Development Level

Tbio 8 | 11,445
Tclin 4 | 613
Tchem 1 | 1,598

IMPC Phenotype

decreased fasted circulating g... 2 | 65
abnormal coat-hair pigmentatio... 1 | 64
abnormal iris transilluminatio... 1 | 2
abnormal retina morphology 1 | 71
decreased prepulse inhibition 1 | 82
enlarged thymus 1 | 5
impaired glucose tolerance 1 | 75
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 10 | 11,493
glioblastoma 10 | 5,792
medulloblastoma, large-cell 10 | 6,241
adult high grade glioma 8 | 3,801
atypical teratoid / rhabdoid tumor 8 | 5,112
osteosarcoma 8 | 7,950
lung cancer 7 | 4,740
ovarian cancer 7 | 8,520
ependymoma 6 | 4,679
group 3 medulloblastoma 4 | 4,104
pituitary cancer 4 | 1,972
primitive neuroectodermal tumor 4 | 3,035
psoriasis 4 | 6,694
subependymal giant cell astrocytoma 4 | 2,287
Autosomal recessive predisposition 3 | 1,442
Cancer 3 | 2,499
Kidney cancer 3 | 2,613
astrocytic glioma 3 | 2,597
group 4 medulloblastoma 3 | 1,855
invasive ductal carcinoma 3 | 2,951
lung adenocarcinoma 3 | 2,716
lung carcinoma 3 | 2,843
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
Anemia 2 | 365
Anteverted nostril 2 | 191
Astrocytoma, Pilocytic 2 | 3,081
Breast cancer 2 | 3,578
Cognitive delay 2 | 608
Diabetes Mellitus, Experimental 2 | 108
Downturned corners of mouth 2 | 48
Dull intelligence 2 | 645
Epilepsy 2 | 792
Global developmental delay 2 | 608
Heart disease 2 | 306
Intellectual disability 2 | 1,016
Low intelligence 2 | 645
Malaria 2 | 160
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Multiple Sclerosis 2 | 540
Multiple myeloma 2 | 1,332
Oculocutaneous albinism 2 | 29
Poor school performance 2 | 645
Seizures 2 | 596
Small head 2 | 374
breast carcinoma 2 | 1,638
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
ductal carcinoma in situ 2 | 1,745
malignant mesothelioma 2 | 3,232
pancreatic cancer 2 | 2,398
tuberculosis 2 | 2,010
Abnormal amniotic fluid 1 | 6
Adenosine Triphosphate, Elevated, Of Erythrocytes 1 | 1
Adrenal cortical adenocarcinoma 1 | 4
Adrenal gland cancer 1 | 12
Amelogenesis Imperfecta hypomaturation type 1 | 7
Bilateral ptosis 1 | 9
Bowed and upward slanting eyebrows 1 | 41
Cholelithiasis 1 | 33
Chronic hemolytic anemia 1 | 3
Congenital hemolytic anemia 1 | 32
Deficiency of pyruvate kinase 1 | 1
Elevated heart rate 1 | 25
Episodic ataxia 1 | 22
Glycosuria 1 | 29
Hyperinsulinaemic hypoglycaemia 1 | 16
Hyperinsulinemic hypoglycemia 1 | 17
Hyperplasia of columella 1 | 4
Hypertensive Emergencies 1 | 10
Hypoketotic hypoglycemia 1 | 11
Hypoplasia of optic disc 1 | 12
Increased red cell osmotic fragility 1 | 4
Insulinoma 1 | 24
Islets of Langerhans hyperplasia 1 | 11
Kernicterus 1 | 11
Large for gestational age 1 | 11
Maturity onset diabetes mellitus in young 1 | 11
Mild global developmental delay 1 | 14
Myasthenia gravis 1 | 23
Prominent metopic ridge 1 | 15
Psychomotor retardation, mild 1 | 14
Pyruvate kinase deficiency of red cells 1 | 1
Reduced erythrocyte 2,3-diphosphoglycerate concentration 1 | 2
Reduced visual acuity 1 | 63
Reticulocytosis 1 | 20
Rosacea 1 | 25
Short hands 1 | 50
Small hand 1 | 36
Thick, flared eyebrows 1 | 41
Thin hypoplastic alae nasi 1 | 51
Thymoma 1 | 16
Tonic - clonic seizures 1 | 44
Type 1 diabetes mellitus 1 | 109
Unconjugated hyperbilirubinemia 1 | 4
Wide columella 1 | 4
Wide spaced nipples 1 | 46
maturity-onset diabetes of the young 1 | 32

Tissue

Endocrine System 13 | 18,159
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Blood and immune system 11 | 16,909
Digestive Tract 11 | 17,369
Respiratory system 11 | 16,393
Cardiovascular System 10 | 15,192

Target Family

Transporter 6 | 473
Kinase 3 | 634
Ion Channel 2 | 344
Enzyme 1 | 4,145
Epigenetic 1 | 242

GO Function

potassium ion binding 13 | 13
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sodium/potassium/calcium exchanger 3 SLC24A3 Tbio Transporter -1.12274 13.0 86
Sodium/potassium/calcium exchanger 2 SLC24A2 Tbio Transporter -1.39605 25.7 32
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
Pyruvate kinase PKM PKM Tchem Kinase -3.15332 1424.2 749
Sodium/potassium/calcium exchanger 4 SLC24A4 Tbio Transporter -1.32054 20.8 63
Pyridoxal kinase PDXK Tbio Kinase -2.47099 287.1 218
Sodium/potassium-transporting ATPase subunit alpha-1 ATP1A1 Tclin Transporter -1.68777 43.2 399
Potassium voltage-gated channel subfamily A member 4 KCNA4 Tclin Ion Channel -2.32803 199.8 155
Sodium/potassium/calcium exchanger 5 SLC24A5 Tbio Transporter -1.63611 43.9 61
Sodium/potassium/calcium exchanger 1 SLC24A1 Tbio Transporter -1.90810 81.5 92