Development Level

Tbio 796 | 10,625
Tdark 219 | 7,003
Tchem 83 | 1,890
Tclin 9 | 602

Collection

Eligible Kinase Proteins 4 | 134

IMPC Term

preweaning lethality, complete... 63 | 633
preweaning lethality, incomple... 19 | 260
abnormal behavior 14 | 226
embryonic lethality prior to o... 12 | 148
embryonic lethality prior to t... 12 | 187
decreased lean body mass 11 | 195
decreased bone mineral density 9 | 126
abnormal embryo size 8 | 112
decreased body weight 8 | 174
decreased bone mineral content 8 | 157
hyperactivity 8 | 108
increased fasted circulating g... 8 | 68
increased grip strength 8 | 83
abnormal retina morphology 7 | 100
decreased grip strength 7 | 123
abnormal bone structure 6 | 131
decreased body length 6 | 108
decreased circulating glucose ... 6 | 121
abnormal retinal pigmentation 5 | 61
decreased circulating choleste... 5 | 85
increased circulating HDL chol... 5 | 63
increased mean corpuscular vol... 5 | 91
increased or absent threshold ... 5 | 128
abnormal bone mineralization 4 | 55
abnormal coat/hair pigmentatio... 4 | 54
abnormal lens morphology 4 | 73
decreased circulating HDL chol... 4 | 77
increased circulating alkaline... 4 | 119
pallor 4 | 13
shortened RR interval 4 | 19
abnormal rib morphology 3 | 28
abnormal sleep behavior 3 | 63
decreased CD4-positive, CD25-p... 3 | 24
decreased caudal vertebrae num... 3 | 49
decreased circulating chloride... 3 | 32
decreased fasted circulating g... 3 | 49
decreased heart weight 3 | 44
decreased lymphocyte cell numb... 3 | 9
decreased neutrophil cell numb... 3 | 37
decreased total body fat amoun... 3 | 186
enlarged heart 3 | 111
hypoactivity 3 | 89
impaired glucose tolerance 3 | 52
increased NK cell number 3 | 19
increased bone mineral content 3 | 92
increased circulating choleste... 3 | 53
increased circulating creatini... 3 | 29
increased circulating phosphat... 3 | 24
increased circulating sodium l... 3 | 71
increased heart rate 3 | 17
increased sacral vertebrae num... 3 | 62
increased startle reflex 3 | 38
increased total body fat amoun... 3 | 57
prenatal lethality prior to he... 3 | 64
thrombocytosis 3 | 23
abnormal behavioral response t... 2 | 52
abnormal joint morphology 2 | 14
abnormal limb bud morphology 2 | 15
abnormal placenta size 2 | 10
abnormal snout morphology 2 | 18
abnormal spleen morphology 2 | 36
abnormal thoracic vertebrae mo... 2 | 16
cardiovascular system phenotyp... 2 | 35
cataract 2 | 26
decreased CD8-positive, alpha-... 2 | 26
decreased KLRG1+ CD8 alpha bet... 2 | 8
decreased KLRG1-positive NK ce... 2 | 9
decreased NK T cell number 2 | 28
decreased NK cell number 2 | 16
decreased circulating LDL chol... 2 | 37
decreased circulating alanine ... 2 | 53
decreased circulating amylase ... 2 | 24
decreased circulating free fat... 2 | 39
decreased circulating fructosa... 2 | 31
decreased circulating serum al... 2 | 79
decreased circulating sodium l... 2 | 18
decreased circulating thyroxin... 2 | 5
decreased circulating total pr... 2 | 41
decreased circulating triglyce... 2 | 83
decreased leukocyte cell numbe... 2 | 54
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular vol... 2 | 50
decreased rib number 2 | 59
decreased threshold for audito... 2 | 32
decreased total retina thickne... 2 | 20
hydrops fetalis 2 | 22
increased KLRG1-positive NK ce... 2 | 9
increased circulating chloride... 2 | 43
increased circulating free fat... 2 | 17
increased effector memory CD4-... 2 | 15
increased effector memory CD8-... 2 | 14
increased exploration in new e... 2 | 56
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular hem... 2 | 93
pale yolk sac 2 | 12
polydactyly 2 | 22
short tibia 2 | 82
shortened ST segment 2 | 9
abnormal neural tube closure 1 | 37
female infertility 1 | 34

Disease

ovarian cancer 728 | 8,484
osteosarcoma 549 | 7,933
medulloblastoma, large-cell 404 | 6,234
lung cancer 398 | 4,466
psoriasis 385 | 6,685
glioblastoma 335 | 5,572
Multiple myeloma 262 | 1,327
atypical teratoid / rhabdoid tumor 252 | 4,369
group 3 medulloblastoma 216 | 2,254
oligodendroglioma 201 | 2,849
Breast cancer 200 | 3,094
ependymoma 200 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 198 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 185 | 2,988
acute quadriplegic myopathy 180 | 1,157
malignant mesothelioma 173 | 3,162
primitive neuroectodermal tumor 173 | 3,031
Waldenstrons macroglobulinemia 165 | 765
astrocytoma 164 | 1,493
intraductal papillary-mucinous adenoma (IPMA) 164 | 2,956
lung adenocarcinoma 161 | 2,713
invasive ductal carcinoma 159 | 2,950
pediatric high grade glioma 158 | 2,712
Cancer 151 | 2,346
diabetes mellitus 147 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 147 | 1,795
Pick disease 146 | 1,893
subependymal giant cell astrocytoma 143 | 2,287
non-small cell lung cancer 142 | 2,798
astrocytic glioma 138 | 2,241
dermatomyositis 133 | 933
Carcinoma 131 | 2,147
pancreatic cancer 130 | 2,300
group 4 medulloblastoma 114 | 1,875
juvenile dermatomyositis 112 | 1,189
pilocytic astrocytoma 110 | 3,086
colon cancer 108 | 1,475
sonic hedgehog group medulloblastoma 94 | 1,482
acute myeloid leukemia 92 | 780
adult high grade glioma 91 | 2,148
breast carcinoma 87 | 1,614
primary pancreatic ductal adenocarcinoma 80 | 1,271
lung carcinoma 78 | 2,844
progressive supranuclear palsy 78 | 674
Rheumatoid Arthritis 76 | 1,160
tuberculosis and treatment for 6 months 74 | 686
medulloblastoma 69 | 1,524
pituitary cancer 65 | 1,972
ulcerative colitis 65 | 2,087
atypical teratoid/rhabdoid tumor 64 | 1,095
non primary Sjogren syndrome sicca 63 | 840
posterior fossa group A ependymoma 61 | 1,511
Amyotrophic Lateral Sclerosis 60 | 431
cystic fibrosis 60 | 1,665
ductal carcinoma in situ 60 | 1,745
nasopharyngeal carcinoma 51 | 1,056
adrenocortical carcinoma 49 | 1,427
spina bifida 47 | 1,064
hepatocellular carcinoma 46 | 532
tuberculosis 46 | 1,557
Intellectual disability 43 | 573
Mammary Neoplasms 41 | 410
Duchenne muscular dystrophy 39 | 602
gastric carcinoma 39 | 832
autosomal dominant Emery-Dreifuss muscular dystrophy 38 | 499
pancreatic carcinoma 38 | 567
aldosterone-producing adenoma 37 | 664
Alzheimer's disease 36 | 644
posterior fossa group B ependymoma 36 | 1,530
cutaneous lupus erythematosus 35 | 1,056
esophageal adenocarcinoma 35 | 737
interstitial cystitis 35 | 2,299
Down syndrome 33 | 548
Stomach Neoplasms 33 | 282
active Crohn's disease 33 | 918
Neurodegenerative disease 32 | 383
hereditary spastic paraplegia 32 | 313
primary Sjogren syndrome 31 | 789
Polycystic Ovary Syndrome 30 | 332
IGA Glomerulonephritis 29 | 454
gastric cancer 29 | 430
inflammatory breast cancer 28 | 404
Multiple Sclerosis 27 | 498
Gaucher disease type 1 26 | 171
Atopic dermatitis 25 | 944
Disease Progression 25 | 125
Prostatic Neoplasms 25 | 471
mucosa-associated lymphoid tissue lymphoma 25 | 480
Schizophrenia 23 | 501
interstitial lung disease 23 | 291
HIV Infections 22 | 100
Diamond-Blackfan anemia 21 | 28
Animal Mammary Neoplasms 20 | 136
Becker muscular dystrophy 20 | 187
Obesity 20 | 616
active ulcerative colitis 20 | 477
Mammary Neoplasms, Experimental 19 | 150
Parkinson's disease 19 | 364
fibroadenoma 18 | 557
non-small cell lung carcinoma 17 | 413

Tissue

Blood and immune system 1,101 | 17,995
Digestive Tract 1,100 | 18,473
Liver and Pancreas 1,100 | 18,136
Male tissues 1,100 | 17,969
Cardiovascular System 1,099 | 17,958
Female tissues 1,099 | 18,647
Nervous System 1,099 | 18,561
Endocrine System 1,097 | 18,512
Urinary Tract 1,097 | 18,444
Respiratory system 1,092 | 17,484
Skin and soft tissues 1,083 | 18,115

Target Family

Non-IDG 822 | 11,971
Enzyme 219 | 4,146
Transcription Factor 22 | 1,400
Epigenetic 20 | 242
Kinase 19 | 634
Transporter 5 | 473

GO Function

poly(A) RNA binding 1,107 | 1,107
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
HEAT repeat-containing protein 6 HEATR6 Tdark Non-IDG -1.48236 11.6 38
Nuclear cap-binding protein subunit 3 NCBP3 Tbio Non-IDG -1.68208 49.3 22
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Kinesin-like protein KIF1C KIF1C Tbio Non-IDG -1.21884 20.0 95
mRNA decay activator protein ZFP36 ZFP36 Tbio Non-IDG -2.38153 220.3 0
Methyl-CpG-binding protein 2 MECP2 Tchem Transcription Factor -3.22710 1827.6 567
Malate dehydrogenase, mitochondrial MDH2 Tchem Enzyme -2.21960 180.2 229
Desmoplakin DSP Tbio Non-IDG -2.90088 786.5 167