Development Level

Tbio 29 | 11,651
Tclin 6 | 612
Tchem 4 | 1,388

Collection

Ion Channel: IDG Consortium (T... 9 | 99

IMPC Phenotype

preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
absent startle reflex 1 | 24
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
hyperactivity 1 | 148
hypoactivity 1 | 132
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased or absent threshold ... 1 | 101
increased vertical activity 1 | 24

Disease

Carcinoma 23 | 11,493
medulloblastoma, large-cell 22 | 6,241
ependymoma 20 | 4,679
ovarian cancer 20 | 8,520
atypical teratoid / rhabdoid tumor 19 | 5,112
group 3 medulloblastoma 18 | 4,104
oligodendroglioma 18 | 2,850
osteosarcoma 18 | 7,950
glioblastoma 17 | 5,792
psoriasis 16 | 6,694
adult high grade glioma 15 | 3,801
Pick disease 13 | 1,894
astrocytic glioma 13 | 2,597
primitive neuroectodermal tumor 13 | 3,035
lung cancer 12 | 4,740
Astrocytoma, Pilocytic 11 | 3,081
Breast cancer 11 | 3,578
Bipolar Disorder 9 | 666
colon cancer 9 | 1,478
subependymal giant cell astrocytoma 9 | 2,287
ductal carcinoma in situ 8 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
lung carcinoma 8 | 2,843
malignant mesothelioma 8 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
invasive ductal carcinoma 7 | 2,951
Hypertension 6 | 396
Kidney cancer 6 | 2,613
Long QT syndrome 6 | 39
Schizophrenia 6 | 1,160
interstitial cystitis 6 | 2,312
non-small cell lung cancer 6 | 2,890
pituitary cancer 6 | 1,972
Atrial Fibrillation 5 | 124
Attention deficit hyperactivity disorder 5 | 278
Cancer 5 | 2,499
lung adenocarcinoma 5 | 2,716
medulloblastoma 5 | 720
pancreatic cancer 5 | 2,398
Brugada syndrome 4 | 29
Cardiac arrest 4 | 36
Cleft Palate 4 | 271
Concave bridge of nose 4 | 195
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Epilepsy 4 | 792
Intellectual disability 4 | 1,016
Mental Depression 4 | 333
Multiple Sclerosis 4 | 540
Multiple myeloma 4 | 1,332
Parkinson's disease 4 | 392
Seizures 4 | 596
active Crohn's disease 4 | 922
active ulcerative colitis 4 | 764
acute myeloid leukemia 4 | 783
breast carcinoma 4 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
spina bifida 4 | 1,074
ulcerative colitis 4 | 1,819
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 3 | 21
Amyotrophic lateral sclerosis 3 | 451
Anteverted nostril 3 | 191
Atrioventricular block 3 | 35
Autistic Disorder 3 | 364
Broad flat nasal bridge 3 | 236
Cardiomyopathy 3 | 116
Chromosome 1p36 deletion syndrome 3 | 23
Cognitive delay 3 | 608
Congenital Epicanthus 3 | 177
Down syndrome 3 | 499
Downward slant of palpebral fissure 3 | 158
Dull intelligence 3 | 645
Eaton-Lambert syndrome 3 | 40
Gastroesophageal reflux disease 3 | 110
Global developmental delay 3 | 608
Heart disease 3 | 306
Hypertensive disease 3 | 292
Hypertensive disorder 3 | 57
Hypoplastic mandible condyle 3 | 275
Low intelligence 3 | 645
Major Depressive Disorder 3 | 301
Mandibular hypoplasia 3 | 275
Mental Retardation 3 | 645
Mental and motor retardation 3 | 608
Mental deficiency 3 | 645
Micrognathism 3 | 275
Microstomia 3 | 78
Muscle hypotonia 3 | 571
Nasal bridge wide 3 | 236
Orbital separation excessive 3 | 244
Poor school performance 3 | 645
Prolonged QT interval 3 | 15
Romano-Ward Syndrome 3 | 12
Unipolar Depression 3 | 250
Ventricular Fibrillation 3 | 17
adrenocortical carcinoma 3 | 1,428
cystic fibrosis 3 | 1,696
gastric carcinoma 3 | 807
tuberculosis 3 | 2,010

Tissue

Digestive Tract 39 | 17,369
Female tissues 39 | 17,400
Endocrine System 38 | 18,159
Skin and soft tissues 38 | 17,230
Blood and immune system 37 | 16,909
Liver and Pancreas 37 | 16,750
Male tissues 37 | 17,142
Nervous System 37 | 16,725
Respiratory system 37 | 16,393
Cardiovascular System 35 | 15,192
Urinary Tract 35 | 16,678

Target Family

Ion Channel 18 | 344
Non-IDG 8 | 12,091
Enzyme 4 | 4,145
Kinase 4 | 634
GPCR 3 | 408
Transcription Factor 1 | 1,400
Transporter 1 | 473

GO Function

potassium channel regulator ac... 39 | 39
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily E member 2 KCNE2 Tbio Ion Channel -2.00780 91.4 120
Potassium voltage-gated channel subfamily E member 1 KCNE1 Tbio Ion Channel -2.67495 441.7 193
A-kinase anchor protein 9 AKAP9 Tbio Enzyme -2.22554 169.7 142
E3 ubiquitin-protein ligase NEDD4-like NEDD4L Tbio Enzyme -2.52486 353.9 144
Amphoterin-induced protein 1 AMIGO1 Tbio Non-IDG -1.74542 52.4 221
Dipeptidyl aminopeptidase-like protein 6 DPP6 Tbio Enzyme -2.06587 114.8 131
D(2) dopamine receptor DRD2 Tclin GPCR -3.28700 1882.2 264
Small ubiquitin-related modifier 1 SUMO1 Tbio Non-IDG -2.72599 482.7 786
Voltage-gated potassium channel subunit beta-3 KCNAB3 Tbio Ion Channel -0.71610 5.21 122
Serine/threonine-protein kinase Sgk2 SGK2 Tbio Kinase -0.80672 4.28 223