Development Level

Tbio 28 | 11,445
Tdark 5 | 6,588
Tchem 1 | 1,598

IMPC Phenotype

abnormal craniofacial morpholo... 2 | 33
abnormal retina morphology 2 | 71
decreased lean body mass 2 | 135
edema 2 | 59
enlarged heart 2 | 210
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal facial morphology 1 | 17
abnormal forebrain morphology 1 | 10
abnormal gait 1 | 69
abnormal head shape 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal hindbrain morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal limb morphology 1 | 13
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal tail morphology 1 | 25
anophthalmia 1 | 33
cleft palate 1 | 8
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased grip strength 1 | 116
decreased heart rate variabili... 1 | 13
decreased heart weight 1 | 27
decreased red blood cell distr... 1 | 41
decreased respiratory quotient 1 | 16
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
exencephaly 1 | 2
impaired glucose tolerance 1 | 75
increased caudal vertebrae num... 1 | 7
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
pallor 1 | 34
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
spina bifida 1 | 2
syndactyly 1 | 23
thrombocytopenia 1 | 56

Disease

Carcinoma 25 | 11,493
osteosarcoma 21 | 7,950
ovarian cancer 19 | 8,520
medulloblastoma, large-cell 15 | 6,241
glioblastoma 14 | 5,792
psoriasis 13 | 6,694
atypical teratoid / rhabdoid tumor 10 | 5,112
Kidney cancer 9 | 2,613
adult high grade glioma 8 | 3,801
Breast cancer 7 | 3,578
Pick disease 7 | 1,894
group 3 medulloblastoma 7 | 4,104
interstitial cystitis 7 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
invasive ductal carcinoma 7 | 2,951
Astrocytoma, Pilocytic 6 | 3,081
ependymoma 6 | 4,679
lung cancer 6 | 4,740
subependymal giant cell astrocytoma 6 | 2,287
Rheumatoid arthritis 5 | 1,191
adrenocortical carcinoma 5 | 1,428
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
malignant mesothelioma 5 | 3,232
non-small cell lung cancer 5 | 2,890
Intellectual disability 4 | 1,016
cystic fibrosis 4 | 1,696
oligodendroglioma 4 | 2,850
pituitary cancer 4 | 1,972
primitive neuroectodermal tumor 4 | 3,035
ulcerative colitis 4 | 1,819
Crohn's disease 3 | 321
Liver cancer 3 | 604
Neurodegeneration with brain iron accumulation 5 3 | 9
Neurodegenerative disease 3 | 414
Prostatic Neoplasms 3 | 495
active Crohn's disease 3 | 922
astrocytic glioma 3 | 2,597
astrocytoma 3 | 1,146
breast carcinoma 3 | 1,638
ductal carcinoma in situ 3 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
pancreatic cancer 3 | 2,398
primary pancreatic ductal adenocarcinoma 3 | 1,109
spina bifida 3 | 1,074
Abnormal ocular motility 2 | 19
Atopic dermatitis 2 | 952
Autosomal recessive predisposition 2 | 1,442
Bipolar Disorder 2 | 666
Cancer 2 | 2,499
Down syndrome 2 | 499
Dull intelligence 2 | 645
Fundus dystrophy 2 | 83
Glaucoma 2 | 239
Low intelligence 2 | 645
Macular degeneration 2 | 65
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Multiple myeloma 2 | 1,332
Obesity 2 | 678
Polycystic ovary syndrome 2 | 360
Poor school performance 2 | 645
Schizophrenia 2 | 1,160
Vici syndrome 2 | 14
X-linked dominant 2 | 57
acute myeloid leukemia 2 | 783
aldosterone-producing adenoma 2 | 665
cutaneous lupus erythematosus 2 | 1,057
gastric cancer 2 | 459
gastric carcinoma 2 | 807
lung adenocarcinoma 2 | 2,716
lung carcinoma 2 | 2,843
mucosa-associated lymphoid tissue lymphoma 2 | 484
pediatric high grade glioma 2 | 1,064
periodontitis 2 | 293
primary Sjogren syndrome 2 | 735
tuberculosis 2 | 2,010
Brachydactyly 1 | 156
COPD 1 | 118
Chorioretinal atrophy 1 | 11
Ciliopathy 1 | 71
Decreased visual acuity, progressive 1 | 36
Hearing Loss 1 | 17
Hyperopia 1 | 70
Learning disability 1 | 17
Lymphoid leukemia 1 | 160
Mood swings 1 | 77
Mucopolysaccharidosis III 1 | 7
Neuro-degenerative disease 1 | 43
Neurodegenerative Disorders 1 | 79
Otitis Media 1 | 52
Ovarian Neoplasms 1 | 102
Parkinsonian Disorders 1 | 56
Progressive visual loss 1 | 36
Recurrent sinus disease 1 | 22
Recurrent sinusitis 1 | 22
Retinoschisis 1 | 10
Tetralogy of Fallot 1 | 63
Weight Gain 1 | 100
inflammatory breast cancer 1 | 286
ovarian neoplasm 1 | 99

Tissue

Blood and immune system 34 | 16,909
Endocrine System 34 | 18,159
Nervous System 34 | 16,725
Respiratory system 34 | 16,393
Cardiovascular System 33 | 15,192
Digestive Tract 33 | 17,369
Female tissues 33 | 17,400
Liver and Pancreas 33 | 16,750
Male tissues 33 | 17,142
Skin and soft tissues 33 | 17,230
Urinary Tract 33 | 16,678

Target Family

Non-IDG 33 | 12,091
Enzyme 1 | 4,145

GO Function

phosphatidylinositol-3-phospha... 34 | 34
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sorting nexin-13 SNX13 Tbio Non-IDG -0.67169 5.24 65
Pleckstrin homology-like domain family A member 3 PHLDA3 Tbio Non-IDG -0.83900 8.89 101
Lateral signaling target protein 2 homolog ZFYVE28 Tbio Non-IDG 0.04 0.75 77
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Junctophilin-2 JPH2 Tbio Non-IDG -2.21890 163.0 229
WASH complex subunit 2C WASHC2C Tbio Non-IDG -0.83634 0.00000 45
Pleckstrin homology domain-containing family F member 1 PLEKHF1 Tbio Non-IDG -1.81298 66.0 108
SEC14 domain and spectrin repeat-containing protein 1 SESTD1 Tbio Non-IDG -0.75718 5.72 91
Retinoschisin RS1 Tbio Non-IDG -2.10828 131.3 39
SH3 and PX domain-containing protein 2B SH3PXD2B Tbio Non-IDG -1.72872 53.3 71