Development Level

Tbio 9 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

embryonic lethality prior to t... 2 | 278
pallor 2 | 34
prenatal lethality prior to he... 2 | 87
abnormal allantois morphology 1 | 8
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal coat appearance 1 | 31
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal retinal inner nuclear... 1 | 8
abnormal sleep behavior 1 | 70
abnormal vertebrae morphology 1 | 18
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased heart left ventricle... 1 | 28
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
increased bone mineral content 1 | 108
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
prolonged PR interval 1 | 15
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
thin ventricular wall 1 | 24

Disease

Carcinoma 8 | 11,493
ovarian cancer 6 | 8,520
psoriasis 6 | 6,694
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
malignant mesothelioma 5 | 3,232
osteosarcoma 5 | 7,950
Liver Cirrhosis, Experimental 4 | 769
Kidney cancer 3 | 2,613
Pick disease 3 | 1,894
ependymoma 3 | 4,679
glioblastoma 3 | 5,792
group 4 medulloblastoma 3 | 1,855
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
invasive ductal carcinoma 3 | 2,951
lung cancer 3 | 4,740
lung carcinoma 3 | 2,843
medulloblastoma, large-cell 3 | 6,241
pancreatic cancer 3 | 2,398
subependymal giant cell astrocytoma 3 | 2,287
Alzheimer's disease 2 | 658
Astrocytoma, Pilocytic 2 | 3,081
Atrophy of cerebellum 2 | 103
Autosomal recessive predisposition 2 | 1,442
Bipolar Disorder 2 | 666
Breast cancer 2 | 3,578
Cancer 2 | 2,499
Cerebellar degeneration 2 | 103
Cerebral atrophy 2 | 178
Dementia 2 | 175
Depressive disorder 2 | 409
Endometrial cancer 2 | 311
Epilepsy 2 | 792
Hyperreflexia 2 | 209
Infratentorial atrophy 2 | 103
Intellectual disability 2 | 1,016
Liver cancer 2 | 604
Long palpebral fissure 2 | 17
Long philtrum 2 | 137
Mental Depression 2 | 333
Muscle Spasticity 2 | 195
Neurodegenerative disease 2 | 414
Seizures 2 | 596
Waldenstrons macroglobulinemia 2 | 765
adult high grade glioma 2 | 3,801
astrocytic glioma 2 | 2,597
atypical teratoid / rhabdoid tumor 2 | 5,112
cutaneous lupus erythematosus 2 | 1,057
ductal carcinoma in situ 2 | 1,745
hepatocellular carcinoma 2 | 547
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primitive neuroectodermal tumor 2 | 3,035
ulcerative colitis 2 | 1,819
Animal Mammary Neoplasms 1 | 136
Axial hypotonia 1 | 46
Bleeding time prolonged 1 | 31
Breast Neoplasms 1 | 445
Chronic otitis media 1 | 52
Colorectal Neoplasms 1 | 243
Congenital deafness 1 | 185
Craniofacial Abnormalities 1 | 151
DOID:2627 1 | 94
Deafness 1 | 198
Decreased platelet count 1 | 111
Degenerative brain disorder 1 | 100
Dyspnea 1 | 76
ENSP00000256078 1 | 30
Ecchymosis 1 | 66
Fatigue 1 | 182
Fever 1 | 138
Gaucher disease type 1 1 | 180
Hearing Loss, Partial 1 | 185
Hypersplenism 1 | 10
Immunologic Deficiency Syndromes 1 | 113
Increased tendency to bruise 1 | 66
Lymphoid leukemia 1 | 160
Lymphopenia 1 | 67
Mammary Neoplasms 1 | 425
Mammary Neoplasms, Animal 1 | 136
Mammary Neoplasms, Experimental 1 | 154
Nonsyndromic deafness 1 | 142
Platelet morphology abnormal 1 | 9
Pointed chin 1 | 33
Pontine hypoplasia 1 | 7
Portal hypertension 1 | 20
Purpura 1 | 43
Recurrent respiratory infections 1 | 141
Sensorineural hearing loss 1 | 106
Squamous cell carcinoma 1 | 129
Supratentorial atrophy 1 | 94
Thin upper lip vermilion 1 | 67
Thrombocytopenia 1 | 197
Weight decreased 1 | 103
ear infection chronic 1 | 52
hearing impairment 1 | 199
interstitial lung disease 1 | 298
sarcoidosis 1 | 370

Tissue

Blood and immune system 10 | 16,909
Cardiovascular System 10 | 15,192
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678

Target Family

Non-IDG 9 | 12,091
Enzyme 1 | 4,145

GO Function

profilin binding 10 | 10
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Huntingtin HTT Tchem Non-IDG -3.36282 2294.8 599
Actin, cytoplasmic 2 ACTG1 Tbio Non-IDG -2.50312 297.3 225
Protein piccolo PCLO Tbio Non-IDG -2.48756 308.4 124
Rho-related GTP-binding protein RhoQ RHOQ Tbio Enzyme -1.48059 28.3 111
Vasodilator-stimulated phosphoprotein VASP Tbio Non-IDG -2.98534 952.6 796
WAS/WASL-interacting protein family member 1 WIPF1 Tbio Non-IDG -2.03820 107.4 108
Ena/VASP-like protein EVL Tbio Non-IDG -2.21334 170.1 137
Src substrate cortactin CTTN Tbio Non-IDG -2.62377 433.2 722
Drebrin DBN1 Tbio Non-IDG -2.10391 152.0 219
Formin-like protein 1 FMNL1 Tbio Non-IDG -1.48467 31.1 114