Development Level

Tbio 2 | 11,445
Tchem 1 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

abnormal seminal vesicle morph... 1 | 114
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
preweaning lethality, incomple... 1 | 499

Disease

osteosarcoma 4 | 7,950
ovarian cancer 4 | 8,520
Carcinoma 3 | 11,493
glioblastoma 3 | 5,792
pancreatic cancer 3 | 2,398
Multiple myeloma 2 | 1,332
astrocytoma 2 | 1,146
atypical teratoid / rhabdoid tumor 2 | 5,112
diabetes mellitus 2 | 1,728
ependymoma 2 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
malignant mesothelioma 2 | 3,232
non-small cell lung cancer 2 | 2,890
pediatric high grade glioma 2 | 1,064
primary pancreatic ductal adenocarcinoma 2 | 1,109
psoriasis 2 | 6,694
Abetalipoproteinemia 1 | 7
Abnormal skeletal development 1 | 60
Abnormality of the metaphyses 1 | 48
Abnormality of the ribs 1 | 32
Abnormality of the voice 1 | 46
Abnormally-shaped vertebrae 1 | 31
Acquired scoliosis 1 | 281
Acrocephaly 1 | 12
Astrocytoma, Pilocytic 1 | 3,081
Blue sclera 1 | 32
Bowing of the long bones 1 | 31
Breast cancer 1 | 3,578
COPD 1 | 118
Cancer 1 | 2,499
Cole Carpenter syndrome 1 | 2
Collapse of vertebra 1 | 14
Communicating Hydrocephalus 1 | 8
Compression fracture of vertebral column 1 | 14
Coronal craniosynostosis 1 | 14
Craniosynostosis 1 | 74
Crohn's disease 1 | 321
Crumpled long bones 1 | 5
Curvature of spine 1 | 282
Decreased projection of midface 1 | 105
Decreased size of teeth 1 | 62
Decreased width of tooth 1 | 59
Defective tooth enamel 1 | 31
Diphtheria 1 | 40
Duchenne muscular dystrophy 1 | 601
Dystrophic tooth enamel 1 | 31
Enamel abnormalities 1 | 31
Exophthalmos 1 | 112
Frequent fractures 1 | 53
Frontal bossing 1 | 157
Generalized osteopenia 1 | 99
High pitched voice 1 | 23
Hyperkyphosis 1 | 111
Hypoplastic mandible condyle 1 | 275
Hypotrophic midface 1 | 105
Increased fracture rate 1 | 53
Inflammatory bowel disease 5 1 | 14
Intrauterine retardation 1 | 176
Kyphosis deformity of spine 1 | 114
Late tooth eruption 1 | 61
Mandibular hypoplasia 1 | 275
Microdontia (disorder) 1 | 59
Midface retrusion 1 | 105
Muscle hypotonia 1 | 571
Myocardial Ischemia 1 | 169
Neurodegenerative disease 1 | 414
Osteochondrodysplasias 1 | 72
Osteogenesis imperfecta 1 | 34
Osteopenia 1 | 99
Osteoporosis 1 | 363
Prominent eyes 1 | 96
Prominent globes 1 | 96
Prostatic Neoplasms 1 | 495
Protruding eyes 1 | 96
Renal clear cell carcinoma 1 | 6
SPINOCEREBELLAR ATAXIA 17 1 | 9
Shallow orbits 1 | 13
Short stature 1 | 531
Small midface 1 | 105
Structure of wormian bone 1 | 24
Varying degree of multiple fractures 1 | 53
X-linked cerebral adrenoleukodystrophy 1 | 116
acute quadriplegic myopathy 1 | 1,158
adrenocortical carcinoma 1 | 1,428
ductal carcinoma in situ 1 | 1,745
fibroadenoma 1 | 559
inflammatory breast cancer 1 | 286
interstitial cystitis 1 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,989
lung cancer 1 | 4,740
oligodendroglioma 1 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,962
pituitary cancer 1 | 1,972
posterior fossa group A ependymoma 1 | 468
primitive neuroectodermal tumor 1 | 3,035
subependymal giant cell astrocytoma 1 | 2,287
tuberculosis 1 | 2,010

Tissue

Blood and immune system 4 | 16,909
Cardiovascular System 4 | 15,192
Digestive Tract 4 | 17,369
Endocrine System 4 | 18,159
Female tissues 4 | 17,400
Liver and Pancreas 4 | 16,750
Male tissues 4 | 17,142
Nervous System 4 | 16,725
Respiratory system 4 | 16,393
Skin and soft tissues 4 | 17,230
Urinary Tract 4 | 16,678

Target Family

Enzyme 4 | 4,145

GO Function

procollagen-proline 4-dioxygen... 4 | 4
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Prolyl 4-hydroxylase subunit alpha-2 P4HA2 Tbio Enzyme -1.04006 10.9 76
Prolyl 4-hydroxylase subunit alpha-1 P4HA1 Tchem Enzyme -1.30977 17.5 172
Prolyl 4-hydroxylase subunit alpha-3 P4HA3 Tdark Enzyme -0.48463 2.86 89
Protein disulfide-isomerase P4HB Tbio Enzyme -3.03189 1042.5 381