heart morphology 6 | 162
decreased bone mineral content 6 | 151
decreased total body fat amoun... 6 | 207
abnormal seminal vesicle morph... 5 | 114
decreased body weight 5 | 161
decreased vertical activity 5 | 208
increased mean corpuscular vol... 5 | 92
preweaning lethality, incomple... 5 | 499
small testis 5 | 58
decreased body length 4 | 101
decreased bone mineral density 4 | 126
enlarged heart 4 | 210
hyperactivity 4 | 148
short tibia 4 | 97
abnormal kidney morphology 3 | 65
abnormal limb bud morphology 3 | 17
abnormal neural tube closure 3 | 46
abnormal testis morphology 3 | 43
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
decreased circulating total pr... 3 | 49
decreased grip strength 3 | 116
decreased lean body mass 3 | 135
edema 3 | 59
embryonic growth retardation 3 | 106
enlarged spleen 3 | 41
impaired glucose tolerance 3 | 75
improved glucose tolerance 3 | 79
increased body weight 3 | 25
increased bone mineral content 3 | 108
increased circulating chloride... 3 | 41
increased circulating sodium l... 3 | 71
increased lean body mass 3 | 172
increased total body fat amoun... 3 | 134
pallor 3 | 34
prenatal lethality prior to he... 3 | 87
tremors 3 | 39
abnormal allantois morphology 2 | 8
abnormal coat- hair morphology 2 | 19
abnormal coat-hair pigmentatio... 2 | 64
abnormal embryo turning 2 | 31
abnormal heart looping 2 | 5
abnormal midbrain development 2 | 20
abnormal neural tube morpholog... 2 | 12
abnormal pericardium morpholog... 2 | 26
abnormal pharyngeal arch morph... 2 | 8
abnormal skin morphology 2 | 50
abnormal sleep behavior 2 | 70
abnormal tail bud morphology 2 | 8
abnormal tail morphology 2 | 25
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating fructosa... 2 | 30
decreased circulating triglyce... 2 | 79
decreased exploration in new e... 2 | 11
decreased fasted circulating g... 2 | 65
decreased hemoglobin content 2 | 68
decreased lactate dehydrogenas... 2 | 16
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased total retina thickne... 2 | 17
enlarged heart atrium 2 | 4
hemorrhage 2 | 23
increased bone mineral density 2 | 72
increased cardiac muscle contr... 2 | 8
increased circulating alkaline... 2 | 122
increased circulating phosphat... 2 | 26
increased circulating triglyce... 2 | 42
increased hematocrit 2 | 46
increased mean corpuscular hem... 2 | 36
increased red blood cell distr... 2 | 34
pale yolk sac 2 | 25
prenatal lethality 2 | 28
vertebral fusion 2 | 23
abnormal cornea morphology 1 | 31
abnormal heart left ventricle ... 1 | 16
abnormal lung morphology 1 | 26
abnormal retina morphology 1 | 71
abnormal retinal inner nuclear... 1 | 8
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
absent vibrissae 1 | 12
decreased red blood cell distr... 1 | 41
increased aggression 1 | 4
increased anti-nuclear antigen... 1 | 19
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased startle reflex 1 | 112
microphthalmia 1 | 26
thrombocytosis 1 | 27

Disease

Carcinoma 154 | 11,493
ovarian cancer 141 | 8,520
osteosarcoma 120 | 7,950
glioblastoma 97 | 5,792
psoriasis 90 | 6,694
medulloblastoma, large-cell 86 | 6,241
lung cancer 81 | 4,740
atypical teratoid / rhabdoid tumor 77 | 5,112
ependymoma 73 | 4,679
Cancer 71 | 2,499
group 3 medulloblastoma 61 | 4,104
Breast cancer 59 | 3,578
adult high grade glioma 57 | 3,801
oligodendroglioma 51 | 2,850
Kidney cancer 49 | 2,613
malignant mesothelioma 49 | 3,232
subependymal giant cell astrocytoma 49 | 2,287
Astrocytoma, Pilocytic 44 | 3,081
astrocytic glioma 44 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 43 | 3,291
lung adenocarcinoma 43 | 2,716
lung carcinoma 43 | 2,843
Autosomal recessive predisposition 42 | 1,442
invasive ductal carcinoma 42 | 2,951
primitive neuroectodermal tumor 41 | 3,035
Multiple myeloma 39 | 1,332
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,989
pancreatic cancer 37 | 2,398
non-small cell lung cancer 36 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 35 | 2,955
astrocytoma 34 | 1,146
diabetes mellitus 34 | 1,728
breast carcinoma 33 | 1,638
Schizophrenia 31 | 1,160
ulcerative colitis 30 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 28 | 1,962
pituitary cancer 28 | 1,972
Pick disease 27 | 1,894
Muscle hypotonia 25 | 571
tuberculosis 25 | 2,010
Epilepsy 24 | 792
Intellectual disability 24 | 1,016
Liver Cirrhosis, Experimental 24 | 769
ductal carcinoma in situ 24 | 1,745
juvenile dermatomyositis 24 | 1,187
primary pancreatic ductal adenocarcinoma 24 | 1,109
Short stature 23 | 531
adrenocortical carcinoma 23 | 1,428
Cognitive delay 22 | 608
Global developmental delay 22 | 608
Mental and motor retardation 22 | 608
Seizures 22 | 596
acute quadriplegic myopathy 22 | 1,158
group 4 medulloblastoma 22 | 1,855
interstitial cystitis 22 | 2,312
colon cancer 21 | 1,478
Failure to gain weight 20 | 365
Pediatric failure to thrive 20 | 365
Obesity 19 | 678
Prostatic Neoplasms 19 | 495
cystic fibrosis 19 | 1,696
Alzheimer's disease 18 | 658
Rheumatoid arthritis 18 | 1,191
Waldenstrons macroglobulinemia 18 | 765
spina bifida 18 | 1,074
Bipolar Disorder 17 | 666
Melanoma 17 | 711
Stomach Neoplasms 17 | 300
acute myeloid leukemia 17 | 783
dermatomyositis 17 | 966
Duchenne muscular dystrophy 16 | 601
Dull intelligence 16 | 645
Low intelligence 16 | 645
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Poor school performance 16 | 645
Strabismus 16 | 270
cutaneous lupus erythematosus 16 | 1,057
non primary Sjogren syndrome sicca 16 | 891
primary Sjogren syndrome 16 | 735
Carcinoma, Hepatocellular 14 | 228
Hepatomegaly 14 | 285
Liver carcinoma 14 | 240
Sensorineural Hearing Loss (disorder) 14 | 284
Small head 14 | 374
Attention deficit hyperactivity disorder 13 | 278
Blepharoptosis 13 | 231
Breast Neoplasms 13 | 445
Byzanthine arch palate 13 | 194
Cataract 13 | 297
Cryptorchidism 13 | 296
Kidney disease 13 | 430
Lung Neoplasms 13 | 232
Parkinson's disease 13 | 392
pediatric high grade glioma 13 | 1,064
Broad flat nasal bridge 12 | 236
Endometriosis 12 | 540
Nystagmus 12 | 317
autosomal dominant Emery-Dreifuss muscular dystrophy 12 | 510
esophageal adenocarcinoma 12 | 737

Tissue

Liver and Pancreas 229 | 16,750
Digestive Tract 228 | 17,369
Endocrine System 228 | 18,159
Urinary Tract 226 | 16,678
Female tissues 225 | 17,400
Skin and soft tissues 225 | 17,230
Blood and immune system 224 | 16,909
Male tissues 224 | 17,142
Respiratory system 223 | 16,393
Nervous System 222 | 16,725
Cardiovascular System 217 | 15,192

Target Family

Non-IDG 138 | 12,091
Enzyme 43 | 4,145
Transcription Factor 16 | 1,400
Kinase 14 | 634
Epigenetic 6 | 242
Transporter 5 | 473
Nuclear Receptor 4 | 48
GPCR 3 | 408
Ion Channel 2 | 344

GO Function

protein complex binding 231 | 231
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Metastasis-associated protein MTA3 MTA3 Tbio Transcription Factor -1.36174 24.5 204
Nuclear mitotic apparatus protein 1 NUMA1 Tbio Non-IDG -2.76544 575.8 235
Phosphate carrier protein, mitochondrial SLC25A3 Tbio Transporter -2.85426 703.4 33
Adherens junction-associated protein 1 AJAP1 Tbio Non-IDG -1.20907 21.2 25
Telomere length regulation protein TEL2 homolog TELO2 Tbio Non-IDG -0.93554 9.48 94
CD2-associated protein CD2AP Tbio Non-IDG -3.44533 2735.9 82
Beclin-2 BECN2 Tbio Non-IDG 0.00000 87
Neuroendocrine convertase 2 PCSK2 Tchem Enzyme -2.00248 109.8 132
BTB/POZ domain-containing protein KCTD5 KCTD5 Tbio Non-IDG -1.70628 50.2 52
Peroxisome assembly factor 2 PEX6 Tbio Enzyme -1.89379 79.8 148