Development Level

Tbio 52 | 11,651
Tchem 5 | 1,388
Tdark 3 | 6,593
Tclin 1 | 612

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to t... 3 | 278
abnormal embryo size 2 | 220
abnormal lens morphology 2 | 81
embryonic lethality prior to o... 2 | 239
increased monocyte cell number 2 | 63
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
abnormal allantois morphology 1 | 8
abnormal blood vessel morpholo... 1 | 5
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal cornea morphology 1 | 31
abnormal embryo turning 1 | 31
abnormal forebrain development 1 | 20
abnormal heart looping 1 | 5
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal left-right axis patte... 1 | 2
abnormal limb bud morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal optic disc morphology 1 | 10
abnormal optic vesicle formati... 1 | 4
abnormal otic vesicle morpholo... 1 | 3
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal somite shape 1 | 5
abnormal tail bud morphology 1 | 8
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
anophthalmia 1 | 33
cataract 1 | 92
corneal opacity 1 | 32
decreased circulating alkaline... 1 | 46
decreased circulating chloride... 1 | 30
decreased circulating insulin ... 1 | 76
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased total body fat amoun... 1 | 207
dilated heart left ventricle 1 | 11
embryonic growth retardation 1 | 106
fused cornea and lens 1 | 5
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
increased cardiac stroke volum... 1 | 1
increased circulating amylase ... 1 | 25
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased erythrocyte cell num... 1 | 39
increased neutrophil cell numb... 1 | 46
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
small superior vagus ganglion 1 | 74

Disease

Carcinoma 45 | 11,493
ovarian cancer 34 | 8,520
osteosarcoma 30 | 7,950
psoriasis 28 | 6,694
glioblastoma 24 | 5,792
medulloblastoma, large-cell 23 | 6,241
ependymoma 21 | 4,679
group 3 medulloblastoma 19 | 4,104
atypical teratoid / rhabdoid tumor 17 | 5,112
subependymal giant cell astrocytoma 17 | 2,287
Astrocytoma, Pilocytic 16 | 3,081
adult high grade glioma 16 | 3,801
lung cancer 16 | 4,740
lung carcinoma 16 | 2,843
Breast cancer 15 | 3,578
primitive neuroectodermal tumor 14 | 3,035
interstitial cystitis 13 | 2,312
Kidney cancer 12 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
malignant mesothelioma 12 | 3,232
pancreatic cancer 12 | 2,398
astrocytic glioma 11 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
non-small cell lung cancer 10 | 2,890
oligodendroglioma 10 | 2,850
tuberculosis 10 | 2,010
ulcerative colitis 10 | 1,819
Autosomal recessive predisposition 9 | 1,442
Pick disease 9 | 1,894
acute quadriplegic myopathy 9 | 1,158
astrocytoma 9 | 1,146
lung adenocarcinoma 9 | 2,716
Cancer 8 | 2,499
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
pituitary cancer 8 | 1,972
invasive ductal carcinoma 7 | 2,951
primary pancreatic ductal adenocarcinoma 7 | 1,109
Epilepsy 6 | 792
cystic fibrosis 6 | 1,696
juvenile dermatomyositis 6 | 1,187
Alzheimer's disease 5 | 658
Duchenne muscular dystrophy 5 | 601
Multiple myeloma 5 | 1,332
Rheumatoid arthritis 5 | 1,191
adrenocortical carcinoma 5 | 1,428
ductal carcinoma in situ 5 | 1,745
nasopharyngeal carcinoma 5 | 1,058
pediatric high grade glioma 5 | 1,064
Bipolar Disorder 4 | 666
Liver cancer 4 | 604
acute myeloid leukemia 4 | 783
breast carcinoma 4 | 1,638
colon cancer 4 | 1,478
diabetes mellitus 4 | 1,728
sonic hedgehog group medulloblastoma 4 | 467
spina bifida 4 | 1,074
Atherosclerosis 3 | 291
Atopic dermatitis 3 | 952
Autistic Disorder 3 | 364
Cardiomyopathy 3 | 116
Down syndrome 3 | 499
Dull intelligence 3 | 645
Dysarthria 3 | 192
Hepatomegaly 3 | 285
Hypertension 3 | 396
Hypertensive disease 3 | 292
Hypertrophic Cardiomyopathy 3 | 117
Intellectual disability 3 | 1,016
Low intelligence 3 | 645
Melanoma 3 | 711
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Neurodegenerative disease 3 | 414
Obesity 3 | 678
Pain 3 | 103
Parkinson's disease 3 | 392
Poor school performance 3 | 645
Seizures 3 | 596
Type 2 diabetes mellitus 3 | 272
Weight Gain 3 | 100
active Crohn's disease 3 | 922
active ulcerative colitis 3 | 764
atypical teratoid/rhabdoid tumor 3 | 357
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
cutaneous lupus erythematosus 3 | 1,057
dermatomyositis 3 | 966
fibroadenoma 3 | 559
non primary Sjogren syndrome sicca 3 | 891
Acquired scoliosis 2 | 281
Chronic obstructive pulmonary disease 2 | 184
Curvature of spine 2 | 282
Depressive disorder 2 | 409
Failure to gain weight 2 | 365
Pediatric failure to thrive 2 | 365
Waldenstrons macroglobulinemia 2 | 765
chronic lymphosyte leukemia 2 | 204
chronic rhinosinusitis 2 | 512
pancreatic carcinoma 2 | 562
progressive supranuclear palsy 2 | 676

Tissue

Endocrine System 61 | 18,159
Male tissues 59 | 17,142
Nervous System 59 | 16,725
Skin and soft tissues 59 | 17,230
Digestive Tract 58 | 17,369
Female tissues 58 | 17,400
Liver and Pancreas 57 | 16,750
Urinary Tract 57 | 16,678
Blood and immune system 55 | 16,909
Respiratory system 55 | 16,393
Cardiovascular System 50 | 15,192

Target Family

Non-IDG 47 | 12,091
Enzyme 4 | 4,145
Ion Channel 3 | 344
Epigenetic 2 | 242
Transcription Factor 2 | 1,400
GPCR 1 | 408
Kinase 1 | 634
Transporter 1 | 473

GO Function

phosphatidylinositol-4,5-bisph... 61 | 61
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
Exocyst complex component 1 EXOC1 Tbio Non-IDG -1.85438 74.2 51
Twinfilin-1 TWF1 Tbio Non-IDG -1.08655 12.4 211
V(D)J recombination-activating protein 2 RAG2 Tbio Epigenetic -2.94111 784.2 194
Phosphatidylinositol-binding clathrin assembly protein PICALM Tbio Non-IDG -1.92862 84.7 130
Huntingtin-interacting protein 1-related protein HIP1R Tbio Non-IDG -1.52916 38.6 195
Alpha-actinin-2 ACTN2 Tbio Non-IDG -1.89804 72.9 245
Sorting nexin-21 SNX21 Tdark Non-IDG 0.09 1.15 73
Twinfilin-2 TWF2 Tbio Non-IDG -1.24879 17.8 162
Profilin-2 PFN2 Tbio Non-IDG -1.95013 88.9 212