Development Level

Tbio 79 | 11,445
Tchem 22 | 1,598
Tclin 4 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 15 | 979
embryonic lethality prior to o... 5 | 239
preweaning lethality, incomple... 5 | 499
decreased fasted circulating g... 3 | 65
embryonic lethality prior to t... 3 | 278
abnormal behavior 2 | 298
abnormal behavioral response t... 2 | 66
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
abnormal lens morphology 2 | 81
absent pinna reflex 2 | 23
cataract 2 | 92
decreased body weight 2 | 161
decreased bone mineral density 2 | 126
decreased mean corpuscular hem... 2 | 50
decreased total body fat amoun... 2 | 207
increased circulating sodium l... 2 | 71
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
persistence of hyaloid vascula... 2 | 33
abnormal bone mineralization 1 | 38
abnormal embryo turning 1 | 31
abnormal locomotor activation 1 | 16
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal inner nuclear... 1 | 8
abnormal retinal vasculature m... 1 | 27
abnormal tooth morphology 1 | 24
cardiovascular system phenotyp... 1 | 36
convulsive seizures 1 | 13
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating creatine... 1 | 4
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating creatine... 1 | 5
increased circulating glycerol... 1 | 9
increased circulating potassiu... 1 | 29
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 36
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
prenatal lethality prior to he... 1 | 87
stereotypic behavior 1 | 3
trunk curl 1 | 16
vertebral transformation 1 | 12

Disease

Carcinoma 65 | 11,493
ovarian cancer 57 | 8,520
lung cancer 48 | 4,740
osteosarcoma 47 | 7,950
Cancer 44 | 2,499
medulloblastoma, large-cell 43 | 6,241
psoriasis 38 | 6,694
glioblastoma 34 | 5,792
atypical teratoid / rhabdoid tumor 31 | 5,112
ependymoma 27 | 4,679
group 3 medulloblastoma 27 | 4,104
malignant mesothelioma 27 | 3,232
Intellectual disability 24 | 1,016
adult high grade glioma 23 | 3,801
oligodendroglioma 23 | 2,850
pancreatic cancer 23 | 2,398
diabetes mellitus 22 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,291
Autosomal recessive predisposition 21 | 1,442
Epilepsy 21 | 792
primitive neuroectodermal tumor 21 | 3,035
Seizures 20 | 596
Breast cancer 19 | 3,578
Cognitive delay 18 | 608
Global developmental delay 18 | 608
Mental and motor retardation 18 | 608
Short stature 18 | 531
astrocytoma 18 | 1,146
Dull intelligence 17 | 645
Low intelligence 17 | 645
Mental Retardation 17 | 645
Mental deficiency 17 | 645
Poor school performance 17 | 645
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
invasive ductal carcinoma 17 | 2,951
Failure to gain weight 16 | 365
Pediatric failure to thrive 16 | 365
Pick disease 16 | 1,894
Small head 16 | 374
Strabismus 16 | 270
astrocytic glioma 16 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
tuberculosis 16 | 2,010
Astrocytoma, Pilocytic 15 | 3,081
Kidney cancer 15 | 2,613
Multiple myeloma 15 | 1,332
Rheumatoid arthritis 15 | 1,191
Schizophrenia 15 | 1,160
non-small cell lung cancer 15 | 2,890
Cerebellar Ataxia 14 | 304
Cryptorchidism 14 | 296
adrenocortical carcinoma 14 | 1,428
juvenile dermatomyositis 14 | 1,187
subependymal giant cell astrocytoma 14 | 2,287
Cataract 13 | 297
Melanoma 13 | 711
Muscle hypotonia 13 | 571
Waldenstrons macroglobulinemia 13 | 765
acute quadriplegic myopathy 13 | 1,158
lung carcinoma 13 | 2,843
Electroencephalogram abnormal 12 | 101
Lens Opacities 12 | 231
Optic Atrophy 12 | 242
Sensorineural Hearing Loss (disorder) 12 | 284
dermatomyositis 12 | 966
lung adenocarcinoma 12 | 2,716
Feeding difficulties in infancy 11 | 175
Hypoplastic mandible condyle 11 | 275
Mandibular hypoplasia 11 | 275
Micrognathism 11 | 275
Muscle Spasticity 11 | 195
Nystagmus 11 | 317
Prostatic Neoplasms 11 | 495
colon cancer 11 | 1,478
Breast Neoplasms 10 | 445
Concave bridge of nose 10 | 195
Depressed nasal bridge 10 | 195
Depressed nasal root/bridge 10 | 195
Developmental regression 10 | 95
Loss of developmental milestones 10 | 95
Mammary Neoplasms 10 | 425
Mental deterioration in childhood 10 | 95
Neurodevelopmental regression 10 | 95
Psychomotor regression 10 | 95
Psychomotor regression beginning in infancy 10 | 95
Psychomotor regression in infants 10 | 95
Psychomotor regression, progressive 10 | 95
Squamous cell carcinoma 10 | 129
pituitary cancer 10 | 1,972
ulcerative colitis 10 | 1,819
Acquired scoliosis 9 | 281
Anemia 9 | 365
Broad flat nasal bridge 9 | 236
Curvature of spine 9 | 282
Infant, Small for Gestational Age 9 | 176
Intrauterine retardation 9 | 176
Nasal bridge wide 9 | 236
breast carcinoma 9 | 1,638
ductal carcinoma in situ 9 | 1,745

Tissue

Digestive Tract 105 | 17,369
Endocrine System 105 | 18,159
Blood and immune system 103 | 16,909
Female tissues 103 | 17,400
Skin and soft tissues 103 | 17,230
Liver and Pancreas 102 | 16,750
Male tissues 102 | 17,142
Nervous System 102 | 16,725
Respiratory system 101 | 16,393
Urinary Tract 100 | 16,678
Cardiovascular System 99 | 15,192

Target Family

Non-IDG 64 | 12,091
Enzyme 15 | 4,145
Transcription Factor 11 | 1,400
Epigenetic 8 | 242
Kinase 4 | 634
GPCR 1 | 408
Ion Channel 1 | 344
TF/Epigenetic 1 | 38
Transporter 1 | 473

GO Function

protein N-terminus binding 106 | 106
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Huntingtin-interacting protein K HYPK Tbio Non-IDG -0.84672 8.89 4
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
Sec1 family domain-containing protein 1 SCFD1 Tbio Non-IDG -1.50460 33.8 170
Unconventional myosin-VIIa MYO7A Tbio Non-IDG -2.14713 133.5 129
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Peroxisomal targeting signal 1 receptor PEX5 Tbio Non-IDG -2.43126 272.8 138
Heat shock 70 kDa protein 1A HSPA1B Tchem Non-IDG -3.10995 0.00000 1174
Heat shock 70 kDa protein 1B HSPA1B Tbio Non-IDG -1.61862 0.00000 60
Eukaryotic translation initiation factor 5A-1 EIF5A Tbio Non-IDG -2.10288 142.0 231
General transcription factor IIH subunit 2 GTF2H2 Tbio Non-IDG -1.32757 20.2 148