Development Level

Tbio 8 | 11,651

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal clavicle morphology 1 | 6
abnormal embryo size 1 | 220
abnormal rib morphology 1 | 10
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased prepulse inhibition 1 | 82
embryonic lethality prior to o... 1 | 239
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 7 | 11,493
ovarian cancer 7 | 8,520
medulloblastoma, large-cell 5 | 6,241
osteosarcoma 5 | 7,950
Breast cancer 4 | 3,578
Adult onset 3 | 82
Schizophrenia 3 | 1,160
acute quadriplegic myopathy 3 | 1,158
atypical teratoid / rhabdoid tumor 3 | 5,112
dermatomyositis 3 | 966
glioblastoma 3 | 5,792
group 3 medulloblastoma 3 | 4,104
lung cancer 3 | 4,740
subependymal giant cell astrocytoma 3 | 2,287
Amyotrophic lateral sclerosis 2 | 451
Bipolar Disorder 2 | 666
Cerebellar Dysmetria 2 | 56
Dysarthria 2 | 192
Dysdiadochokinesis 2 | 25
Epilepsy 2 | 792
Intellectual disability 2 | 1,016
Kidney cancer 2 | 2,613
Multiple myeloma 2 | 1,332
Muscle hypotonia 2 | 571
Neurodegenerative disease 2 | 414
Pick disease 2 | 1,894
Sphincter disturbances 2 | 16
Waldenstrons macroglobulinemia 2 | 765
adult high grade glioma 2 | 3,801
astrocytic glioma 2 | 2,597
atypical teratoid/rhabdoid tumor 2 | 357
cystic fibrosis 2 | 1,696
ependymoma 2 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
juvenile dermatomyositis 2 | 1,187
malignant mesothelioma 2 | 3,232
non-small cell lung cancer 2 | 2,890
pancreatic cancer 2 | 2,398
pediatric high grade glioma 2 | 1,064
primitive neuroectodermal tumor 2 | 3,035
progressive supranuclear palsy 2 | 676
psoriasis 2 | 6,694
Acquired flat foot 1 | 72
Action Tremor 1 | 22
Amenorrhea 1 | 58
Ataxia, Appendicular 1 | 25
Atypical autism 1 | 26
Chromosome 4q21 deletion syndrome 1 | 6
Congenital Abnormalities 1 | 11
Congenital Abnormality 1 | 11
Decreased distal vibration sense 1 | 4
Depressive Symptoms 1 | 28
Dilated fourth ventricle 1 | 4
Dysesthesia 1 | 6
Dysmetric saccades 1 | 9
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 54 1 | 1
Elevated gonadotropins 1 | 15
Erectile dysfunction 1 | 32
Explosive speech 1 | 9
Flatfoot 1 | 73
Fragile 10 Mental Retardation Syndrome 1 | 2
Gonadal Dysgenesis 1 | 28
Gynecomastia 1 | 64
High pitched voice 1 | 23
Impaired horizontal smooth pursuit 1 | 6
Impulse control disorder 1 | 4
Joint laxity 1 | 54
Macroorchidism 1 | 7
Mild Mental Retardation 1 | 70
Mitral Valve Prolapse Syndrome 1 | 39
Mixed anxiety and depressive disorder 1 | 12
Mood instability 1 | 2
Mucopolysaccharidosis II 1 | 5
Myalgia 1 | 54
Narrow face 1 | 54
Neurodegenerative Diseases 1 | 38
Nystagmus, End-Position 1 | 12
Obesity, Abdominal 1 | 24
Obsessive compulsive behavior 1 | 25
Obsessive-compulsive trait 1 | 4
Olivopontocerebellar Atrophies 1 | 6
Ovarian Failure, Premature 1 | 9
Ovarian dysfunction 1 | 18
Paranasal Sinus Diseases 1 | 34
Periventricular neuronal heterotopia 1 | 6
Poor eye contact 1 | 12
Premature Menopause 1 | 31
Progressive cerebellar ataxia 1 | 13
Rimmed vacuoles on biopsy 1 | 15
Scanning speech 1 | 9
Shoulder girdle weakness 1 | 10
Shoulder weakness 1 | 10
Sinusitis 1 | 65
Slowed saccades 1 | 12
Small hand 1 | 36
Spinocerebellar tract degeneration 1 | 4
Static Tremor 1 | 21
Terminal tremor 1 | 20
Thin face 1 | 54
clinical depression 1 | 6

Tissue

Blood and immune system 8 | 16,909
Cardiovascular System 8 | 15,192
Digestive Tract 8 | 17,369
Endocrine System 8 | 18,159
Female tissues 8 | 17,400
Liver and Pancreas 8 | 16,750
Male tissues 8 | 17,142
Nervous System 8 | 16,725
Respiratory system 8 | 16,393
Skin and soft tissues 8 | 17,230
Urinary Tract 8 | 16,678

Target Family

Non-IDG 6 | 12,091
Enzyme 1 | 4,145
Epigenetic 1 | 242

GO Function

poly(G) binding 8 | 8
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Heterogeneous nuclear ribonucleoprotein D-like HNRNPDL Tbio Non-IDG -1.04203 11.1 104
Synaptic functional regulator FMR1 FMR1 Tbio Epigenetic -3.38241 2443.7 484
DAZ-associated protein 1 DAZAP1 Tbio Non-IDG -1.36520 25.2 143
Heterogeneous nuclear ribonucleoprotein U HNRNPU Tbio Non-IDG -2.33813 207.8 169
Microspherule protein 1 MCRS1 Tbio Non-IDG -1.40659 32.1 99
Polyribonucleotide nucleotidyltransferase 1, mitochondrial PNPT1 Tbio Enzyme -2.39326 239.5 218
Protein PAT1 homolog 1 PATL1 Tbio Non-IDG -0.81143 7.84 65
Ataxin-1 ATXN1 Tbio Non-IDG -2.29370 203.4 610