Development Level

Tbio 7 | 11,445
Tchem 3 | 1,598
Tclin 1 | 613

IMPC Phenotype

increased lean body mass 2 | 172
abnormal bone mineralization 1 | 38
abnormal digit morphology 1 | 10
abnormal gait 1 | 69
abnormal gallbladder morpholog... 1 | 1
abnormal locomotor behavior 1 | 24
abnormal vocalization 1 | 21
decreased IgG3 level 1 | 1
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mature B cell number 1 | 7
decreased total body fat amoun... 1 | 207
enlarged gallbladder 1 | 2
hydrometra 1 | 53
hypoactivity 1 | 132
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased erythrocyte cell num... 1 | 39
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74

Disease

Carcinoma 8 | 11,493
ependymoma 6 | 4,679
lung cancer 6 | 4,740
glioblastoma 5 | 5,792
lung carcinoma 5 | 2,843
malignant mesothelioma 5 | 3,232
osteosarcoma 5 | 7,950
ovarian cancer 5 | 8,520
psoriasis 5 | 6,694
Astrocytoma, Pilocytic 4 | 3,081
Cancer 4 | 2,499
Kidney cancer 4 | 2,613
adult high grade glioma 4 | 3,801
atypical teratoid / rhabdoid tumor 4 | 5,112
colon cancer 4 | 1,478
lung adenocarcinoma 4 | 2,716
medulloblastoma, large-cell 4 | 6,241
subependymal giant cell astrocytoma 4 | 2,287
Autosomal recessive predisposition 3 | 1,442
Breast cancer 3 | 3,578
Liver cancer 3 | 604
Schizophrenia 3 | 1,160
astrocytic glioma 3 | 2,597
group 3 medulloblastoma 3 | 4,104
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
primitive neuroectodermal tumor 3 | 3,035
Bipolar Disorder 2 | 666
Epilepsy 2 | 792
Melanoma 2 | 711
Osteoporosis 2 | 363
Pain 2 | 103
Tracheal stenosis 2 | 23
acute quadriplegic myopathy 2 | 1,158
cystic fibrosis and chronic rhinosinusitis 2 | 214
invasive ductal carcinoma 2 | 2,951
non-small cell lung cancer 2 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
ulcerative colitis 2 | 1,819
AUTOINFLAMMATION, ANTIBODY DEFICIENCY, AND IMMUNE DYSREGULATION, PLCG2-ASSOCIATED 1 | 1
Acute coronary syndrome 1 | 39
Acute exacerbation of asthma 1 | 14
Allergic rhinitis (disorder) 1 | 5
Angle class 2 malocclusion 1 | 57
Angle class 3 malocclusion 1 | 57
Ankylosis 1 | 28
Asthma management 1 | 19
Autosomal recessive congenital ichthyosis 4B 1 | 13
Bradycardia 1 | 36
Bronchiolitis 1 | 18
COPD Associated with Chronic Bronchitis 1 | 11
Catalepsy 1 | 15
Cellulitis 1 | 20
Cherubism 1 | 13
Chronic kidney disease stage 5 1 | 31
Cluster Headache Prevention 1 | 6
Cluster headache syndrome 1 | 8
Cryopyrin-Associated Periodic Syndromes 1 | 4
Decreased IgM 1 | 11
Dengue shock syndrome 1 | 6
Dentin dysplasia 1 | 19
Diffuse mesangial sclerosis (disorder) 1 | 7
Disorder of lung 1 | 7
Drug Hypersensitivity 1 | 34
Dysmenorrhea 1 | 21
Edema 1 | 81
FAMILIAL COLD AUTOINFLAMMATORY SYNDROME 3 1 | 1
Focal segmental glomerulosclerosis 1 | 10
Genetic Predisposition to Disease 1 | 27
Hashimoto Disease 1 | 4
Headache disorder 1 | 19
Hemangiosarcoma 1 | 18
Hypoplastic superior helix 1 | 4
Hypotension 1 | 82
Immune dysregulation 1 | 5
Infarction, Middle Cerebral Artery 1 | 33
Influenza-like symptoms 1 | 16
Ischemia 1 | 28
Ischemic Attack, Transient 1 | 10
Malocclusion 1 | 57
Multiple Endocrine Neoplasia Type 1 1 | 29
Myocardial Perfusion Imaging Adjunct 1 | 25
Nasal discharge 1 | 24
Neoplasms 1 | 63
Paroxysmal supraventricular tachycardia 1 | 12
Pneumonia, Interstitial 1 | 5
Retinal ischemia 1 | 7
SPINOCEREBELLAR ATAXIA 17 1 | 9
Seizures, Focal 1 | 14
Sinus headache 1 | 16
Skin Diseases, Bacterial 1 | 7
Tension-type headache 1 | 10
Townes-Brocks syndrome 1 | 15
Transient Ischemic Attack 1 | 10
Treacher Collins syndrome 1 | 27
Uveal melanoma 1 | 20
Vascular headache 1 | 7
esophageal cancer 1 | 22
nasal allergy 1 | 2

Tissue

Blood and immune system 11 | 16,909
Cardiovascular System 11 | 15,192
Digestive Tract 11 | 17,369
Endocrine System 11 | 18,159
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Male tissues 11 | 17,142
Nervous System 11 | 16,725
Respiratory system 11 | 16,393
Skin and soft tissues 11 | 17,230
Urinary Tract 11 | 16,678

Target Family

Enzyme 10 | 4,145
GPCR 1 | 408

GO Function

phospholipase C activity 11 | 11
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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