Development Level

Tbio 20 | 11,445
Tchem 9 | 1,598
Tclin 5 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal behavior 3 | 298
preweaning lethality, incomple... 3 | 499
decreased bone mineral density 2 | 126
decreased circulating calcium ... 2 | 36
decreased lean body mass 2 | 135
enlarged heart 2 | 210
small testis 2 | 58
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal maxilla morphology 1 | 17
abnormal optic disc morphology 1 | 10
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
absent startle reflex 1 | 24
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased circulating LDL chol... 1 | 38
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
enlarged spleen 1 | 41
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased blood urea nitrogen ... 1 | 48
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased heart rate 1 | 23
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
irregularly shaped pupil 1 | 7
prenatal lethality 1 | 28
scaly skin 1 | 4
shortened RR interval 1 | 17
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 27 | 11,493
ovarian cancer 23 | 8,520
medulloblastoma, large-cell 18 | 6,241
osteosarcoma 17 | 7,950
Cancer 15 | 2,499
psoriasis 14 | 6,694
Breast cancer 12 | 3,578
atypical teratoid / rhabdoid tumor 12 | 5,112
glioblastoma 11 | 5,792
adult high grade glioma 10 | 3,801
lung cancer 10 | 4,740
Intellectual disability 9 | 1,016
ependymoma 9 | 4,679
group 4 medulloblastoma 9 | 1,855
oligodendroglioma 9 | 2,850
Rheumatoid arthritis 8 | 1,191
diabetes mellitus 8 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
pancreatic cancer 8 | 2,398
Kidney cancer 7 | 2,613
Pick disease 7 | 1,894
breast carcinoma 7 | 1,638
juvenile dermatomyositis 7 | 1,187
malignant mesothelioma 7 | 3,232
Dull intelligence 6 | 645
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Poor school performance 6 | 645
group 3 medulloblastoma 6 | 4,104
interstitial cystitis 6 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
invasive ductal carcinoma 6 | 2,951
lung adenocarcinoma 6 | 2,716
lung carcinoma 6 | 2,843
subependymal giant cell astrocytoma 6 | 2,287
tuberculosis 6 | 2,010
Astrocytoma, Pilocytic 5 | 3,081
Broad flat nasal bridge 5 | 236
Epilepsy 5 | 792
Liver Cirrhosis, Experimental 5 | 769
Multiple myeloma 5 | 1,332
Nasal bridge wide 5 | 236
astrocytic glioma 5 | 2,597
colon cancer 5 | 1,478
cystic fibrosis 5 | 1,696
dermatomyositis 5 | 966
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
non-small cell lung cancer 5 | 2,890
primitive neuroectodermal tumor 5 | 3,035
Alzheimer's disease 4 | 658
Anteverted nostril 4 | 191
Autosomal recessive predisposition 4 | 1,442
Carcinoma, Hepatocellular 4 | 228
Cognitive delay 4 | 608
Congenital Epicanthus 4 | 177
Global developmental delay 4 | 608
Kidney disease 4 | 430
Liver carcinoma 4 | 240
Mental and motor retardation 4 | 608
Muscle hypotonia 4 | 571
Obesity 4 | 678
Orbital separation excessive 4 | 244
Schizophrenia 4 | 1,160
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Anemia 3 | 365
Autistic Disorder 3 | 364
Bladder Neoplasm 3 | 112
Brain Ischemia 3 | 110
Cardiovascular Diseases 3 | 59
Cerebral atrophy 3 | 178
Depressive disorder 3 | 409
Dysarthria 3 | 192
Frontal bossing 3 | 157
Glaucoma 3 | 239
Growth delay 3 | 114
Growth failure 3 | 114
Growth retardation 3 | 115
High forehead 3 | 102
Low set ears 3 | 181
Neurodegenerative disease 3 | 414
Parkinson's disease 3 | 392
Poor growth 3 | 114
Seizures 3 | 596
Short neck 3 | 140
Short nose 3 | 132
Small nose 3 | 132
Strabismus 3 | 270
Urinary Bladder Neoplasms 3 | 114
Vascular disease 3 | 319
Very poor growth 3 | 114
acute quadriplegic myopathy 3 | 1,158
adrenocortical carcinoma 3 | 1,428
esophageal adenocarcinoma 3 | 737
medulloblastoma 3 | 720
primary pancreatic ductal adenocarcinoma 3 | 1,109
spina bifida 3 | 1,074
tuberculosis and treatment for 6 months 3 | 409
ulcerative colitis 3 | 1,819

Tissue

Endocrine System 36 | 18,159
Female tissues 36 | 17,400
Male tissues 36 | 17,142
Digestive Tract 35 | 17,369
Liver and Pancreas 35 | 16,750
Skin and soft tissues 35 | 17,230
Urinary Tract 35 | 16,678
Blood and immune system 34 | 16,909
Nervous System 34 | 16,725
Respiratory system 34 | 16,393
Cardiovascular System 32 | 15,192

Target Family

Non-IDG 17 | 12,091
Enzyme 8 | 4,145
Kinase 5 | 634
Epigenetic 2 | 242
Ion Channel 2 | 344
Transcription Factor 2 | 1,400

GO Function

phosphoprotein binding 36 | 36
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable E3 ubiquitin-protein ligase MID2 MID2 Tbio Enzyme -2.49198 303.4 152
Unconventional prefoldin RPB5 interactor 1 URI1 Tbio Enzyme -2.15409 134.8 150
Polycystin-2 PKD2 Tchem Ion Channel -2.63806 461.3 231
Thyroid hormone receptor-associated protein 3 THRAP3 Tbio Non-IDG -0.87769 8.81 136
PHD finger protein 6 PHF6 Tbio Epigenetic -1.79561 64.2 134
Transducin beta-like protein 2 TBL2 Tbio Non-IDG -1.00878 10.8 139
Low-density lipoprotein receptor-related protein 11 LRP11 Tdark Non-IDG -0.62553 4.15 56
TOX high mobility group box family member 3 TOX3 Tbio Transcription Factor -1.64481 43.3 156
Arrestin-C ARR3 Tbio Non-IDG -1.99324 86.3 161
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150