Development Level

Tbio 8 | 11,651

IMPC Phenotype

abnormal heart morphology 1 | 162
abnormal seminal vesicle morph... 1 | 114
decreased lymphocyte cell numb... 1 | 83
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hydrometra 1 | 53
increased erythrocyte cell num... 1 | 39
increased monocyte cell number 1 | 63
male infertility 1 | 123
preweaning lethality, complete... 1 | 979
small superior vagus ganglion 1 | 74

Disease

Carcinoma 8 | 11,493
osteosarcoma 6 | 7,950
ovarian cancer 5 | 8,520
Rheumatoid arthritis 4 | 1,191
malignant mesothelioma 4 | 3,232
medulloblastoma, large-cell 4 | 6,241
Sleeping sickness 3 | 37
ependymoma 3 | 4,679
glioblastoma 3 | 5,792
juvenile dermatomyositis 3 | 1,187
lung cancer 3 | 4,740
Astrocytoma, Pilocytic 2 | 3,081
Breast cancer 2 | 3,578
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
group 3 medulloblastoma 2 | 4,104
primitive neuroectodermal tumor 2 | 3,035
psoriasis 2 | 6,694
sarcoidosis 2 | 370
subependymal giant cell astrocytoma 2 | 2,287
Acute cystitis 1 | 35
Antisocial personality disorder 1 | 9
Attention deficit hyperactivity disorder 1 | 278
Autosomal recessive predisposition 1 | 1,442
Babinski Reflex 1 | 100
Cancer 1 | 2,499
Chagas disease 1 | 39
Chromosome 2p16.1-p15 deletion syndrome 1 | 8
Decreased tendon reflex 1 | 122
Delayed speech and language development 1 | 112
Dysarthria 1 | 192
Dyskeratosis congenita 1 | 24
Gaucher disease type 1 1 | 180
Hereditary spherocytosis type 2 1 | 18
Hodgkin's lymphoma 1 | 15
Kidney cancer 1 | 2,613
Language Delay 1 | 112
Male infertility 1 | 206
Melanoma 1 | 711
Multiple myeloma 1 | 1,332
Neurodegenerative disease 1 | 414
Nystagmus 1 | 317
Optic Atrophy 1 | 242
Pancreatitis 1 | 123
Paraparesis, Spastic 1 | 16
Perlman syndrome 1 | 9
Pick disease 1 | 1,894
Pyelonephritis 1 | 13
SPASTIC ATAXIA 4, AUTOSOMAL RECESSIVE 1 | 1
Slow progression 1 | 89
Spastic Ataxia 1 | 18
Speech Delay 1 | 112
Speech impairment 1 | 112
Type 1 diabetes mellitus 10 1 | 2
Waldenstrons macroglobulinemia 1 | 765
Xeroderma pigmentosum variant type 1 | 4
acute myeloid leukemia 1 | 783
aldosterone-producing adenoma 1 | 665
astrocytic glioma 1 | 2,597
atypical teratoid / rhabdoid tumor 1 | 5,112
atypical teratoid/rhabdoid tumor 1 | 357
chronic rhinosinusitis 1 | 512
cystic fibrosis and chronic rhinosinusitis 1 | 214
dermatomyositis 1 | 966
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 1 | 3,291
lung adenocarcinoma 1 | 2,716
medulloblastoma 1 | 720
non primary Sjogren syndrome sicca 1 | 891
non-small cell lung cancer 1 | 2,890
oligodendroglioma 1 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,962
pediatric high grade glioma 1 | 1,064
primary Sjogren syndrome 1 | 735
progressive supranuclear palsy 1 | 676
sonic hedgehog group medulloblastoma 1 | 467
spina bifida 1 | 1,074
tuberculosis and treatment for 6 months 1 | 409

Tissue

Endocrine System 8 | 18,159
Blood and immune system 7 | 16,909
Cardiovascular System 7 | 15,192
Digestive Tract 7 | 17,369
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Male tissues 7 | 17,142
Nervous System 7 | 16,725
Respiratory system 7 | 16,393
Skin and soft tissues 7 | 17,230
Urinary Tract 7 | 16,678

Target Family

Enzyme 8 | 4,145

GO Function

polynucleotide adenylyltransfe... 8 | 8
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Poly(A) polymerase beta PAPOLB Tbio Enzyme -1.66566 44.9 59
Poly(A) polymerase gamma PAPOLG Tbio Enzyme -2.00403 100.4 97
Poly(A) polymerase alpha PAPOLA Tbio Enzyme -0.76388 5.75 90
Speckle targeted PIP5K1A-regulated poly(A) polymerase TUT1 Tbio Enzyme -1.66339 47.9 64
Poly(A) RNA polymerase, mitochondrial MTPAP Tbio Enzyme -1.36829 24.0 68
Non-canonical poly(A) RNA polymerase PAPD5 PAPD5 Tbio Enzyme -0.76848 4.57 124
Poly(A) RNA polymerase GLD2 PAPD4 Tbio Enzyme -1.55374 35.4 81
Non-canonical poly(A) RNA polymerase PAPD7 PAPD7 Tbio Enzyme -2.31303 208.7 120