Development Level

Tbio 3 | 11,445
Tchem 3 | 1,598

IMPC Phenotype

decreased circulating glucose ... 2 | 126
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
decreased blood urea nitrogen ... 1 | 51
decreased circulating choleste... 1 | 93
decreased circulating phosphat... 1 | 27
decreased mean corpuscular hem... 1 | 50
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
enlarged heart 1 | 210
enlarged kidney 1 | 14
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased red blood cell distr... 1 | 34
preweaning lethality, complete... 1 | 979
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

Carcinoma 5 | 11,493
osteosarcoma 4 | 7,950
ovarian cancer 4 | 8,520
Cardiomegaly 3 | 116
ependymoma 3 | 4,679
lung cancer 3 | 4,740
oligodendroglioma 3 | 2,850
psoriasis 3 | 6,694
Alzheimer's disease 2 | 658
Astrocytoma, Pilocytic 2 | 3,081
Breast cancer 2 | 3,578
Cancer 2 | 2,499
Liver Cirrhosis, Experimental 2 | 769
adult high grade glioma 2 | 3,801
glioblastoma 2 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung carcinoma 2 | 2,843
malignant mesothelioma 2 | 3,232
medulloblastoma, large-cell 2 | 6,241
non primary Sjogren syndrome sicca 2 | 891
non-small cell lung cancer 2 | 2,890
pituitary cancer 2 | 1,972
subependymal giant cell astrocytoma 2 | 2,287
ulcerative colitis 2 | 1,819
Acute kidney injury 1 | 70
Adrenoleukodystrophy 1 | 29
Adverse reaction to drug 1 | 61
Age related macular degeneration 1 | 72
Alzheimer Disease 1 | 83
Anemia 1 | 365
Anemia, Hemolytic 1 | 55
Bilirubin metabolic disorder 1 | 41
Blood Coagulation Disorders 1 | 42
Brain disease 1 | 96
Breast Neoplasms 1 | 445
COPD 1 | 118
Carotid Artery Diseases 1 | 11
Cerebral Hemorrhage 1 | 42
Chemical and Drug Induced Liver Injury 1 | 195
Chronic Obstructive Airway Disease 1 | 37
Colitis 1 | 54
Congestive heart failure 1 | 113
Conjunctivitis 1 | 53
Coronary artery disease 1 | 268
Diabetes Mellitus, Experimental 1 | 108
Diabetes Mellitus, Non-Insulin-Dependent 1 | 145
Diabetes Mellitus, Type 2 1 | 142
Diabetic Angiopathies 1 | 16
Drug-Related Side Effects and Adverse Reactions 1 | 62
Fibrosis 1 | 44
Gastroparesis 1 | 22
Growth Disorders 1 | 35
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
Heart disease 1 | 306
Heart failure 1 | 162
Hematuria 1 | 36
Hepatomegaly 1 | 285
Hepatorenal syndrome 1 | 6
Hyperglycemia 1 | 137
Hyperinsulinism 1 | 133
Hyperplasia 1 | 27
Hypertension 1 | 396
Inclusion conjunctivitis 1 | 8
Infarction, Middle Cerebral Artery 1 | 33
Inflammation 1 | 120
Insulin Resistance 1 | 72
Ischemia 1 | 28
Kidney disease 1 | 430
Liver disease 1 | 237
Liver diseases 1 | 87
Liver neoplasms 1 | 130
Lung Neoplasms 1 | 232
Lung disease 1 | 142
Malaria 1 | 160
Mammary Neoplasms 1 | 425
Mammary Neoplasms, Experimental 1 | 154
Neonatal Jaundice 1 | 30
Neoplasm Invasiveness 1 | 161
Neurodegenerative Disorders 1 | 79
Parkinson Disease 1 | 64
Parkinson's disease 1 | 392
Pneumonia 1 | 174
Poor growth 1 | 114
Pre-Eclampsia 1 | 68
Proteinuria 1 | 144
Pulmonary Disease, Chronic Obstructive 1 | 31
Pulmonary Fibrosis 1 | 106
Pulmonary emphysema 1 | 48
Reperfusion Injury 1 | 86
Retinal Diseases 1 | 55
Status Epilepticus 1 | 98
Stomach Neoplasms 1 | 300
Toxic encephalopathy 1 | 141
Very poor growth 1 | 114
Wounds and Injuries 1 | 18
active Crohn's disease 1 | 922
cystic fibrosis and chronic rhinosinusitis 1 | 214
tuberculosis 1 | 2,010

Tissue

Blood and immune system 6 | 16,909
Cardiovascular System 6 | 15,192
Digestive Tract 6 | 17,369
Endocrine System 6 | 18,159
Female tissues 6 | 17,400
Liver and Pancreas 6 | 16,750
Male tissues 6 | 17,142
Nervous System 6 | 16,725
Respiratory system 6 | 16,393
Skin and soft tissues 6 | 17,230
Urinary Tract 6 | 16,678

Target Family

Enzyme 6 | 4,145

GO Function

phospholipase D activity 6 | 6
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phospholipase D3 PLD3 Tbio Enzyme -1.77419 62.1 99
Phospholipase D4 PLD4 Tbio Enzyme -0.92277 9.56 136
Phospholipase D2 PLD2 Tchem Enzyme -2.47197 312.2 172
Phosphatidylinositol-glycan-specific phospholipase D GPLD1 Tbio Enzyme -2.08209 126.8 222
Phospholipase D1 PLD1 Tchem Enzyme -1.51188 30.9 203
Heme oxygenase 1 HMOX1 Tchem Enzyme -3.75004 6181.3 706