Development Level

Tbio 27 | 11,445
Tchem 4 | 1,598
Tclin 1 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 5 | 499
abnormal embryo size 3 | 220
decreased body length 2 | 101
embryonic lethality prior to t... 2 | 278
male infertility 2 | 123
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal craniofacial morpholo... 1 | 33
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
absent seminal vesicle 1 | 4
anophthalmia 1 | 33
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased lean body mass 1 | 135
decreased lumbar vertebrae num... 1 | 2
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged lymph nodes 1 | 37
female infertility 1 | 60
hemorrhage 1 | 23
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased CD4-positive, alpha ... 1 | 4
increased circulating triglyce... 1 | 42
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
microphthalmia 1 | 26
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small uterus 1 | 3

Disease

Carcinoma 29 | 11,493
medulloblastoma, large-cell 20 | 6,241
ovarian cancer 20 | 8,520
Cancer 19 | 2,499
osteosarcoma 19 | 7,950
psoriasis 17 | 6,694
glioblastoma 15 | 5,792
lung cancer 14 | 4,740
atypical teratoid / rhabdoid tumor 12 | 5,112
group 3 medulloblastoma 12 | 4,104
Kidney cancer 11 | 2,613
Breast cancer 10 | 3,578
ependymoma 10 | 4,679
pancreatic cancer 9 | 2,398
adult high grade glioma 8 | 3,801
invasive ductal carcinoma 8 | 2,951
oligodendroglioma 8 | 2,850
astrocytic glioma 7 | 2,597
breast carcinoma 7 | 1,638
cystic fibrosis 7 | 1,696
lung adenocarcinoma 7 | 2,716
malignant mesothelioma 7 | 3,232
non-small cell lung cancer 7 | 2,890
primitive neuroectodermal tumor 7 | 3,035
Astrocytoma, Pilocytic 6 | 3,081
adrenocortical carcinoma 6 | 1,428
group 4 medulloblastoma 6 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
Congenital hypoplasia of penis 5 | 176
Intellectual disability 5 | 1,016
Multiple myeloma 5 | 1,332
Rheumatoid arthritis 5 | 1,191
Schizophrenia 5 | 1,160
acute quadriplegic myopathy 5 | 1,158
diabetes mellitus 5 | 1,728
hearing impairment 5 | 199
interstitial cystitis 5 | 2,312
pituitary cancer 5 | 1,972
tuberculosis 5 | 2,010
ulcerative colitis 5 | 1,819
Cryptorchidism 4 | 296
Depressive disorder 4 | 409
Dull intelligence 4 | 645
Epilepsy 4 | 792
Low intelligence 4 | 645
MYELODYSPLASTIC SYNDROME 4 | 53
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Muscle Spasticity 4 | 195
Nystagmus 4 | 317
Poor school performance 4 | 645
Prostatic Neoplasms 4 | 495
Sensorineural Hearing Loss (disorder) 4 | 284
astrocytoma 4 | 1,146
dermatomyositis 4 | 966
ductal carcinoma in situ 4 | 1,745
gastric cancer 4 | 459
juvenile dermatomyositis 4 | 1,187
lung carcinoma 4 | 2,843
nasopharyngeal carcinoma 4 | 1,058
pancreatic carcinoma 4 | 562
primary pancreatic ductal adenocarcinoma 4 | 1,109
spina bifida 4 | 1,074
Atopic dermatitis 3 | 952
Cataract 3 | 297
Cognitive delay 3 | 608
Concave bridge of nose 3 | 195
Congenital deafness 3 | 185
Congenital heart disease 3 | 93
Deafness 3 | 198
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Down syndrome 3 | 499
Glaucoma 3 | 239
Global developmental delay 3 | 608
Hearing Loss, Partial 3 | 185
Highly variable clinical phenotype 3 | 150
Highly variable phenotype and severity 3 | 150
Highly variable phenotype, even within families 3 | 150
Hypogonadism 3 | 173
Hypotrophic malar bone 3 | 129
Lens Opacities 3 | 231
Lymphopenia 3 | 67
Malar flattening 3 | 129
Melanoma 3 | 711
Mental and motor retardation 3 | 608
Muscle hypotonia 3 | 571
Osteoporosis 3 | 363
Patent ductus arteriosus 3 | 90
Phenotypic variability 3 | 150
Seizures 3 | 596
Tetralogy of Fallot 3 | 63
Umbilical hernia 3 | 93
Waldenstrons macroglobulinemia 3 | 765
colon cancer 3 | 1,478
gastric carcinoma 3 | 807
non primary Sjogren syndrome sicca 3 | 891
primary Sjogren syndrome 3 | 735

Tissue

Endocrine System 33 | 18,159
Blood and immune system 32 | 16,909
Digestive Tract 32 | 17,369
Female tissues 32 | 17,400
Liver and Pancreas 32 | 16,750
Male tissues 32 | 17,142
Nervous System 32 | 16,725
Skin and soft tissues 32 | 17,230
Urinary Tract 32 | 16,678
Cardiovascular System 31 | 15,192
Respiratory system 31 | 16,393

Target Family

Transcription Factor 15 | 1,400
Non-IDG 8 | 12,091
Enzyme 4 | 4,145
Epigenetic 4 | 242
TF/Epigenetic 2 | 38

GO Function

promoter-specific chromatin bi... 33 | 33
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable ATP-dependent RNA helicase DDX5 DDX5 Tbio Enzyme -2.08566 121.1 344
Neural retina-specific leucine zipper protein NRL Tbio Transcription Factor -2.46080 279.4 74
Forkhead box protein C2 FOXC2 Tbio Transcription Factor -2.23435 187.0 419
Zinc finger protein 304 ZNF304 Tbio Transcription Factor -0.83471 4.32 16
DNA (cytosine-5)-methyltransferase 1 DNMT1 Tclin Enzyme -3.21333 1562.7 1125
Heterogeneous nuclear ribonucleoprotein U HNRNPU Tbio Non-IDG -2.33813 207.8 169
Krueppel-like factor 4 KLF4 Tbio Transcription Factor -2.89447 774.1 686
POU domain, class 4, transcription factor 2 POU4F2 Tbio Transcription Factor -1.94397 90.2 145
Zinc finger protein 750 ZNF750 Tbio Non-IDG -1.00843 12.4 86
ATP-dependent RNA helicase A DHX9 Tbio Enzyme -2.85807 734.3 204