Development Level

Tbio 45 | 10,625
Tchem 5 | 1,890
Tdark 4 | 7,003
Tclin 1 | 602

Collection

Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 6 | 633
embryonic lethality prior to t... 3 | 187
abnormal embryo size 2 | 112
decreased body weight 2 | 174
decreased lean body mass 2 | 195
embryonic lethality prior to o... 2 | 148
increased total body fat amoun... 2 | 57
abnormal allantois morphology 1 | 3
abnormal chorioallantoic fusio... 1 | 2
abnormal embryo turning 1 | 15
abnormal limb bud morphology 1 | 15
abnormal neural tube closure 1 | 37
abnormal neural tube morpholog... 1 | 8
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 100
abnormal skin condition 1 | 6
abnormal tail bud morphology 1 | 6
decreased bone mineral content 1 | 157
decreased circulating LDL chol... 1 | 37
decreased circulating alkaline... 1 | 41
decreased circulating chloride... 1 | 32
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased fasted circulating g... 1 | 49
decreased prepulse inhibition 1 | 52
decreased spleen weight 1 | 13
decreased total body fat amoun... 1 | 186
decreased total retina thickne... 1 | 20
dilated heart left ventricle 1 | 10
embryonic growth retardation 1 | 28
fused cornea and lens 1 | 4
impaired glucose tolerance 1 | 52
increased cardiac stroke volum... 1 | 1
increased circulating alkaline... 1 | 119
increased circulating amylase ... 1 | 13
increased circulating aspartat... 1 | 17
increased circulating calcium ... 1 | 32
increased circulating glucose ... 1 | 16
increased circulating phosphat... 1 | 24
increased erythrocyte cell num... 1 | 26
pale yolk sac 1 | 12
pallor 1 | 13
prenatal lethality prior to he... 1 | 64
preweaning lethality, incomple... 1 | 260

Disease

ovarian cancer 31 | 8,491
osteosarcoma 26 | 7,933
psoriasis 25 | 6,685
glioblastoma 20 | 5,572
medulloblastoma, large-cell 19 | 6,234
lung carcinoma 15 | 2,844
pilocytic astrocytoma 15 | 3,086
primitive neuroectodermal tumor 14 | 3,031
subependymal giant cell astrocytoma 14 | 2,287
atypical teratoid / rhabdoid tumor 13 | 4,369
Breast cancer 12 | 3,098
lung cancer 12 | 4,473
interstitial cystitis 11 | 2,299
pancreatic cancer 11 | 2,300
pediatric high grade glioma 11 | 2,712
adult high grade glioma 10 | 2,148
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
non-small cell lung cancer 10 | 2,798
ulcerative colitis 10 | 2,087
astrocytoma 9 | 1,493
ependymoma 9 | 2,514
group 3 medulloblastoma 9 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,289
malignant mesothelioma 9 | 3,163
Carcinoma 8 | 2,147
Pick disease 8 | 1,893
acute quadriplegic myopathy 8 | 1,157
astrocytic glioma 8 | 2,241
lung adenocarcinoma 8 | 2,714
oligodendroglioma 8 | 2,849
invasive ductal carcinoma 7 | 2,950
primary pancreatic ductal adenocarcinoma 7 | 1,271
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,795
pituitary cancer 6 | 1,972
sonic hedgehog group medulloblastoma 6 | 1,482
tuberculosis 6 | 1,563
Cancer 5 | 2,346
Rheumatoid Arthritis 5 | 1,170
cystic fibrosis 5 | 1,670
ductal carcinoma in situ 5 | 1,745
juvenile dermatomyositis 5 | 1,189
medulloblastoma 5 | 1,524
posterior fossa group B ependymoma 5 | 1,530
Alzheimer's disease 4 | 644
Duchenne muscular dystrophy 4 | 602
Multiple myeloma 4 | 1,327
Retinitis pigmentosa 4 | 156
adrenocortical carcinoma 4 | 1,427
atypical teratoid/rhabdoid tumor 4 | 1,095
posterior fossa group A ependymoma 4 | 1,511
Atherosclerosis 3 | 275
Atopic dermatitis 3 | 944
Hypertrophic Cardiomyopathy 3 | 56
Hypokalemia 3 | 40
Type 2 diabetes mellitus 3 | 192
Weight Gain 3 | 87
acute myeloid leukemia 3 | 785
breast carcinoma 3 | 1,614
colon cancer 3 | 1,475
cutaneous lupus erythematosus 3 | 1,056
diabetes mellitus 3 | 1,663
fibroadenoma 3 | 557
group 4 medulloblastoma 3 | 1,875
nasopharyngeal carcinoma 3 | 1,056
spina bifida 3 | 1,064
Autistic Disorder 2 | 320
Becker muscular dystrophy 2 | 187
Bipolar Disorder 2 | 266
Blindness 2 | 84
Cardiomyopathies 2 | 90
Cardiomyopathy 2 | 110
Cone dystrophy 2 | 59
Down syndrome 2 | 548
Epilepsy 2 | 346
Familial atrial fibrillation 2 | 16
Fundus dystrophy 2 | 77
Heart disease 2 | 279
Hypertension 2 | 293
Hypertensive disease 2 | 193
Leber congenital amaurosis 2 | 72
Liver Cirrhosis 2 | 101
Long QT syndrome 2 | 53
Metabolic acidosis 2 | 49
Multiple Sclerosis 2 | 498
Neurodegenerative disease 2 | 383
Night Blindness 2 | 39
Obesity 2 | 616
Osteoporosis 2 | 259
Parkinson's disease 2 | 364
active Crohn's disease 2 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
chronic lymphosyte leukemia 2 | 232
chronic rhinosinusitis 2 | 512
esophageal adenocarcinoma 2 | 737
gastric carcinoma 2 | 832
pancreatic carcinoma 2 | 567
primary Sjogren syndrome 2 | 788
sarcoidosis 2 | 368
tuberculosis and treatment for 3 months 2 | 327

Tissue

Blood and immune system 55 | 17,994
Endocrine System 55 | 18,511
Female tissues 55 | 18,646
Liver and Pancreas 55 | 18,135
Male tissues 55 | 17,968
Nervous System 55 | 18,560
Urinary Tract 55 | 18,443
Cardiovascular System 54 | 17,957
Digestive Tract 54 | 18,472
Respiratory system 53 | 17,483
Skin and soft tissues 53 | 18,114

Target Family

Non-IDG 43 | 11,969
Enzyme 3 | 4,146
Ion Channel 3 | 341
Epigenetic 2 | 242
Transcription Factor 2 | 1,400
Kinase 1 | 634
Transporter 1 | 473

GO Function

phosphatidylinositol-4,5-bisph... 55 | 55
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine-threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
SEC14 domain and spectrin repeat-containing protein 1 SESTD1 Tbio Non-IDG -0.65079 5.02 55
Twinfilin-1 TWF1 Tbio Non-IDG -1.07756 12.2 177
Synaptotagmin-7 SYT7 Tbio Non-IDG -1.72363 48.4 144
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.87621 876.7 339
Adseverin SCIN Tbio Non-IDG -1.89109 86.1 56
MTSS1-like protein MTSS1L Tdark Non-IDG -0.32543 1.95 16
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.49899 328.4 157
Low density lipoprotein receptor adapter protein 1 LDLRAP1 Tbio Non-IDG -2.41826 254.8 304
COMM domain-containing protein 1 COMMD1 Tbio Non-IDG -1.78848 64.7 141
Villin-1 VIL1 Tbio Non-IDG -2.18134 153.7 231