Development Level

Tbio 75 | 11,445
Tchem 3 | 1,598
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 6 | 499
enlarged heart 4 | 210
preweaning lethality, complete... 4 | 979
abnormal heart morphology 3 | 162
hyperactivity 3 | 148
abnormal eye morphology 2 | 68
abnormal seminal vesicle morph... 2 | 114
decreased circulating aspartat... 2 | 34
decreased vertical activity 2 | 208
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal kidney morphology 1 | 65
abnormal skin morphology 1 | 50
abnormal vibrissa morphology 1 | 25
anophthalmia 1 | 33
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating lactate ... 1 | 3
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased circulating total pr... 1 | 49
decreased grip strength 1 | 116
decreased lactate dehydrogenas... 1 | 16
decreased total body fat amoun... 1 | 207
dilated heart left ventricle 1 | 11
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
fusion of vertebral arches 1 | 7
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 36
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
male infertility 1 | 123
short tibia 1 | 97
thrombocytopenia 1 | 56
vertebral fusion 1 | 23
vertebral transformation 1 | 12

Disease

Carcinoma 56 | 11,493
ovarian cancer 40 | 8,520
lung cancer 37 | 4,740
osteosarcoma 34 | 7,950
glioblastoma 32 | 5,792
psoriasis 32 | 6,694
medulloblastoma, large-cell 28 | 6,241
adult high grade glioma 27 | 3,801
malignant mesothelioma 27 | 3,232
atypical teratoid / rhabdoid tumor 25 | 5,112
Cancer 23 | 2,499
ependymoma 22 | 4,679
Astrocytoma, Pilocytic 20 | 3,081
Breast cancer 20 | 3,578
Kidney cancer 20 | 2,613
non-small cell lung cancer 20 | 2,890
oligodendroglioma 20 | 2,850
Autosomal recessive predisposition 19 | 1,442
group 3 medulloblastoma 19 | 4,104
lung adenocarcinoma 19 | 2,716
pancreatic cancer 19 | 2,398
lung carcinoma 18 | 2,843
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
invasive ductal carcinoma 16 | 2,951
colon cancer 15 | 1,478
pituitary cancer 15 | 1,972
primitive neuroectodermal tumor 15 | 3,035
cystic fibrosis 14 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
Pick disease 13 | 1,894
ulcerative colitis 13 | 1,819
astrocytic glioma 12 | 2,597
breast carcinoma 12 | 1,638
ductal carcinoma in situ 12 | 1,745
spina bifida 12 | 1,074
interstitial cystitis 11 | 2,312
subependymal giant cell astrocytoma 11 | 2,287
cutaneous lupus erythematosus 10 | 1,057
tuberculosis 10 | 2,010
Liver cancer 9 | 604
dermatomyositis 9 | 966
esophageal adenocarcinoma 9 | 737
group 4 medulloblastoma 9 | 1,855
pediatric high grade glioma 9 | 1,064
adrenocortical carcinoma 8 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
primary pancreatic ductal adenocarcinoma 8 | 1,109
Duchenne muscular dystrophy 7 | 601
Intellectual disability 7 | 1,016
Melanoma 7 | 711
Schizophrenia 7 | 1,160
Skin cancer 7 | 469
diabetes mellitus 7 | 1,728
juvenile dermatomyositis 7 | 1,187
nasopharyngeal carcinoma 7 | 1,058
Alzheimer's disease 6 | 658
Down syndrome 6 | 499
Heart disease 6 | 306
Neurodegenerative disease 6 | 414
active ulcerative colitis 6 | 764
astrocytoma 6 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
Amyotrophic lateral sclerosis 5 | 451
Atopic dermatitis 5 | 952
Dull intelligence 5 | 645
Endometrial cancer 5 | 311
Glaucoma 5 | 239
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Poor school performance 5 | 645
Rheumatoid arthritis 5 | 1,191
Short stature 5 | 531
Spontaneous abortion 5 | 113
Waldenstrons macroglobulinemia 5 | 765
active Crohn's disease 5 | 922
acute myeloid leukemia 5 | 783
acute quadriplegic myopathy 5 | 1,158
gastric carcinoma 5 | 807
non primary Sjogren syndrome sicca 5 | 891
Atherosclerosis 4 | 291
Cardiovascular system disease 4 | 246
Cataract 4 | 297
Cleft Palate 4 | 271
Heart failure 4 | 162
Hypertrophic Cardiomyopathy 4 | 117
Hypoplastic mandible condyle 4 | 275
Mandibular hypoplasia 4 | 275
Micrognathism 4 | 275
Multiple Sclerosis 4 | 540
Muscle Spasticity 4 | 195
Osteoporosis 4 | 363
Prostatic Neoplasms 4 | 495
Squamous cell carcinoma 4 | 129
aldosterone-producing adenoma 4 | 665
atypical teratoid/rhabdoid tumor 4 | 357
nephrosclerosis 4 | 333
primary Sjogren syndrome 4 | 735
sarcoidosis 4 | 370

Tissue

Blood and immune system 80 | 16,909
Female tissues 80 | 17,400
Skin and soft tissues 80 | 17,230
Digestive Tract 79 | 17,369
Endocrine System 79 | 18,159
Liver and Pancreas 78 | 16,750
Male tissues 78 | 17,142
Urinary Tract 77 | 16,678
Nervous System 76 | 16,725
Respiratory system 76 | 16,393
Cardiovascular System 73 | 15,192

Target Family

Non-IDG 67 | 12,091
Enzyme 10 | 4,145
Epigenetic 2 | 242
Transporter 1 | 473

GO Function

protein binding, bridging 80 | 80
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable ergosterol biosynthetic protein 28 ERG28 Tdark Non-IDG -1.25331 16.7 40
E3 ubiquitin-protein ligase AMFR AMFR Tbio Enzyme -2.46909 292.8 203
Centlein CNTLN Tbio Non-IDG -2.28518 122.3 76
Leucine-rich repeat transmembrane protein FLRT2 FLRT2 Tbio Non-IDG -1.09240 12.6 50
RNA-binding protein 14 RBM14 Tbio Non-IDG -2.10043 124.7 168
Ankyrin-2 ANK2 Tbio Non-IDG -2.08421 120.5 236
Death domain-containing protein CRADD CRADD Tbio Non-IDG -1.34614 23.0 400
Immunoglobulin J chain JCHAIN Tbio Non-IDG -2.58576 355.8 218
Collagen alpha-1(XI) chain COL11A1 Tbio Non-IDG -2.15516 138.4 96
Protein KIBRA WWC1 Tbio Non-IDG -1.96854 92.8 130