Development Level

Tbio 54 | 11,651
Tchem 16 | 1,388
Tdark 5 | 6,593
Tclin 3 | 612

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased startle reflex 3 | 75
abnormal behavior 2 | 298
decreased circulating insulin ... 2 | 76
decreased circulating serum al... 2 | 82
increased circulating bilirubi... 2 | 16
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal eye anterior chamber ... 1 | 9
abnormal iris morphology 1 | 13
abnormal lens morphology 1 | 81
abnormal nail morphology 1 | 8
abnormal retinal inner nuclear... 1 | 8
abnormal tooth morphology 1 | 24
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
corneal opacity 1 | 32
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased heart rate variabili... 1 | 13
decreased lactate dehydrogenas... 1 | 16
decreased large unstained cell... 1 | 11
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
fused cornea and lens 1 | 5
hyperactivity 1 | 148
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 36
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
increased total retina thickne... 1 | 4
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
trunk curl 1 | 16

Disease

Carcinoma 54 | 11,493
medulloblastoma, large-cell 42 | 6,241
osteosarcoma 42 | 7,950
adult high grade glioma 40 | 3,801
glioblastoma 37 | 5,792
ovarian cancer 36 | 8,520
psoriasis 35 | 6,694
atypical teratoid / rhabdoid tumor 32 | 5,112
lung cancer 29 | 4,740
Astrocytoma, Pilocytic 28 | 3,081
ependymoma 28 | 4,679
subependymal giant cell astrocytoma 23 | 2,287
group 3 medulloblastoma 22 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
invasive ductal carcinoma 21 | 2,951
lung carcinoma 20 | 2,843
pancreatic cancer 20 | 2,398
primitive neuroectodermal tumor 20 | 3,035
Cancer 19 | 2,499
diabetes mellitus 19 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
oligodendroglioma 19 | 2,850
Atherosclerosis 17 | 291
Kidney cancer 17 | 2,613
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,962
Breast cancer 16 | 3,578
astrocytic glioma 16 | 2,597
lung adenocarcinoma 16 | 2,716
malignant mesothelioma 16 | 3,232
Coronary artery disease 15 | 268
Kidney disease 15 | 430
non-small cell lung cancer 15 | 2,890
tuberculosis 15 | 2,010
ductal carcinoma in situ 14 | 1,745
interstitial cystitis 14 | 2,312
astrocytoma 13 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
Autosomal recessive predisposition 12 | 1,442
Schizophrenia 12 | 1,160
pituitary cancer 12 | 1,972
Lipid metabolism disorder 11 | 114
Obesity 11 | 678
active Crohn's disease 11 | 922
active ulcerative colitis 11 | 764
colon cancer 11 | 1,478
juvenile dermatomyositis 11 | 1,187
acute quadriplegic myopathy 10 | 1,158
cystic fibrosis 10 | 1,696
Pick disease 9 | 1,894
breast carcinoma 9 | 1,638
ulcerative colitis 9 | 1,819
Cerebrovascular disease 8 | 238
Hypertension 8 | 396
Liver Cirrhosis, Experimental 8 | 769
cutaneous lupus erythematosus 8 | 1,057
spina bifida 8 | 1,074
Duchenne muscular dystrophy 7 | 601
Hypercholesterolemia, Familial 7 | 23
Intellectual disability 7 | 1,016
adrenocortical carcinoma 7 | 1,428
esophageal adenocarcinoma 7 | 737
group 4 medulloblastoma 7 | 1,855
nasopharyngeal carcinoma 7 | 1,058
Alzheimer's disease 6 | 658
Amyotrophic lateral sclerosis 6 | 451
Atopic dermatitis 6 | 952
Bipolar Disorder 6 | 666
Down syndrome 6 | 499
Heart disease 6 | 306
Hypercholesterolemia 6 | 44
Hyperlipoproteinemia Type II 6 | 12
Liver cancer 6 | 604
Seizures 6 | 596
Vascular disease 6 | 319
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
dermatomyositis 6 | 966
non primary Sjogren syndrome sicca 6 | 891
primary pancreatic ductal adenocarcinoma 6 | 1,109
Anemia 5 | 365
Autistic Disorder 5 | 364
Cardiovascular Diseases 5 | 59
Cardiovascular system disease 5 | 246
Cerebellar Ataxia 5 | 304
Cognitive delay 5 | 608
Depressive disorder 5 | 409
Epilepsy 5 | 792
Global developmental delay 5 | 608
Liver disease 5 | 237
Lung Neoplasms 5 | 232
Mental and motor retardation 5 | 608
Nerve Degeneration 5 | 121
Neurodegenerative disease 5 | 414
Osteoporosis 5 | 363
Polycystic ovary syndrome 5 | 360
Rheumatoid arthritis 5 | 1,191
Splenomegaly 5 | 190
aldosterone-producing adenoma 5 | 665
pancreatic carcinoma 5 | 562
acute myeloid leukemia 4 | 783
gastric carcinoma 4 | 807

Tissue

Endocrine System 78 | 18,159
Female tissues 78 | 17,400
Skin and soft tissues 78 | 17,230
Digestive Tract 77 | 17,369
Blood and immune system 76 | 16,909
Liver and Pancreas 76 | 16,750
Male tissues 76 | 17,142
Respiratory system 75 | 16,393
Urinary Tract 75 | 16,678
Nervous System 73 | 16,725
Cardiovascular System 67 | 15,192

Target Family

Non-IDG 50 | 12,091
Enzyme 18 | 4,145
Kinase 4 | 634
GPCR 2 | 408
Nuclear Receptor 2 | 48
Transporter 2 | 473

GO Function

phospholipid binding 78 | 78
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
E3 ubiquitin-protein ligase SMURF1 SMURF1 Tbio Enzyme -1.95365 89.3 331
Signal-transducing adaptor protein 1 STAP1 Tbio Non-IDG -0.38628 3.43 177
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide DAPP1 Tbio Non-IDG -1.14626 21.0 307
Amphiphysin AMPH Tbio Non-IDG -2.66933 440.3 354
Beta-2-glycoprotein 1 APOH Tbio Non-IDG -3.18007 1422.8 342
Protein kinase C iota type PRKCI Tchem Kinase -1.71694 51.2 148
Triggering receptor expressed on myeloid cells 2 TREM2 Tbio Non-IDG -2.42594 269.9 370
Protein kinase C and casein kinase substrate in neurons protein 1 PACSIN1 Tbio Enzyme -1.69638 47.7 226
Vesicle-associated membrane protein 2 VAMP2 Tbio Non-IDG -2.53335 323.7 203